Les cellules du muscle chantent en chœur une berceuse pour cellules souches

Microvascular Skeletal-Muscle Crosstalk in Health and Disease

“…Finally, ECs via induction of Notch signaling and the activation of the downstream factor DII4 maintain SC quiescence [32], which is also promoted by angiopoietin-1 produced by vascular mural cells/pericytes [33,34]. Accordingly, there is considerable interaction and cross-talk between SCs and ECs in promoting myo-angiogenesis, cross-talk essential for the regeneration of skeletal muscle and associated vasculature post trauma [2,[35][36][37][38] and most likely, but yet to be determined, in angio-myogenesis in the fetus (Table 1). In the embryo, pax3 + and pax3 + /7 + myogenic progenitor cells (MPC) proliferate and form primary myofibers which serve as scaffolding for the formation of muscle fibers, which occurs following continued proliferation of MPCs and expression of myogenic regulatory factors including MyoD, Myf5 and Mrf4.…”

“…Finally, ECs via induction of Notch signaling and the activation of the downstream factor DII4 maintain SC quiescence [ 32 ], which is also promoted by angiopoietin-1 produced by vascular mural cells/pericytes [ 33 , 34 ]. Accordingly, there is considerable interaction and cross-talk between SCs and ECs in promoting myo-angiogenesis, cross-talk essential for the regeneration of skeletal muscle and associated vasculature post trauma [ 2 , 35 , 36 , 37 , 38 ] and most likely, but yet to be determined, in angio-myogenesis in the fetus ( Table 1 ).…”

Développement d’un microenvironnement artificiel pour maintenir la quiescence et le potentiel thérapeutique des cellules souches du muscle squelettique

“…Définir de meilleures conditions de culture de ces cellules souches pourrait permettre leur persistance et leur expansion sans pour autant affecter leur efficacité thérapeutique. Entre autres tissus, le muscle squelettique possède des cellules souches présentant un très grand pouvoir régénératif qui se traduit par un fort potentiel de transplantation et de repopulation du tissu d'origine [3] (➜). Ces cellules souches se maintiennent à l'état quiescent sur de très longues périodes : des mois pour la souris et des années pour l'homme [4,5].…”