Les cellules lymphoïdes innées

Cherrier, Marie

doi:10.1051/medsci/20143003016

Cited by 10 publications

(3 citation statements)

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“…Over the last decade, the activating receptor NKp46, renamed Natural Cytotoxicity Receptor 1 (NCR1) in the new nomenclature, had come to be considered as the prototypal marker to define NK cells in most species [35,54,55]. However, various recent studies on innate immune cells in mice and humans led to the discovery that NCR1+ cells not only include conventional NK cells (cNK) but also innate lymphoid cells (ILC) of groups 1 and 3 (including NK22/ILC22) [56]. In mouse and human, ILCs participate in the intestinal defence and homeostasis but, to date, these cells have not been characterized in ruminants and their presence in this species is therefore still speculative.…”

Section: Discussionmentioning

confidence: 99%

The early intestinal immune response in experimental neonatal ovine cryptosporidiosis is characterized by an increased frequency of perforin expressing NCR1+ NK cells and by NCR1− CD8+ cell recruitment

Olsen

Åkesson

Storset

et al. 2015

Vet Res

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Cryptosporidium parvum, a zoonotic protozoan parasite, causes important losses in neonatal ruminants. Innate immunity plays a key role in controlling the acute phase of this infection. The participation of NCR1+ Natural Killer (NK) cells in the early intestinal innate immune response to the parasite was investigated in neonatal lambs inoculated at birth. The observed increase in the lymphocyte infiltration was further studied by immunohistology and flow cytometry with focus on distribution, density, cellular phenotype related to cytotoxic function and activation status. The frequency of NCR1+ cells did not change with infection, while their absolute number slightly increased in the jejunum and the CD8+/NCR1- T cell density increased markedly. The frequency of perforin+ cells increased significantly with infection in the NCR1+ population (in both NCR1+/CD16+ and NCR1+/CD16- populations) but not in the NCR1-/CD8+ population. The proportion of NCR1+ cells co-expressing CD16+ also increased. The fraction of cells expressing IL2 receptor (CD25), higher in the NCR1+/CD8+ population than among the CD8+/NCR1- cells in jejunal Peyer’s patches, remained unchanged during infection. However, contrary to CD8+/NCR1- lymphocytes, the intensity of CD25 expressed by NCR1+ lymphocytes increased in infected lambs. Altogether, the data demonstrating that NK cells are highly activated and possess a high cytotoxic potential very early during infection, concomitant with an up-regulation of the interferon gamma gene in the gut segments, support the hypothesis that they are involved in the innate immune response against C. parvum. The early significant recruitment of CD8+/NCR1- T cells in the small intestine suggests that they could rapidly drive the establishment of the acquired immune response.Electronic supplementary materialThe online version of this article (doi:10.1186/s13567-014-0136-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

The early intestinal immune response in experimental neonatal ovine cryptosporidiosis is characterized by an increased frequency of perforin expressing NCR1+ NK cells and by NCR1− CD8+ cell recruitment

Olsen

Åkesson

Storset

et al. 2015

Vet Res

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“…Les cellules lymphoïdes innées (innate lymphoid cells, ILC) [41] (➜) représentent seulement 1 à 2 % des cellules hématopoïétiques dans l'intestin mais elles y jouent un rôle important lié à leur capacité à initier et orienter les réponses immunes intestinales [13]. Contrairement aux lymphocytes T et B, elles n'ont pas de récepteur de reconnaissance des antigènes et leur activation est induite par des cytokines produites par l'épithélium ou les cellules dendritiques en réponse aux modifications de l'environnement.…”

Section: Les Cellules Lymphoïdes Innéesunclassified

Microbiote intestinal et développement du système immunitaire

Gaboriau-Routhiau

Cerf‐Bensussan

2016

Med Sci (Paris)

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“…Néanmoins, elles se distinguent d'autres populations immunitaires par l'absence de réarrangements des récepteurs à l'antigène dépendant du gène RAG (recombination-activating genes), par l'absence de marqueurs phénotypiques de cellules myéloïdes et dendritiques, et par leur morphologie lymphoïde [4]. Les plus connues des ILC sont les cellules natural killer (NK) et les cellules inductrices de tissus lymphoïdes (LTi, lymphoid tissue inducers) [3]. Ces cellules immunitaires innées résident dans les régions barrières du corps des mammifères, la peau, les voies respiratoires et le tube intestinal [4].…”

Section: Les Cellules Lymphoïdes Innéesunclassified