Leptospiral pneumonia

Karande, Sunil; Satam, Nitin; Kulkarni, Madhuri; Bharadwaj, Renu; Pol, S.

doi:10.1007/bf02760593

Cited by 5 publications

(6 citation statements)

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“…This is in contrast to other studies where males were predominantly affected owing to more outdoor activities and occupational exposure. [13] The most commonly affected age group in present study was first three decades comprising 62% of the total patients. More than half of the patients had history of prolonged contact with floodwater that hit Mumbai in July 2005.…”

Section: Discussionmentioning

confidence: 86%

“…Hemorrhagic manifestations constitute the common clinical feature in leptospirosis. [1–3] The basic cause of bleeding manifestation in leptospirosis is the disruption of integrity of cell membranes of the endothelial cells lining of the small blood vessels in all parts of the body. Blood clotting mechanisms are also affected by liver cell injury.…”

Section: Introductionmentioning

confidence: 99%

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Thrombocytopenia in leptospirosis and role of platelet transfusion

Sharma¹,

Suryavanshi²

2007

Asian J Transfus Sci

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Aim:The study was designed to find out the incidence of thrombocytopenia in leptospirosis and to correlate thrombocytopenia with other parameters like renal failure, hepatic failure and bleeding manifestation like adult respiratory distress syndrome and to assess the role of platelet transfusion.Materials and Methods:50 cases of leptospirosis during the month of July and August 2005 were retrospectively analyzed. Criteria for selection were Lepto Tek Dri - dot test positive cases of the clinically suspected cases of Leptospirosis. Degree of thrombocytopenia was categorized as severe, moderate and mild. Presence of thrombocytopenia was clinically correlated with parameters like renal dysfunction, hepatic dysfunction and hemorrhagic manifestations (mainly ARDS). Role of platelet transfusion was assessed with reference to presence and degree of thrombcytopenia and hemorrhagic manifestations.Results:Out of total 50 patients 26 were male and 24 were females. Major bleeding manifestation in the form of ARDS was seen in 15 (30%) of patients. 28 (56%) patients had thrombocytopenia and 22 (44%) patients had normal platelet counts. Total number of patients with renal dysfunction was 24 (48%). Only four (18.18%) patients with normal platelet counts had renal dysfunction while 20 (71.42%) patients with thrombocytopenia had renal dysfunction. Only two (9.09%) patients with normal platelet counts and 48 (46.42%) patients with thrombocytopenia had hepatorenal dysfunction. Total number of patients with ARDS was 15 (30%). Of these two (13.33%) had normal platelet count while 13 (86.6%) patients were thrombocytopenic. Total 47 units of platelets were transfused to 12 patients in our study. Of these seven patients with severe thrombocytopenia required total 28 units, two patients with moderate thrombocytopenia required total seven units and patients with mild thrombocytopenia were transfused total 12 units of platelets.Conclusion:It is important to anticipate and recognize thrombocytopenia early in the course of leptospirosis so that appropriate steps can be taken to prevent it and to treat it with platelet transfusion when it develops

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Thrombocytopenia in leptospirosis and role of platelet transfusion

Sharma¹,

Suryavanshi²

2007

Asian J Transfus Sci

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“…It is more prevalent in the developing countries. Hemorrhagic manifestations constitute the common clinical feature in leptospirosis [70]. In cattle, acute hemolytic syndrome of leptospirosis has been reported characterized by fever, icterus, anemia, and hemoglobinuria [71].…”

Section: Blood Transfusionmentioning

confidence: 99%

Leptospirosis: Rising Nuisance for Cattle and Threat to Public Health

Aqib¹,

Ijaz²,

Farooqi³

et al. 2019

Bacterial Cattle Diseases

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Leptospirosis is a communicable disease at farms that results in abortion and pathological changes in animals and human respectively. Disease is majorly spreading through indirect contact with contaminated urine material. The causative agent belongs to Leptospira genus having 21 species, 25 serogroups, and 250 serovars. The prevalence noted at world level is counted to be 41.39% with 30.11% in Asia, 25.62% in Africa, and 46.42% in South Africa. The virulence is attributed to Loa22 protein which is the first protein identified as essential virulence factor. Pathogenesis involves vasculitis following which are direct cytotoxicity and immunological injury resulting in renal failure. Direct examination, PCR, isothermal methods, microscopic agglutination test (MAT) and IgM enzyme-linked immunosorbent assay (ELISA) are diagnostic approaches for leptospirosis. The MAT is a gold standard test for leptospirosis identification. Doxycycline and azithromycin were used as drugs against leptospirosis in mild and severe cases of leptospirosis. Further studies are needed regarding identification, treatment, and effective vaccination.

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“…[1][2][3] Uncommon manifestations include pharyngitis, pneumonitis/hemoptysis, cholecystitis, arthralgia/arthritis, and carditis. [1,2,40] Some patients may remain asymptomatic after this phase. [2] The immune phase (which lasts for up to 30 days) may follow a brief asymptomatic period of 2-3 days, and manifests with recurrence of fever (of 100-105°F) and signs of aseptic meningitis; the patient may have intense headache and retrobulbar pain.…”

Section: Anicteric Leptospirosismentioning

confidence: 99%