Les chordomes

George, Bernard; Bresson, D.; Bouazza, S.; Froelich, Sébastien; Mandonnet, Emmanuel; Hamdi, S.; Orabi, M.; Polivka, Marc; Cazorla, Arnault; Adle‐Biassette, Homa; Guichard, J.-P.; Duet, M.; Gayat, Étienne; Vallée, Fabrice; Canova, C.-H.; Riet, F.-G.; Bolle, Stéphanie; Calugaru, Valentin; Dendale, R.; Mazeron, Jean‐Jacques; Feuvret, L.; Boissier, Émilie; Vignot, Stéphane; Puget, Stéphanie; Sainte‐Rose, Christian; Beccaria, Kévin

doi:10.1016/j.neuchi.2014.02.003

Cited by 41 publications

(34 citation statements)

References 457 publications

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“…The radiological appearance of SBC is very heterogeneous and has been scarcely described and correlated with prognosis in the literature [59,60]. The degree of contrast enhancement in chordoma is not systematically described and is not considered in the modern clinical and radiological patient management as a prognostic factor in SBC [60,61].…”

Section: Discussionmentioning

confidence: 99%

Long and Very-Long-Chain Ceramides Correlate with A More Aggressive Behavior in Skull Base Chordoma Patients

Corte

Dei

Raggi

et al. 2019

IJMS

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Background: Skull base chordomas are rare tumors arising from notochord. Sphingolipids analysis is a promising approach in molecular oncology, and it has never been applied in chordomas. Our aim is to investigate chordoma behavior and the role of ceramides. Methods: Ceramides were extracted and evaluated by liquid chromatography and mass spectrometry in a cohort of patients with a skull base chordoma. Clinical data were also collected and correlated with ceramide levels. Linear regression and correlation analyses were conducted. Results: Analyzing the association between ceramides level and MIB-1, total ceramides and dihydroceramides showed a strong association (r = 0.7257 and r = 0.6733, respectively) with MIB-1 staining (p = 0.0033 and p = 0.0083, respectively). Among the single ceramide species, Cer C24:1 (r = 0.8814, p ≤ 0.0001), DHCer C24:1 (r = 0.8429, p = 0.0002) and DHCer C18:0 (r = 0.9426, p ≤ 0.0001) showed a significant correlation with MIB-1. Conclusion: Our lipid analysis showed ceramides to be promising tumoral biomarkers in skull base chordomas. Long- and very-long-chain ceramides, such as Cer C24:1 and DHCer C24:1, may be related to a prolonged tumor survival and aggressiveness, and the understanding of their effective biological role will hopefully shed light on the mechanisms of chordoma radio-resistance, tendency to recur, and use of agents targeting ceramide metabolism.

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Section: Discussionmentioning

confidence: 99%

Long and Very-Long-Chain Ceramides Correlate with A More Aggressive Behavior in Skull Base Chordoma Patients

Corte

Dei

Raggi

et al. 2019

IJMS

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“…Sacro-coccygeal chordoma is a rare malignant bone tumor derived from an attack of the notochord, described for the first time by Wirchow in 1857 [1]. In 1858, Muller specified its notochordal origin [2]. It represents 1 to 4% of bone tumors; sacro-coccygeal localization is one of the most frequent, especially between the 4th and 6th decades, whereas sphenooccipital localization is frequent in children and adolescents.…”

Section: Discussionmentioning

confidence: 99%

Reactive depression in a sacro coccygeal chordoma

Dialé¹,

Fall²,

Aida³

et al. 2019

IJPRR

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Research Article IJPRR (2019) 2:7 Reactive depression in a sacro coccygeal chordoma The association of depression and organic diseases is frequently described. Several authors have been interested in analyzing the links between the two entities. Depression is considered the dominant mode of reaction to somatic disorders. It is all the more frequent and marked that the disorder is life-threatening, painful, disabling. In this work, we report a reaction depression occurring in a patient with a sacro-coccygeal chordoma which is a relatively rare malignancy, with a reserved prognosis, revealed by common radiculalgia of appearance. This one required a care in Psychiatry parallel to the surgery. We emphasize the interest and the need for a multidisciplinary management framework.

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“…The more extensively the tumor is removed, the better the prognosis. Completeness of resection is considered the most important prognostic factor 11 , but there is the problem of preserving function which feasibility depends on the subsites affected by the tumor and the intrinsic morbidity of the surgical approach. The cranial nerves may be damaged both by the disease and by the surgical approach: cranial nerve VI, when the disease is in the petrous apex or crossed by the surgical corridor; the lower cranial nerves from IX to XII, when the tumor extends infero-laterally in the jugular foramen, lower clivus and condyle, or when surgery requires extensive drilling in the medial aspect of the jugular foramen.…”

Section: Advancements and Open Issuesmentioning

confidence: 99%

“…The goal of surgery should be the removal of all macroscopic tumor, since it is generally agreed that this is the most important factor influencing survival. Adjuvant radiation is the rule after surgery, even in cases where no macroscopic residual tumor is evident 511121415 .…”

Section: Advancements and Open Issuesmentioning

confidence: 99%

Surgery of the lateral skull base: a 50-year endeavour

Zanoletti¹,

Mazzoni²,

Martini³

et al. 2019

Acta Otorhinolaryngol Ital

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SUMMARY Disregarding the widely used division of skull base into anterior and lateral, since the skull base should be conceived as a single anatomic structure, it was to our convenience to group all those approaches that run from the antero-lateral, pure lateral and postero-lateral side of the skull base as “Surgery of the lateral skull base”. “50 years of endeavour” points to the great effort which has been made over the last decades, when more and more difficult surgeries were performed by reducing morbidity. The principle of lateral skull base surgery, “remove skull base bone to approach the base itself and the adjacent sites of the endo-esocranium”, was then combined with function preservation and with tailoring surgery to the pathology. The concept that histology dictates the extent of resection, balancing the intrinsic morbidity of each approach was the object of the first section of the present report. The main surgical approaches were described in the second section and were conceived not as a step-by-step description of technique, but as the highlighthening of the surgical principles. The third section was centered on open issues related to the tumor and its treatment. The topic of vestibular schwannoma was investigated with the current debate on observation, hearing preservation surgery, hearing rehabilitation, radiotherapy and the recent efforts to detect biological markers able to predict tumor growth. Jugular foramen paragangliomas were treated in the frame of radical or partial surgery, radiotherapy, partial “tailored” surgery and observation. Surgery on meningioma was debated from the point of view of the neurosurgeon and of the otologist. Endolymphatic sac tumors and malignant tumors of the external auditory canal were also treated, as well as chordomas, chondrosarcomas and petrous bone cholesteatomas. Finally, the fourth section focused on free-choice topics which were assigned to aknowledged experts. The aim of this work was attempting to report the state of the art of the lateral skull base surgery after 50 years of hard work and, above all, to raise questions on those issues which still need an answer, as to allow progress in knowledge through sharing of various experiences. At the end of the reading, if more doubts remain rather than certainties, the aim of this work will probably be achieved.

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Les chordomes

Cited by 41 publications

References 457 publications

Long and Very-Long-Chain Ceramides Correlate with A More Aggressive Behavior in Skull Base Chordoma Patients

Long and Very-Long-Chain Ceramides Correlate with A More Aggressive Behavior in Skull Base Chordoma Patients

Reactive depression in a sacro coccygeal chordoma

Surgery of the lateral skull base: a 50-year endeavour

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