Leptomeningeal metastasis of poorly differentiated uterine cervical adenosquamous carcinoma following reirradiation to metastatic vertebrae

Lu, Yueh‐Feng; Fong, Vai Hong; Wu, Wen-Yih; Wang, Li Ying; Hsieh, Chen‐Hsi

doi:10.1097/md.0000000000006894

Cited by 2 publications

(3 citation statements)

References 15 publications

(19 reference statements)

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“…However, the details of this toxicity were not given. In two other studies, an infectious complication was mentioned as septic shock and pneumonia, similarly without any details [14,18]. We think that this infectious toxicity could have been related to neutropenia.…”

Section: Discussionmentioning

confidence: 82%

Leptomeningeal metastasis in primary uterine cervical cancer: a rare case and review of the literature

et al. 2023

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Objectives. Leptomeningeal metastasis (LM) of primary uterine cervical cancer is rare and treatment options are limited. In this case report and literature review, we aimed to present a patient with cervical cancer with LM and discuss previously reported cases in the literature.Case presentation. Our case was a 58-year-old patient who was initially diagnosed with metastatic primary uterine cervical cancer and treated with chemotherapy and chemoradiotherapy. During follow-up, she developed neurological symptoms, and LM was detected in the craniospinal regions. Cerebrospinal fluid cytology examination has confirmed metastatic disease. The patient was treated with concurrent intrathecal methotrexate and whole-brain radiotherapy (WBRT). A good clinical and cytological response was obtained. However, while intrathecal methotrexate was being continued after WBRT, she succumbed to hematological toxicity before the radiological response could be evaluated.Conclusions. LM is an extremely rare and catastrophic distant spread pattern in patients with cervical cancer.In the literature, a total of 26 patients were reported up to date. Median survival after detection of LM was nine weeks, including our case. Multimodal treatment combinations such as systemic and intrathecal chemotherapy and radiotherapy (RT) were used. However, most of these reports did not have detailed information about toxicity.Despite the combined use of aggressive treatment modalities, patients have limited survival and very high risks of hematologic toxicity. Concurrent use of intrathecal chemotherapy and radiotherapy should be avoided due to increased risk of morbidity.

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Section: Discussionmentioning

confidence: 82%

Leptomeningeal metastasis in primary uterine cervical cancer: a rare case and review of the literature

et al. 2023

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“…A total of 26 reported cases of LM from cervical cancer, including our two cases (Table 1). 2,4,6–23 The age at the initial visit was 30–64 years, with a median age of 47 years. LM from cervical cancer includes all histological subtypes: 15 cases with SCC (58% of all cases), 4 cases with adenocarcinoma (15%), 3 cases with adenosquamous carcinoma (12%), and 4 cases with neuroendocrine cancer (NEC) (15%).…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, LM from cervical carcinoma is extremely rare with only 24 cases reported in the English‐language literature 4,6–12 . Here we present two cases and review previously reported cases.…”

Section: Introductionmentioning

confidence: 85%

Leptomeningeal metastasis from cervical cancer: Report of two cases and a review of the literature

Omori

Ogawa

Oyama

et al. 2021

J of Obstet and Gynaecol

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Leptomeningeal metastases from cervical cancer are extremely rare, with only 24 cases reported in the English‐language literature. Leptomeningeal metastasis (LM) is usually a late event, but it can develop at any stage. A 44‐year‐old woman presented with vertigo, tinnitus, diminution of hearing, and a cervical tumor at the initial visit. She underwent whole brain radiotherapy and systemic chemotherapy. Five months after the initial visit, her condition deteriorated rapidly and she died. A 49‐year‐old woman underwent surgery and pelvic radiotherapy for cervical cancer. She underwent resection of lung metastases 2 years later and received systemic chemotherapy for lymph node metastases 4 years later. Five years after the initial visit, the patient suddenly presented with diplopia, headache, and vomiting; her clinical course was fulminant and she died. Most patients with LM present with diverse clinical manifestations and deteriorate rapidly despite multiple treatment modalities. Gynecologic oncologists should be aware of this rare complication.

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Leptomeningeal metastasis of poorly differentiated uterine cervical adenosquamous carcinoma following reirradiation to metastatic vertebrae

Cited by 2 publications

References 15 publications

Leptomeningeal metastasis in primary uterine cervical cancer: a rare case and review of the literature

Leptomeningeal metastasis in primary uterine cervical cancer: a rare case and review of the literature

Leptomeningeal metastasis from cervical cancer: Report of two cases and a review of the literature

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