Les<i>leishmanioses</i>vues au travers du réseau international des Instituts Pasteur

Louzir, Hechmi; Karim, Abdul; Späth, Gérald F.; Laouini, Dhafer; Prina, Éric; Victoir, Kathleen; Bouratbine, A.

doi:10.1051/medsci/20132912020

Cited by 7 publications

(2 citation statements)

References 60 publications

(76 reference statements)

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“…In fact, this term includes a wide spectrum of vector-borne diseases with great epidemiological and clinical diversity. Even though exact statistical data are lacking (1,2), within the 350 million people that live in areas where leishmaniasis is endemic, approximately 12 million people get infected per year. There are three major clinical types: cutaneous (CL), mucocutaneous (MCL), and visceral leishmaniasis (VL; also known as kala-azar), which differ in their immunopathologies and degrees of morbidity and mortality (3).…”

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confidence: 99%

Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents

Baquedano

Alcolea

Toro

et al. 2016

Antimicrob Agents Chemother

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A series of new selenocyanates and diselenides bearing interesting bioactive scaffolds (quinoline, quinoxaline, acridine, chromene, furane, isosazole, etc.) was synthesized, and their in vitro leishmanicidal activities against Leishmania infantum amastigotes along with their cytotoxicities in human THP-1 cells were determined. Interestingly, most tested compounds were active in the low micromolar range and led us to identify four lead compounds (1h, 2d, 2e, and 2f) with 50% effective dose (ED 50 ) values ranging from 0.45 to 1.27 M and selectivity indexes of >25 for all of them, much higher than those observed for the reference drugs. These active derivatives were evaluated against infected macrophages, and in order to gain preliminary knowledge about their possible mechanism of action, the inhibition of trypanothione reductase (TryR) was measured. Among these novel structures, compounds 1h (3,5-dimethyl-4-isoxazolyl selenocyanate) and 2d [3,3=-(diselenodiyldimethanediyl)bis(2-bromothiophene)] exhibited good association between TryR inhibitory activity and antileishmanial potency, pointing to 1h, for its excellent theoretical ADME (absorption, distribution, metabolism, and excretion) properties, as the most promising lead molecule for leishmancidal drug design.

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confidence: 99%

Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents

Baquedano

Alcolea

Toro

et al. 2016

Antimicrob Agents Chemother

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“…Treatment of non-healing CL with IFN-gamma resulted in rapid and complete resolution of lesions [21]. However, the immunopathological and immunoprotective mechanisms occurring during CL are difficult to establish without longitudinal studies accounting for the genetic heterogeneity of human and parasite populations [22].…”

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confidence: 99%

Control of cutaneous leishmaniasis caused by Leishmania major in south‐eastern Morocco

Bennis

Brouwere

Ameur

et al. 2015

Tropical Med Int Health

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Abstractobjective The incidence of cutaneous leishmaniasis (CL) caused by Leishmania major has increased in Morocco over the last decade, prompting the Ministry of Health to take intersectoral response measures including vector and reservoir control. The aim of this article was to describe the CL outbreak response measures taken in the province of Errachidia, where the reservoir of L. major, a sand rat (Meriones shawi), was targeted using strychnine-poisoned wheat baits from 2010 to 2012.method We analysed routine surveillance data and other information using the data of the CL control programme.results We present data on the evolution and the extension of CL in this province as well as the epidemiological profile of the disease. Between 2004 and 2013, 7099 cases of CL were recorded in Errachidia Province, gradually affecting all districts. Our results demonstrate that more women were affected than men and that all age groups were represented.conclusion Errachidia Province was the epicentre of the recent CL outbreak in Morocco. A notable decline in incidence rates was observed after 2011. The outbreak control measures may have contributed to this decline, as well as climatic trends or progressing herd immunity.

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Pharmacophore modeling, docking and molecular dynamics to identify Leishmania major farnesyl pyrophosphate synthase inhibitors

et al. 2018

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Lesleishmaniosesvues au travers du réseau international des Instituts Pasteur

Cited by 7 publications

References 60 publications

Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents

Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents

Control of cutaneous leishmaniasis caused by Leishmania major in south‐eastern Morocco

Pharmacophore modeling, docking and molecular dynamics to identify Leishmania major farnesyl pyrophosphate synthase inhibitors

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