Les cellules dendritiques inflammatoires

Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases

“…pDCs are devoid of mannose receptors and express high levels of CD123. However, like LCs and DDs, pDCs also activate CD4 ϩ and CD8 ϩ antigen-specific T lymphocytes and secrete IL-12 during viral infections (Table 1) (13,71,79,80).…”

“…These cells express an Fc-like receptor that has a high affinity for immunoglobulin E (IgE) and is involved in allergen-specific inflammatory processes. Although these cellular activities have been described to occur in the epidermis, they are involved in inflammatory processes in both the epidermis and dermis (Table 1) (67,80).…”

State-of-the-art of regulatory dendritic cells in cancer

“…These DCs are generically termed regulatory DCs and include very diverse myeloid subsets of different origins and activities. Although the abundance and phenotype of regulatory DCs reported in different tumors varies, immunosuppressive attributes have been associated with DCs representing the major DC subsets in mice and humans: Plasmacytoid, conventional and inflammatory DCs (Bachem, et al, 2010; Haniffa, et al, 2012; Manh, Alexandre, Baranek, Crozat, & Dalod, 2013; Merad, Sathe, Helft, Miller, & Mortha, 2013; Segura & Amigorena, 2013, 2014; Segura, et al, 2013). …”

“…tDCs therefore include the short-lived leukocytes that typically arise from a hematopoietic lineage distinct from other leukocytes (Merad, et al, 2013; Schraml, et al, 2013), but also inflammatory cells derived from monocytes or DCs exhibiting markers differing from DCs generated during steady-state conditions, such as FcεRI and CCR7. Exhaustive studies by Amigorena and colleagues have characterized inflammatory DCs as human CD11c + CD115 + CD1c + CD1a + FcεRI + CD206 + CD172a + CD14 + CD11b + leukocytes and CD11c + MHC-II + CD11b + F4/80 + Ly6C + CD206 + CD115 + CD107b + FcεRI + CD64 + cells in mice (Segura & Amigorena, 2013, 2014). Although their precise ontogeny in inflammatory conditions remains unclear, inflammatory DCs can certainly arise from monocytes, and produce high levels of the pro-inflammatory cytokines TNF, IL-6, and IL-12 (O’Keeffe, et al, 2015).…”

Les cellules dendritiques humaines dans l’asthme et la rhinite allergique

“…Il faut également signaler la présence, au sein de la muqueuse respiratoire, d'un sous-type de cellules dendritiques exprimant le CD1a et la langerine, rappelant les cellules de Langerhans cutanées [12,13,55]. L'équivalent humain des CD inflammatoires de la souris a été mis en évidence pour la 1 re fois en 2013 [14,56], dans le liquide synovial de patients souffrant de polyarthrite rhumatoïde, ainsi que dans l'ascite de patientes atteintes d'un cancer ovarien. Ces cellules ont un génotype et un phénotype intermédiaires entre ceux de monocytes et de CD conventionnelles myéloïdes et ont la capacité d'induire une réponse Th17.…”