Leptospira interrogans in wild Boa constrictor snakes from Northeast Brazil peri‑urban rainforest fragments

Rodamilans, Gustavo Macedo; Fonseca, Maísa Santos; Paz, Lucas Nogueira; Fernandéz, Clara Couto; Biondi, Ilka; Lira-da-Silva, Rejâne Maria; Meyer, Roberto; Pinna, Melissa Hanzen; Portela, Ricardo Wagner

doi:10.1016/j.actatropica.2020.105572

Cited by 13 publications

(6 citation statements)

References 30 publications

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“…Among the positive animals were Eastern newts ( Notophthalmus viridescens ), American toads ( Anaxyrus americanus ), Northern Slimy Salamander ( Plethodon glutinosus ), Green frog ( Lithobates clamitans ), American bullfrog ( Lithobates catesbeianus ), Garter snake ( Thamnophis sirtalis ), Northern watersnake ( Nerodia sipedon ), Ringneck snake ( Diadophis punctatus ) and Common snapping turtle ( Chelydra serpentina ). In a previous study from Brazil, using PCR testing and sequencing, 15.21% (7 of 46) of wild Boa constrictor snakes were found to be positive for Leptospira interrogans (Rodamilans et al., 2020). Studies from Brazil and the United States found leptospiral DNA in 16.67% of Geoffroy's side‐necked turtles and 73.5% of Blanding's turtles respectively (Oliveira et al., 2016; Rockwell et al., 2019).…”

Section: Discussionmentioning

confidence: 97%

Detection of pathogenic Leptospira spp. in herpetofauna in Central Appalachia

Verma

Brandt

Runser

et al. 2022

Zoonoses and Public Health

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Leptospirosis is a worldwide zoonosis caused by the pathogenic species of genus Leptospira. The disease has significant impacts on public and animal health. In humans, leptospiral infection can present as a mild flu-like disease or severe life-threatening forms such as Weil's disease or severe pulmonary haemorrhage syndrome. In livestock and companion animals, leptospirosis is often associated with reproductive and/or hepatorenal failure (Adler & de la Peña

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Section: Discussionmentioning

confidence: 97%

Detection of pathogenic Leptospira spp. in herpetofauna in Central Appalachia

Verma

Brandt

Runser

et al. 2022

Zoonoses and Public Health

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“…While primarily a pathogen associated with mammalian hosts, evidence exists of pathogenic and non-pathogenic Leptospira infection in many species of herpetofauna (amphibians and non-avian reptiles) [ 110 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 ]. Human leptospirosis is known to occur with the handling of infected herpetofauna species, particularly during interactions with captive species [ 211 , 212 , 219 ].…”

Section: Leptospirosis Enzootic Persistence In the Environment: Organ...mentioning

confidence: 99%

Leptospirosis and the Environment: A Review and Future Directions

Bradley,

Lockaby

2023

Pathogens

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Leptospirosis is a zoonotic disease of global importance with significant morbidity and mortality. However, the disease is frequently overlooked and underdiagnosed, leading to uncertainty of the true scale and severity of the disease. A neglected tropical disease, leptospirosis disproportionately impacts disadvantaged socioeconomic communities most vulnerable to outbreaks of zoonotic disease, due to contact with infectious animals and contaminated soils and waters. With growing evidence that Leptospira survives, persists, and reproduces in the environment, this paper reviews the current understanding of the pathogen in the environment and highlights the unknowns that are most important for future study. Through a systematic Boolean review of the literature, our study finds that detailed field-based study of Leptospira prevalence, survival, and transmission in natural waters and soils is lacking from the current literature. This review identified a strong need for assessment of physical characteristics and biogeochemical processes that support long-term viability of Leptospira in the environment followed by epidemiological assessment of the transmission and movement of the same strains of Leptospira in the present wildlife and livestock as the first steps in improving our understanding of the environmental stage of the leptospirosis transmission cycle.

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“…While rats are traditionally known as the primary reservoirs for pathogenic Leptospira species, there have been numerous reports on various vertebrate and invertebrate hosts as excreting this pathogen through their urine. Wild and domestic mammals [2,3], livestock [4,5], amphibians [6], reptiles [7] and bats [8] also appear to play significant roles in the spread of Leptospira sp. Human infections typically result from exposure to soil or water contaminated with Leptospira , mostly from the urine of reservoir animals [9].…”

Section: Introductionmentioning

confidence: 99%

Genotyping ofLeptospiraspp. in wild rats leads to first time detection ofL. kirshneriserovar Mozdok in Serbia

Gajdov,

Jokic,

Savic

et al. 2024

Preprint

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This study aimed to investigate the prevalence and molecular characterization of Leptospira species in Belgrade, Serbia, an area where this disease is underexplored. Specifically, the study sought to employ molecular and multilocus sequence typing analyses to fill the gap in understanding the diversity and distribution of Leptospira species within the region. A comprehensive molecular analysis was conducted on kidney samples obtained from Norway rats (Rattus novegicus) in urban environments. The study utilized molecular diagnostic techniques including real-time PCR targeting the lipL32 gene and performing sequence-based typing schemes utilizing adk, icdA, lipL32, lipL41, rrs2 and secY genes. These methodologies were applied to ascertain the presence and characterize different Leptospira species and serotypes, respectively. The findings revealed the presence of two Leptospira species and three separate serotypes in the Belgrade area. Moreover, this study identified the presence of L. kirschneri serovar Mozdok in Serbia for the first time, a significant discovery previously undocumented in the region. This pioneering investigation sheds light on the molecular diversity and prevalence of Leptospira species in Serbia. The study underscores the importance of employing molecular typing methods to gain insights into the epidemiology and characterization of Leptospira species. These findings significantly contribute to both local and global perspectives on leptospirosis epidemiology, providing vital insights for the development of effective control strategies and interventions.

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Leptospira interrogans in wild Boa constrictor snakes from Northeast Brazil peri‑urban rainforest fragments

Cited by 13 publications

References 30 publications

Detection of pathogenic Leptospira spp. in herpetofauna in Central Appalachia

Detection of pathogenic Leptospira spp. in herpetofauna in Central Appalachia

Leptospirosis and the Environment: A Review and Future Directions

Genotyping ofLeptospiraspp. in wild rats leads to first time detection ofL. kirshneriserovar Mozdok in Serbia

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