Les Associations Michobiennes Leurs Applications Thérapeutiques

Mycophenolic Acid: A One Hundred Year Odyssey from Antibiotic to Immunosuppressant

“…Therapeutic possibilities were considered and, to a limited extent, implemented. 16 Strangely, neither Fleming's classic penicillin paper 17 nor the first Oxford penicillin publication 18 used the word antibiosis.…”

“…The methylation on carbon was the first observation of this process. 34 In summary (Scheme 3), a typical acetate-polymalonate condensation with a methylation prior to cyclization leads to the aromatic structure, 5-methylorsellinic acid (16); orsellinic acid itself is not utilized as a precursor. Lactone formation to 17 is followed by addition of the C 15 farnesyl unit with formation of 18.…”

“…There had been many early investigations of this phenomenon, particularly of the antibiosis between fungi and bacteria; Gosio's observation was a further example, uniquely with a pure compound. Therapeutic possibilities were considered and, to a limited extent, implemented . Strangely, neither Fleming's classic penicillin paper nor the first Oxford penicillin publication used the word antibiosis.…”

Microbial Secondary Metabolites Play Important Roles in Medicine; Prospects for Discovery of New Drugs

“…(instead of m or the correct urn) the name, penicillin, would have predated Fleming's invention by 35 years. Antagonisms between microorganisms were termed "antibiosis" in 1890, eventually leading to the present-day usage of antibiotic [8] . A famous book, Les associations microbiennes: Leurs application thérapeutique, published in 1928, contained some 600 citations concerning antibiosis, including clinical uses [9]. In the introduction to the classic treatise of Florey, et al (Antibiotics), the following paragraph from this book was quoted:…”