Leptomeningeal Spread at the Diagnosis of Glioblastoma Multiforme: A Case Report and Literature Review

Jang, Cheolwon; Cho, Byung-Kyu; Hwang, Sung Hwan; Shin, Hyung Jin; Yoon, Soo Han

doi:10.14791/btrt.2022.0013

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Glioblastoma leptomeningeal spread/metastasis, a severe complication of glioblastoma, occurs when tumors infiltrate the cerebrospinal fluid (CSF) and leptomeninges from the brain parenchyma [ 116 – 118 ]. Interestingly, the upregulation of C3 was shown to promote leptomeningeal metastasis [ 119 ].…”

Section: Complement Signaling In Glioblastomamentioning

confidence: 99%

Sphingolipid Signaling and Complement Activation in Glioblastoma: A Promising Avenue for Therapeutic Intervention

Janneh

2024

BioChem

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Glioblastoma is the most common and aggressive type of malignant brain tumor with a poor prognosis due to the lack of effective treatment options. Therefore, new treatment options are required. Sphingolipids are essential components of the cell membrane, while complement components are integral to innate immunity, and both play a critical role in regulating glioblastoma survival signaling. This review focuses on recent studies investigating the functional roles of sphingolipid metabolism and complement activation signaling in glioblastoma. It also discusses how targeting these two systems together may emerge as a novel therapeutic approach.

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Section: Complement Signaling In Glioblastomamentioning

confidence: 99%

Sphingolipid Signaling and Complement Activation in Glioblastoma: A Promising Avenue for Therapeutic Intervention

Janneh

2024

BioChem

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“…6 estimated incidence of LMS with signs and symptoms has been noted to be 2%. 7 It is known as its fatality and being an end-stage complication of GBM. There are no treatment guidelines for GBM with spinal canal extension.…”

Section: Introductionmentioning

confidence: 99%

Yetişkin Bir Hastada Glioblastoma Multiforme’nin Spinal Kord Tutulumu: Bir Olgu Sunumu

2023

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Glioblastoma Multiforme (GBM) is a primary malignant neoplasm of the central nervous system which has aggresive progression and mostly seen in adults. Glioblastoma can be scattered aside by using various ways. Intraparenchymal spread by using white matter tracts is the most known way of spreading. Dissemination of glioblastoma through cerebrospinal fluid (CSF) can happens, causing drop metastases, leptomeningeal spread (LMS) and spinal metastasis. Treatment guideline for LMS in patients with GBM has never been prepared. However total sur¬gical removal of the tumor is the accepted treatment of GBM. Patients with weakness of the spinal cord or little number of solitary metastases may have odds from intervention, but more the disease burden rising, palliative radiotherapy (RT) and chemotherapy (CT) might be more effective. Consequently modern literature accepts the treatment for GBM as combined process of -surgical, concurrent chemoradiotherapy, adjuvant chemotherapy- We present a case in which we applied radiotherapy because of spinal cord metastasis that developed after GBM treatment in an adult patient. Through these observations, we analyze the clinical, histological and therapeutic features of this tumor.

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Intrathecal chemotherapy for leptomeningeal disease in high-grade gliomas: a systematic review

Singh,

Gurses,

Costello

et al. 2024

J Neurooncol

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Leptomeningeal Spread at the Diagnosis of Glioblastoma Multiforme: A Case Report and Literature Review

Cited by 3 publications

References 26 publications

Sphingolipid Signaling and Complement Activation in Glioblastoma: A Promising Avenue for Therapeutic Intervention

Sphingolipid Signaling and Complement Activation in Glioblastoma: A Promising Avenue for Therapeutic Intervention

Yetişkin Bir Hastada Glioblastoma Multiforme’nin Spinal Kord Tutulumu: Bir Olgu Sunumu

Intrathecal chemotherapy for leptomeningeal disease in high-grade gliomas: a systematic review

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