Leptospirosis

Levett, Paul N.; Edwards, Charles N.

doi:10.1007/978-0-387-09843-2_21

Cited by 3 publications

(4 citation statements)

References 120 publications

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“…The dose of 20 mg of doxycycline/kg represents the cumulative dose for 2 days of treatment according to the recommended dosage of 5 mg of doxycycline/ kg twice a day. 1,[8][9][10] For each experiment, the time of drug administration was designated as 0 hours. A blood sample (3 mL) was obtained by venipuncture from each dog at 1, 2, 4, 8, 12, 24, 36, 48, 60, 72, 96, and 120 hours after drug administration.…”

Section: Methodsmentioning

confidence: 99%

“…Tissue irritation after SC or IM injection can also occur, as with other drugs of the tetracycline group. These potential adverse reactions are limiting factors for treatments for which this tetracycline is the only option, [5][6][7] such as during the carrier phases of Leptospira spp, 8 Ehrlichia canis, 9 Brucella canis, and Haemobartonella canis, 1 which require twice daily administration of the drug for prolonged periods ranging from 21 days to several years. 8,10 Controlled-release formulations of doxycycline may reduce adverse effects and may improve the efficacy during lengthy periods of treatment.…”

Section: Conclusion and Clinical Relevancementioning

confidence: 99%

“…These potential adverse reactions are limiting factors for treatments for which this tetracycline is the only option, [5][6][7] such as during the carrier phases of Leptospira spp, 8 Ehrlichia canis, 9 Brucella canis, and Haemobartonella canis, 1 which require twice daily administration of the drug for prolonged periods ranging from 21 days to several years. 8,10 Controlled-release formulations of doxycycline may reduce adverse effects and may improve the efficacy during lengthy periods of treatment. Because the frequency of administration is decreased, compared with administration of doxycycline alone, ERFs would generate less irritation in the gastrointestinal tract, thereby improving owners' compliance with treatment of their dogs.…”

Section: Conclusion and Clinical Relevancementioning

confidence: 99%

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Pharmacokinetics of an oral extended-release formulation of doxycycline hyclate containing acrylic acid and polymethacrylate in dogs

Ruiz¹,

Gutiérrez²,

Estrada³

2015

ajvr

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Results indicated that both ERFs containing doxycycline, acrylic acid polymer, and polymethacrylate had an adequate pharmacokinetic-pharmacodynamic relationship for a time-dependent drug and a longer release time than doxycycline alone following oral administration in dogs. Given the minimum effective serum doxycycline concentration of 0.26 μg/mL, a dose interval of 48 hours can be achieved for each tested ERF. This minimum inhibitory concentration has the potential to be effective against several susceptible bacteria involved in important infections in dogs. Treatment of dogs with either ERF may have several benefits over treatment with doxycycline alone.

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Section: Methodsmentioning

confidence: 99%

Section: Conclusion and Clinical Relevancementioning

confidence: 99%

Section: Conclusion and Clinical Relevancementioning

confidence: 99%

See 1 more Smart Citation

Pharmacokinetics of an oral extended-release formulation of doxycycline hyclate containing acrylic acid and polymethacrylate in dogs

Ruiz¹,

Gutiérrez²,

Estrada³

2015

ajvr

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“…Leptospira spp. is harboured by animal carriers, rats being the most common (Levett et al, 2009). Other animals like dogs have been speculated to play a vital role in transmission of infection.…”

Section: Introductionmentioning

confidence: 99%

Detection and distribution of anti-leptospiral antibody among dogs and their handlers

2020

Trop Biomed

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A Clinico-Epidemiological Study on Leptospirosis in West Bengal: A Neglected Cause of Acute Febrile Illness

Sikdar¹,

Gupta

Chakraborty

et al. 2022

PIJR

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Introduction: Leptospirosis is a major neglected public health problem and is highly underreported in India. It is a common cause of the acute febrile illness (AFI), but accurate diagnosis is quite challenging and often delayed because of overlapping symptoms with many other infectious diseases, and limited access to laboratory diagnosis. The aim Aim: of the study was to assess the proportion of Leptospira infection among patients suffering from AFI in West Bengal and to analyse socio-demographic characteristics, clinical features, and laboratory parameters of leptospirosis cases. Materials and methods: Serum samples were collected from 350 hospital-admitted patients suffering from AFI (fever >five days ≤ two weeks) but without any identifiable cause and tested for Leptospira IgM using PanBio Leptospira IgM ELISA kit. Clinical features, laboratory parameters and epidemiological data were collected from each patient and analysed. 91(26%) out of 350 fever cases tested positive for Leptospira IgM ELISA. Most of them were Result: male and belonged to the age group of 31–60 years (42.85%) and 16–30 years (30.76%). Common symptoms were fever (100%) myalgia (76.92%), headache (70.32%), icterus (69.23%), vomiting (67.03%) and pain abdomen (65.93%). Conclusion: Leptospirosis is a common cause of acute undifferentiated febrile illness in West Bengal. Our findings demonstrated the importance of active surveillance of leptospirosis among cases of acute febrile illness to facilitate its early detection and prevention of complications.

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Leptospirosis

Cited by 3 publications

References 120 publications

Pharmacokinetics of an oral extended-release formulation of doxycycline hyclate containing acrylic acid and polymethacrylate in dogs

Pharmacokinetics of an oral extended-release formulation of doxycycline hyclate containing acrylic acid and polymethacrylate in dogs

Detection and distribution of anti-leptospiral antibody among dogs and their handlers

A Clinico-Epidemiological Study on Leptospirosis in West Bengal: A Neglected Cause of Acute Febrile Illness

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