Les hypophysites : aspects cliniques et évolutifs

Fedala, N.S.; Chentli, F.; Meskine, D.; Haddam, A.E.M.

doi:10.1016/j.ando.2016.07.272

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have been able to compile seven cases over a period of 6 years, whereas Fedala et al . in Algeria reported a total of 15 cases over 16 years[ 10 ] and Imber et al . reported 21 cases over 17 years.…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation and management of hypophysitis: An observational study of case series

Karrou¹,

Benyakhlef²,

Alla³

et al. 2021

Surgical Neurology International

View full text Add to dashboard Cite

Background: Hypophysitis is described as a rare chronic inflammatory affection of the pituitary gland. However, to date, its pathogenesis has not been completely cleared up. Clinical features are polymorphic, including symptoms related to inflammatory compression and/or hypopituitarism. Laboratory tests determine hormone deficiencies orientating replacement therapy’s protocol. MRI of the hypothalamic-pituitary region is crucial in exhibiting major radiological signs such as pituitary homogeneous enlargement and gland stalk’s thickening. The etiological diagnosis is still challenging without affecting the management strategy. Corticosteroids have widely been used but a close follow-up without any treatment has also been approved. Case Description: In this report, seven patients with hypophysitis have been collected over a period of 6 years. The average age of our patients was 32.1 years ± 11.8 with a female predominance (71.4%). Panhypopituitarism was objective in 42.9% of cases, a combined deficiency of the hypothalamic-pituitary thyroid, adrenal and gonadal axes in 28.6% of cases. A central diabetes insipidus was noted in 42.9% of the patients. Idiopathic hypophysitis was the most common etiology. The use of long course corticosteroids was required in 28.6% when compressive signs were reported. Conclusion: Hypophysitis remains a rare disease with nonspecific clinical and radiological patterns. Autoimmune origin seems to be the most frequent etiology. No guidelines have been established for hypophysitis management and the evolution is still unpredictable.

show abstract

Section: Discussionmentioning

confidence: 99%