Les anesthésiques halogénés protègent-ils contre les lésions myocardiques d'ischémie et de reperfusion ?

Louvier, N.; Lançon, J.P.

doi:10.1016/s0750-7658(05)80726-9

Cited by 7 publications

(2 citation statements)

References 44 publications

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“…The protective effects of volatile anesthetics were also evaluated in a recent study that investigated the mechanisms of IR injury, and identified one such mechanism as intracellular calcium overload. It was suggested that such anesthetics may protect the myocardium from IR injury by altering myocardial calcium fluxes, preserving myocardial energetics, and protecting the region from reactive oxygen species injury [40]. The relatively higher efficiency of enflurane and halothane in comparison to isoflurane regarding these effects has been explained by their effect on myocardial cells: halothane and enflurane primarily decrease intracellular calcium levels by directly acting on the sarcoplasmic reticulum, while isoflurane only decreases transsarcolemnal calcium entry (Fig.…”

Section: General Anesthesiamentioning

confidence: 99%

“…The relatively higher efficiency of enflurane and halothane in comparison to isoflurane regarding these effects has been explained by their effect on myocardial cells: halothane and enflurane primarily decrease intracellular calcium levels by directly acting on the sarcoplasmic reticulum, while isoflurane only decreases transsarcolemnal calcium entry (Fig. 1) [40]. …”

Section: General Anesthesiamentioning

confidence: 99%

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A Review of Anesthetic Effects on Renal Function: Potential Organ Protection

et al. 2017

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Background: Renal protection is a critical concept for anesthesiologists, nephrologists, and urologists, since anesthesia and renal function are highly interconnected and can potentially interfere with one another. Therefore, a comprehensive understanding of anesthetic drugs and their effects on renal function remains fundamental to the success of renal surgeries, especially transplant procedures. Some experimental studies have shown that some anesthetics provide protection against renal ischemia/reperfusion (IR) injury, but there is limited clinical evidence. Summary: The effects of anesthetic drugs on renal failure are particularly important in the context of kidney transplantation, since the conditions of preservation following removal profoundly influence the recovery of organ function. Currently, preservation procedures are typically based on the usage of a cold-storage solution. Some anesthetic drugs induce anti-inflammatory, anti-necrotic, and anti-apoptotic effects. A more thorough understanding of anesthetic effects on renal function can present a novel approach for developing organ-protective strategies. The aim of this review is to discuss the effects of different anesthetic drugs on renal function, with particular focus on IR injury. Many studies have demonstrated the organ-protective effects of some anesthetic drugs, specifically propofol, which indicate the potential of some anesthetics to introduce novel organ protective targets. This is not surprising, since lipid emulsions are major components of propofol, which accumulating data show provide organ protective effects against IR injury. Key Messages: Thorough understanding of the interaction between anesthetic drugs and renal function remains fundamental to the delivery of safe perioperative care and to optimizing outcomes after renal surgeries, particularly transplant procedures. Anesthetics can be repurposed for organ protection with more information about their effects, especially during transplant procedures. Here, we review the effects of different anesthetic drugs – specifically those that contain lipids in their structure, with special reference to IR injury.

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Section: General Anesthesiamentioning

confidence: 99%

Section: General Anesthesiamentioning

confidence: 99%