Les effets extra-osseux de la vitamine D : faits, questions et controverses

Background: Vitamin D deficiency may increase the risk of various autoimmune diseases. But few studies focused on its role in Behcet syndrome. Objectives:The aims of our study were to assess the vitamin D status of Behcet patients and to analyze the correlation of this status with the activity and the severity of the disease as well as the quality of life of patients. Patients and methods:The vitamin D status was assessed in 40 patients with Behcet syndrome (average age: 37.5 years, sex ratio: 1.85) in comparison with 40 healthy control subjects matched by age, sex and by season of assessment. A correlation study was realized between vit D levels and duration of disease progression, its activity, its severity as well as the quality of life of patients. Results:The average rate of vit D was 14.64 ng/ml (3-44.29 ng/ ml). 94.6% of them had hypovitaminose D. Vit D deficiency has been attested in 35.1% and insufficiency in 59.5% of the cases. There was no significant difference between rates of vit D in Behcet patients and those of healthy controls. There was also no significant association between vit D levels in Behcet patients and duration of disease progression, activity and severity as well as their quality of life. Conclusion:we made the evidence of hypovitaminose D in Behcet patients. Even if its role in the determination of Behcet syndrome is not obvious, this track remains to be explored.

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“…The average severity index was 4.7 (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). 81 % of patients had a score below of 6 and only 2.7% of them above 10.…”

Section: Resultsmentioning

confidence: 95%

“…In addition to its role in calcium and phosphorus metabolism, vit D has also an immunomodulatory function. It is, indeed, widely accepted that this hormone plays an active role in the regulation of both innate and acquired immune systems [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status of Behcet’s patients. Analysis of correlation with activity and severity of the disease as well as with the quality of life of patients

Kéchida¹,

Harzallah²,

Hellara³

et al. 2015

Int Arch Med

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“…(10) in 2002. In this study, hypovitaminosis D was defined by serum 25-hydroxyvitamin D concentrations under the limit of 38 nmol/L, which has been considered, since many years, insufficient to ensure optimal effect of vitamin D on health (11). A wide optimal range for vitamin D is reported, and differences of opinion exist as to the definition of vitamin deficiency.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D in healthy Tunisian population: Preliminary results

Bahlous¹,

Krir²,

Mrad³

et al. 2022

J Med Biochemistry

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Vitamin D deficiency is one of the most common medical conditions worldwide. In Tunisia, several studies evaluated Vitamin D status, but this was concerning specific populations (pregnant women, obese or diabetic patients and children with asthma). The only study that evaluated Vitamin D status in a healthy Tunisian population was conducted by Meddeb and al. in 2002. The update of data available, based on the currently recommended limits, is necessary. This study aimed to estimate the prevalence of hypovitaminosis D in a healthy Tunisian population, and correlate the values with potential risk factors. It was conducted on 209 Tunisian healthy subjects. Data collected included clinical characteristics and dietary intakes. We measured 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), glycemia, creatinine, calcium, phosphorus, proteins and alkaline phosphatase levels. Hypovitaminosis D was retained for 25(OH)D concentrations <30ng/ml. Vitamin D deficiency was defined by 25(OH)D concentrations <10 ng/ml. The prevalence of hypovitaminosis D and vitamin D deficiency were respectively 92.3% and 47.6%. The main factors that were significantly associated with low vitamin D levels in our multivariate analysis were veiling, living in rural areas and sunscreen use. However, sex, age, socioeconomic level, phototype, solar exposure score, smoking and bone mass index, were not statistically associated with hypovitaminosis D. The study of relationship between vitamin D status and serum PTH levels showed a significative and negative correlation (p< 0.005). Given the high prevalence of vitamin D, an adapted health policy is essential. A widespread vitamin D supplementation and food fortification seems to be necessary in Tunisia.

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