Leptospirosis Outbreak in 2005: L.T.M.G. Hospital Experience

Mathur, M; De, Anuradha; Turbadkar, Dilip

doi:10.4103/0255-0857.49431

Cited by 18 publications

(7 citation statements)

References 12 publications

(14 reference statements)

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“…There are various reports of leptospirosis outbreaks and its prevalence in various parts of India including the Andamans, Tamil Nadu, Karnataka, Maharashtra, Andhra Pradesh and Orissa; a few cases are also reported from northern India. [26][27][28][29][30][31][32] With leptospirosis prevalent all over the country, the absence of cases in our study, despite presence of conducible environmental conditions, is noteworthy. A significant limitation of this study is the relatively small number of cases, which ideally need molecular diagnostic tests for confirmation.…”

Section: Discussionmentioning

confidence: 99%

Scrub typhus and leptospirosis in rural and urban settings of central India: a preliminary evaluation

et al. 2019

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Scrub typhus and leptospirosis are bacterial zoonotic diseases reported from different parts of India, whose prevalence in Chhattisgarh is unknown. Our study was carried out to delineate the prevalence of these illnesses there and to assess the clinical profiles of rural and urban patients. A total of 169 patients with acute febrile illnesses (AFI) was enrolled in our study from May to December 2018, of whom 35 (20.7%) tested positive for scrub typhus and only one tested positive for leptospirosis by respective IgM ELISA. Scrub typhus seropositivity was higher in rural patients (25.0%) than in urban (18.1%). Patients in the age group 16–30 years were the most commonly affected. The commonest presenting symptoms were fever with headache (68.57%), extreme weakness (57.14%), myalgia/arthralgia (54.29%) and abdominal pain (51.43%). The preliminary evidence for the presence of scrub typhus in Chhattisgarh necessitates its inclusion in the panel of tests for AFI.

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Section: Discussionmentioning

confidence: 99%

Scrub typhus and leptospirosis in rural and urban settings of central India: a preliminary evaluation

et al. 2019

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“…This time lag is consistent with reports of leptospirosis outbreaks after floods. According to studies in India and Hawaii, leptospirosis outbreaks occurred 2 to 3 weeks after a flood [ 14 , 16 , 31 ]. The lag of 2 weeks might reflect the period from contaminated flood water exposure to hospital admission, which spans the incubation period as well as the onset and deterioration of the patient’s condition.…”

Section: Discussionmentioning

confidence: 99%

The non-linear and lagged short-term relationship between rainfall and leptospirosis and the intermediate role of floods in the Philippines

Matsushita

Kim

et al. 2018

PLoS Negl Trop Dis

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BackgroundLeptospirosis is a worldwide bacterial zoonosis. Outbreaks of leptospirosis after heavy rainfall and flooding have been reported. However, few studies have formally quantified the effect of weather factors on leptospirosis incidence. We estimated the association between rainfall and leptospirosis cases in an urban setting in Manila, the Philippines, and examined the potential intermediate role of floods in this association.Methods/Principal findingsRelationships between rainfall and the weekly number of hospital admissions due to leptospirosis from 2001 to 2012 were analyzed using a distributed lag non-linear model in a quasi-Poisson regression framework, controlling for seasonally varying factors other than rainfall. The role of floods on the rainfall–leptospirosis relationship was examined using an indicator. We reported relative risks (RRs) by rainfall category based on the flood warning system in the country. The risk of post-rainfall leptospirosis peaked at a lag of 2 weeks (using 0 cm/week rainfall as the reference) with RRs of 1.30 (95% confidence interval: 0.99–1.70), 1.53 (1.12–2.09), 2.45 (1.80–3.33), 4.61 (3.30–6.43), and 13.77 (9.10–20.82) for light, moderate, heavy, intense and torrential rainfall (at 2, 5, 16, 32 and 63 cm/week), respectively. After adjusting for floods, RRs (at a lag of 2 weeks) decreased at higher rainfall levels suggesting that flood is on the causal pathway between rainfall and leptospirosis.ConclusionsRainfall was strongly associated with increased hospital admission for leptospirosis at a lag of 2 weeks, and this association was explained in part by floods.

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“…Leptospirosis causes significant economic losses in the cattle industry worldwide due to abortion, reduced milk yield and infertility. 2 Leptospira interrogans serovar hardjo is the primary causative agent of bovine Leptospirosis throughout the world and responsible for most of the losses attributable to the disease. 3 The incidence of Leptopsira is especially highest during the seasons of heavy rains and floods.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous detection of LipL32 and LipL21 genes of pathogenic leptospira from serum samples of bovines by multiplex PCR

Meenambigai¹,

Ravikumar²,

Srithar³

et al. 2011

Vet Sci Develop

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Leptospirosis is a worldwide zoonotic disease of cattle associated with pathogenic leptospiral infection. This study focuses in the use of a molecular tool to detect pathogenic leptospiral infection in bovines by targeting the outer membrane proteins LipL32 and LipL21 simultaneously in a multiplex PCR. Sixteen pathogenic reference strains and 10 bovine serum samples were analyzed for simultaneous detection of both genes at appropriate annealing conditions. These findings are suggestive of the fact that multiplex PCR can be used to detect major outer membrane proteins of pathogenic leptospira from serum samples. Further it aided in the differentiation of pathogenic and non-pathogenic species of leptospires too. This study will definitely serve as a valuable tool, as it suggests the importance of LipL32 genes as potential candidates for vaccine development to control animal Leptospirosis.

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Leptospirosis Outbreak in 2005: L.T.M.G. Hospital Experience

Cited by 18 publications

References 12 publications

Scrub typhus and leptospirosis in rural and urban settings of central India: a preliminary evaluation

Scrub typhus and leptospirosis in rural and urban settings of central India: a preliminary evaluation

The non-linear and lagged short-term relationship between rainfall and leptospirosis and the intermediate role of floods in the Philippines

Simultaneous detection of LipL32 and LipL21 genes of pathogenic leptospira from serum samples of bovines by multiplex PCR

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