Leptospira yasudae sp. nov. and Leptospira stimsonii sp. nov., two new species of the pathogenic group isolated from environmental sources

Casanovas‐Massana, Arnau; Hamond, Camila; Santos, Luciane Amorim; Oliveira, Daiana de; Hacker, Kathryn P.; Balassiano, Ilana Teruszkin; Costa, Federico; Medeiros, Marco Alberto; Reis, Mitermayer Galvão dos; Ko, Albert I.; Wunder, Elsio A.

doi:10.1099/ijsem.0.003480

Cited by 51 publications

(39 citation statements)

References 37 publications

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“…Leptospirosis is caused by a genetically and antigenically diverse group of spirochetes of the Leptospira genus 1-3 . Currently the Leptospir a genus comprises 64 species with more than 300 serovars, with 17 of those species containing strains that can potentially cause severe disease in humans and animals 4,5 . A broad range of mammalian reservoirs harbor the spirochete in their renal tubules shedding the bacteria in their urine for long periods of time 6,7 .…”

Section: Introductionmentioning

confidence: 99%

A Live Attenuated Vaccine Model Confers Cross-Protective Immunity Against Different Species ofLeptospiraspp.

Wunder

Adhikarla

Hamond

et al. 2020

Preprint

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Section: Introductionmentioning

confidence: 99%

A Live Attenuated Vaccine Model Confers Cross-Protective Immunity Against Different Species ofLeptospiraspp.

Wunder

Adhikarla

Hamond

et al. 2020

Preprint

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“…[7] Understanding the diversity of infecting Leptospira has been a major global focus, especially in recent years. Substantial changes in the classification of Leptospira based on whole-genome sequencing have led to the identification of 43 new Leptospira species during the period 2018 to 2020 [8][9][10][11]. In addition, the more robust classification of Leptospira strains beyond the species level using core-genome multi-locus sequence typing (cgMLST) [9,12] and single nucleotide polymorphism typing methods have rapidly expanded our knowledge of the molecular epidemiology of Leptospira.…”

Section: Introductionmentioning

confidence: 99%

12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka

et al. 2021

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Leptospirosis is a ubiquitous zoonotic disease and a major clinical challenge owing to the multitude of clinical presentations and manifestations that are possibly attributable to the diversity of Leptospira, the understanding of which is key to study the epidemiology of this emerging global disease threat. Sri Lanka is a hotspot for leptospirosis with high levels of endemicity as well as annual epidemics. We carried out a prospective study of Leptospira diversity in Sri Lanka, covering the full range of climatic zones, geography, and clinical severity. Samples were collected for leptospiral culture from 1,192 patients from 15 of 25 districts in Sri Lanka over two and half years. Twenty-five isolates belonging to four pathogenic Leptospira species were identified: L. interrogans, L. borgpetersenii, L. weilii, and L. kirschneri. At least six serogroups were identified among the isolates: Autumnalis (6), Pyrogenes (4), Icterohaemorrhagiae (2), Celledoni (1), Grippotyphosa (2) and Bataviae (1). Seven isolates did not agglutinate using available antisera panels, suggesting new serogroups. Isolates were sequenced using an Illumina platform. These data add 25 new core genome sequence types and were clustered in 15 clonal groups, including 12 new clonal groups. L. borgpetersenii was found only in the dry zone and L. weilii only in the wet zone. Acute kidney injury and cardiovascular involvement were seen only with L. interrogans infections. Thrombocytopenia and liver impairment were seen in both L. interrogans and L. borgpetersenii infections. The inadequate sensitivity of culture isolation to identify infecting Leptospira species underscores the need for culture-independent typing methods for Leptospira.

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“…A recent publication in the International Journal of Systematic and Evolutionary Microbiology (IJSEM) described the novel species Leptospira yasudae and Leptospira stimsonii isolated from environmental sources [1]. Two strains were reported for each species: F1 T and B2 for L.…”

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confidence: 99%

Leptospira dzianensis and Leptospira putramalaysiae are later heterotypic synonyms of Leptospira yasudae and Leptospira stimsonii

Casanovas‐Massana

Vincent²,

Bourhy

et al. 2019

International Journal of Systematic and Evolutionary Microbiology

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Leptospira dzianensis and Leptospira putramalaysiae were recently described as novel species and published almost concurrently with Leptospira yasudae and Leptospira stimsonii . Genome comparisons based on average nucleotide identity of the type strain genomes indicate that L. dzianensis and L. putramalaysiae are conspecific with L. yasudae and L. stimsonii , respectively. Based on the rules of priority, L. dzianensis should be reclassified as a later heterotypic synonym of L. yasudae , and L. putramalaysiae should be reclassified as a later heterotypic synonym of L. stimsonii .

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Leptospira yasudae sp. nov. and Leptospira stimsonii sp. nov., two new species of the pathogenic group isolated from environmental sources

Cited by 51 publications

References 37 publications

A Live Attenuated Vaccine Model Confers Cross-Protective Immunity Against Different Species ofLeptospiraspp.

A Live Attenuated Vaccine Model Confers Cross-Protective Immunity Against Different Species ofLeptospiraspp.

12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka

Leptospira dzianensis and Leptospira putramalaysiae are later heterotypic synonyms of Leptospira yasudae and Leptospira stimsonii

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