Les cancers de l’ovaire : incidence et mortalité en France

Trétarre, Brigitte; Remontet, Laurent; Ménegoz, F; Macé-Lesec'h, J; Grosclaude, Pascale; Buémi, Antoine; Guizard, A. V.; Velten, M; Arveux, Patrick; Peng, J; Jougla, Éric; Laffargue, F; Jp, Daurès

doi:10.1016/s0368-2315(05)82707-3

Cited by 21 publications

(5 citation statements)

References 7 publications

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“…Epithelial Ovarian carcinoma (EOC) is the sixth most common malignancy in woman and the leading cause of death from gynecological cancer [1,2]. One of the main differences between EOC and other neoplasm is burden of local extension.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model

et al. 2013

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BackgroundThe early peritoneal invasion of epithelial ovarian cancer (EOC) by tumoral aggregates presents in ascites is a major concern. The role of the microenvironment seems to be important in this process but the lack of adequate models to study cellular interactions between cancer cells and stromal cells does not allow to uncover the molecular pathways involved. Our goal was to study the interactions between ovarian cancer cells (OCC) and mesenchymal stem cells (MSC) using a 3D model.MethodsWe used millimetric pieces of amniochorionic membrane - referred to as amniotic membrane scaffold (AMS) - to create 3D peritoneal nodules mimicking EOC early invasion. We were able to measure the distribution and the depth of infiltration using confocal microsopy. We extracted MSC from the amniochorionic membrane using the markers CD34-, CD45-, CD73+, CD90+, CD105+ and CD29+ at the Fluorescence Activated Cell Sorting (FACS) analysis. We used transwell and wound healing tests to test OCC migration and invasion in vitro.ResultsHere we show that OCC tumors were located in regions rich in MSC (70%). The tumors infiltrated deeper within AMS in regions rich in MSC (p<0.001). In vitro tests revealed that higher IL6 secretion in a context of MSC-OCC co-culture could enhance migration and invasion of OCC. After IL6 receptor antagonism, OCC infiltration was significantly decreased, mostly in regions rich in MSCs, indicating that recruitment and tridimensional invasion of OCC was dependent of IL6 secretion.ConclusionsThe use of tridimensional models using AMS could be a useful tool to decipher early molecular events in ovarian cancer metastasis. Cytokine inhibitors interrupting the cross-talk between OCCs and MSCs such as IL6 should be investigated as a new therapeutic approach in ovarian cancer.

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Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model

et al. 2013

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“…The calling signs are insidious and do not appear that in case of tumors evolved . The suggestive symptoms reported have summer: bloating, increased abdominal volume, asthenia, urinary problems, pain pelvic or abdominal [5].…”

Section: Table Vi: Summary Of Cases Of Relapses In Elderly Patients (...mentioning

confidence: 99%

“…The particularity of ovarian cancer lies in its character silent responsible for a diagnostic delay and difficulty therapeutic especially in its shapes extents [ 1 ]. In order to improve the prognosis of patients by socket early care , screening methods _ _ systematic including a dosage of CA 125 and a ultrasound endovaginal have summer proposed but the results were disappointing [2][3][4][5] . The catch in charge remains difficult in the centers means equipped like ours .…”

Section: Introductionmentioning

confidence: 99%

Clinical Therapeutic and Prognostic Aspects of Ovarian Adenocarcinomas Followed by the Medical Oncology Department of Bejaia University Hospital

et al. 2023

IJFMR

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Ovarian cancer is relatively common but serious and has a poor prognosis. The aim of this study is to highlight the epidemiological, diagnostic, therapeutic and evolutionary aspects of this malignant pathology managed at the Bejaia university hospital center. This is a retrospective and descriptive study over a period of 3 years (2019 - 2022) carried out on 20 patients who developed ovarian cancer. The average age of the patients was 50 years old, 53.23% of whom were over 45 years old. The CA-125 blood test was positive in 18 out of 20 patients. The tumors were discovered on ultrasound in 87.10% of cases and at laparotomy in 12.90%. Total hysterectomy with bilateral adnexectomy was the most performed procedure (64.52%). The early postoperative course was simple. 15 patients underwent second look surgery (16.13%) for locoregional recurrences. Epithelial tumors were the most frequent histological type (93.55%), including 79% in the advanced stage ( IIIc -IV) and 21% in the early stage (Ia- Ib ). Adjuvant chemotherapy was administered in 80% of patients. With a median follow-up of 36 months, 2 patients were lost to follow-up. The evolution was favorable in 27.42% and in 25.81% deaths occurred late postoperatively. Ovarian cancer is not common but serious given the advanced stages and the high rate of late postoperative deaths which were largely observed in patients deprived of adequate neoadjuvant or adjuvant chemotherapy.

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“…This diagnostic delay makes treatment difficult and the prognosis poor with more than 152,000 deaths each year worldwide [8] [10]. Ovarian cancer represents the fourth leading cause of female cancer deaths after breast cancer, colon cancer and lung cancer [12]. Among gynecological cancers, it constitutes the leading cause of death [4] [13].…”

Section: Introductionmentioning

confidence: 99%

Ovarian Cancer: Clinical, Therapeutic and Prognostic Aspects at the University Hospital Center of Conakry in Guinea

Diallo,

Diallo

et al. 2023

OJOG

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Background: Ovarian cancer is the seventh most common cancer in women in the world and is the leading cause of death among gynecological cancers. Objective: The objective of this study was to describe the clinical, therapeutic and prognostic aspects of ovarian cancer in the both Gynecology-Obstetrics departments Donka and Ignace Deen of the Conakry University Hospital. Methods: This was a retrospective, descriptive study lasting 12 years from January 1, 2011 to December 31, 2022, covering the files of patients treated for ovarian cancer in the both Gynecology-Obstetrics departments Donka and Ignace Deen. The study focused on the epidemiological, clinical, histological and therapeutic aspects of the disease. Results: In total, 135 files of patients with ovarian cancer were collected out of the 3821 files of gynecological pathologies recorded in the two departments during the study period, either a frequency of 3.5%. Among gynecological and breast cancers, ovarian cancer represented 9.1%. The average age of the patients was 46.3± 17.8 years and the average parity was 4 ± 3. The revealing clinical signs were dominated by pelvic pain (92.6%) and increased abdominal volume (53.3%). The diagnosis of the disease was made mainly at stages III and IV (71.9%). The most common histological type was serous papillary adenocarcinoma (57.0%). Exclusive surgical treatment was performed in 8.1% of patients, surgery combined with chemotherapy in 63.0% of patients and exclusive chemotherapy in 11.1% of patients. After an average follow-up of 42 months, 29 patients out of the 96 operated on were alive (30.2%), 51 had died (53.1%) and 16 patients were lost to follow-up (16.7%). Conclusion: Ovarian cancer is the third most common

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Les cancers de l’ovaire : incidence et mortalité en France

Cited by 21 publications

References 7 publications

Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model

Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model

Clinical Therapeutic and Prognostic Aspects of Ovarian Adenocarcinomas Followed by the Medical Oncology Department of Bejaia University Hospital

Ovarian Cancer: Clinical, Therapeutic and Prognostic Aspects at the University Hospital Center of Conakry in Guinea

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