1965
DOI: 10.1056/nejm196510142731606
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Leptospirosis in the United States

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Cited by 143 publications
(19 citation statements)
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“…1995) but cardiac involvement has not been always actively looked after. However, pulmonary manifestations in leptospirosis have been well recognized (POH & SOH, 1970) but massive haemoptysis and acute respiratory distress syndrome have been rarely reported (HEATH et al, 1965;TURNER & WILLCOX, 1989) except in severe cases of leptospirosis (RAGNAUD et al, 1987;PAFUC et al, 1989) or during epidemic settings in Korea (SHIM et al, 1980), Brazil (RIOS-GONCALVES et al, 1990) or Nicaragua (TREVEJO et aZ., 1998). It may be difficult to relate leptospirosis to PH in cases where fever and respiratory symptoms are not found together with typical signs of liver or renal impairment (TREVEJO et aZ., 1998;O'NEIL et al, 199 1).…”
Section: Discussionmentioning
confidence: 99%
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“…1995) but cardiac involvement has not been always actively looked after. However, pulmonary manifestations in leptospirosis have been well recognized (POH & SOH, 1970) but massive haemoptysis and acute respiratory distress syndrome have been rarely reported (HEATH et al, 1965;TURNER & WILLCOX, 1989) except in severe cases of leptospirosis (RAGNAUD et al, 1987;PAFUC et al, 1989) or during epidemic settings in Korea (SHIM et al, 1980), Brazil (RIOS-GONCALVES et al, 1990) or Nicaragua (TREVEJO et aZ., 1998). It may be difficult to relate leptospirosis to PH in cases where fever and respiratory symptoms are not found together with typical signs of liver or renal impairment (TREVEJO et aZ., 1998;O'NEIL et al, 199 1).…”
Section: Discussionmentioning
confidence: 99%
“…Respiratory symptoms occur usually during the leptospiraemic phase of the disease. The presence ofleptospires in lung tissue has been diversely reported, either rarely (HEATH et al, 1965) or in large number (PARK et al, 1989;ZAKI & SHIEH, 1996). Capillary damage by direct action of a leptospiral toxin has been suggested (POH & SOH, 1970).…”
Section: Discussionmentioning
confidence: 99%
“…La leptospirosis puede presentarse con diferentes formas, grados y combinaciones de compromiso orgá-nico, ya sea como un cuadro febril inespecífico autolimitado, como afección preferente de uno o más órganos involucrados [18][19][20][21][22]24,[28][29][30] , o como una enfermedad grave con compromiso multiorgánico y alta letalidad 31,32 . Clásicamente, se describe como una enfermedad febril bifásica, en que la mayor parte de las manifestaciones clínicas se observan durante el perío-do septicémico, en la primera semana de evolución.…”
Section: Manifestaciones Clínicasunclassified
“…Clásicamente, se describe como una enfermedad febril bifásica, en que la mayor parte de las manifestaciones clínicas se observan durante el perío-do septicémico, en la primera semana de evolución. La meningitis, en cambio, aparece concomitantemente con la nueva onda febril, en la segunda semana del curso clínico (período inmune) 1,2,6,13,14,24,28,30 . En nuestra experiencia 6 , estas manifestaciones clí-nicas se pueden agrupar, constituyendo las formas clínicas clásicamente descritas, como se señala en la Tabla 2.…”
Section: Manifestaciones Clínicasunclassified
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