Les bases de pharmacologie fondamentale du système sérotoninergique : application à la réponse antidépressive

David, D. J.; Gardier, Alain M.

doi:10.1016/j.encep.2016.03.012

Cited by 41 publications

(23 citation statements)

References 54 publications

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“…5-HT released from serotoninergic neurons in the DRN throughout the brain modulates the acute stress response via its impact on a diverse group of serotonin receptors (for review, see [ 35 ]). Among the serotoninergic receptors, the 5-HT 1A receptor (5-HTR 1A ), located either on the presynaptic (autoreceptor) or postsynaptic (heteroreceptor) terminals of…”

Section: The Serotonergic Systemmentioning

confidence: 99%

Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population

Faye

McGowan

Denny

et al. 2018

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Background:Stress is a common reaction to an environmental adversity, but a dysregulation of the stress response can lead to psychiatric illnesses such as major depressive disorder (MDD), post-traumatic stress disorder (PTSD), and anxi-ety disorders. Yet, not all individuals exposed to stress will develop psychiatric disorders; those with enhanced stress resili-ence mechanisms have the ability to adapt successfully to stress without developing persistent psychopathology. Notably, the potential to enhance stress resilience in at-risk populations may prevent the onset of stress-induced psychiatric disorders. This novel idea has prompted a number of studies probing the mechanisms of stress resilience and how it can be manipulat-ed.Methods: Here, we review the neurobiological factors underlying stress resilience, with particular focus on the serotoninergic (5-HT), glutamatergic, and γ-Aminobutyric acid (GABA) systems, as well as the hy-pothalamic-pituitary axis (HPA) in rodents and in humans. Finally, we discuss stress resiliency in the context of aging, as the likelihood of mood disorders increases in older adults.Results: Interestingly, increased resiliency has been shown to slow aging and improved overall health and quality of life. Research in the neurobiology of stress resilience, particularly throughout the aging process, is a nascent, yet, burgeoning field.Conclusion: Overall, we consider the possible methods that may be used to induce resilient phenotypes, prophylactically in at-risk populations, such as in military personnel or in older MDD patients. Research in the mechanisms of stress resilience may not only elucidate novel targets for antidepressant treatments, but also provide novel insight about how to prevent these debilitating disorders from developing.

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Section: The Serotonergic Systemmentioning

confidence: 99%

Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population

Faye

McGowan

Denny

et al. 2018

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“…Furthermore, the connection between the platelet surface receptors and Von Willebrand factor (vWF) [ 23 ] on the endothelial collagen has put platelet and endothelium together, leading to the platelet adhesion. Meanwhile, the activated platelet's degranulation releases different kinds of factors including adenosine diphosphate (ADP), thromboxane A2 (TXA2) [ 24 ], and serotonin [ 25 , 26 ] ( Figure 2 ) that might have different impact on platelet including the platelet aggregation as well as vasoconstriction.…”

Section: Anticoagulant Mechanism Of Heparinsmentioning

confidence: 99%

Techniques for Detection of Clinical Used Heparins

Zhao

2021

International Journal of Analytical Chemistry

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Heparins and sulfated polysaccharides have been recognized as effective clinical anticoagulants for several decades. Heparins exhibit heterogeneity depending on the sources. Meanwhile, the adverse effect in the clinical uses and the adulteration of oversulfated chondroitin sulfate (OSCS) in heparins develop additional attention to analyze the purity of heparins. This review starts with the description of the classification, anticoagulant mechanism, clinical application of heparins and focuses on the existing methods of heparin analysis and detection including traditional detection methods, as well as new methods using fluorescence or gold nanomaterials as probes. The in-depth understanding of these techniques for the analysis of heparins will lay a foundation for the further development of novel methods for the detection of heparins.

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“…Thus far, the vast majority of marketed antidepressants act through the serotoninergic and norepinephrinergic systems, elevating synaptic levels of the corresponding neurotransmitters by blocking the monoamine transporters [ 12 , 13 , 14 , 15 ]. Many adverse effects associated with first-generation antidepressants (mainly tricyclic and monoamine oxidase inhibitors, –MAOi–) were partially overcome by the arrival of second-generation antidepressants, including selective serotonin reuptake inhibitors (SSRIs), norepinephrine reuptake inhibitors (NRIs), and dual antidepressants (SNRIs), with the latter being advantageous as they can treat a wide range of symptoms [ 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Docking, 3-D-Qsar, and Biological Assays of Novel Indole Derivatives Targeting Serotonin Transporter, Dopamine D2 Receptor, and Mao-A Enzyme: In the Pursuit for Potential Multitarget Directed Ligands

et al. 2020

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A series of 27 compounds of general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7(a–o) and (2-{4-[3-(1H-3-indolyl)-propyl]-1-piperazinyl}-acetylamine)-N-(2-morfolin-4-yl-ethyl)-fluorinated benzamides Series II: 13(a–l) were synthesized and evaluated as novel multitarget ligands towards dopamine D2 receptor, serotonin transporter (SERT), and monoamine oxidase-A (MAO-A) directed to the management of major depressive disorder (MDD). All the assayed compounds showed affinity for SERT in the nanomolar range, with five of them displaying Ki values from 5 to 10 nM. Compounds 7k, Ki = 5.63 ± 0.82 nM, and 13c, Ki = 6.85 ± 0.19 nM, showed the highest potencies. The affinities for D2 ranged from micro to nanomolar, while MAO-A inhibition was more discrete. Nevertheless, compounds 7m and 7n showed affinities for the D2 receptor in the nanomolar range (7n: Ki = 307 ± 6 nM and 7m: Ki = 593 ± 62 nM). Compound 7n was the only derivative displaying comparable affinities for SERT and D2 receptor (D2/SERT ratio = 3.6) and could be considered as a multitarget lead for further optimization. In addition, docking studies aimed to rationalize the molecular interactions and binding modes of the designed compounds in the most relevant protein targets were carried out. Furthermore, in order to obtain information on the structure–activity relationship of the synthesized series, a 3-D-QSAR CoMFA and CoMSIA study was conducted and validated internally and externally (q2 = 0.625, 0.523 for CoMFA and CoMSIA and r2ncv = 0.967, 0.959 for CoMFA and CoMSIA, respectively).

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Les bases de pharmacologie fondamentale du système sérotoninergique : application à la réponse antidépressive

Cited by 41 publications

References 54 publications

Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population

Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population

Techniques for Detection of Clinical Used Heparins

Synthesis, Docking, 3-D-Qsar, and Biological Assays of Novel Indole Derivatives Targeting Serotonin Transporter, Dopamine D2 Receptor, and Mao-A Enzyme: In the Pursuit for Potential Multitarget Directed Ligands

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