We give a natural and complete description of Ecalle's mould-comould formalism within a Hopf-algebraic framework. The arborification transform thus appears as a factorization of characters, involving the shuffle or quasishuffle Hopf algebras, thanks to a universal property satisfied by Connes-Kreimer Hopf algebra. We give a straightforward characterization of the fundamental process of homogeneous coarborification, using the explicit duality between decorated Connes-Kreimer and GrossmanLarson algebras. Finally, we introduce a new Hopf algebra that systematically underlies the calculations for the normalization of local dynamical systems.