Leptina e adiponectina no lúpus eritematoso sistêmico: correlações clínicas e laboratoriais

Barbosa, Vitalina de Souza; Francescantônio, Paulo Luiz Carvalho; Silva, Nílzio Antônio da

doi:10.1016/j.rbr.2014.08.014

Cited by 20 publications

(4 citation statements)

References 25 publications

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“…The inverse correlation between leptin and disease activity as observed in our study might be somewhat intriguing since leptin is assumed to be a strong pro-inflammatory agent increasing the synthesis of pro-inflammatory cytokines such as IL-6, IL-12 and TNF-α [6, 8–11, 13]. In fact, in the literature there are some data on a strong positive correlation between leptin levels and disease activity in other rheumatic diseases, including SLE [4, 49–52, 58], RA [53, 75–77] and ankylosing spondylitis (AS) [64, 78], but to date the clinical significance of this elevation remains unknown. It is thought that serum leptin levels may be either a contributing factor or a marker of disease activity [14, 49, 54].…”

Section: Discussionmentioning

confidence: 56%

“…Particularly, the role of leptin as a potent pro-inflammatory agent has been investigated in spontaneous models of autoimmunity and studies in humans have further delineated the role of leptin in the pathogenesis of autoimmune diseases such as diabetes, inflammatory bowel disease, Behçet’s disease, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) [3–5, 14, 18, 48–54]. Adiponectin, another active hormone released by adipocytes, seems to be an attractive opposite in the field of autoimmune diseases, since it is considered to act as an anti-inflammatory molecule, and recently some studies demonstrated that plasma levels of adiponectin in patients with autoimmune diseases might be related to inflammatory status in their pathogenesis [2, 6, 52, 55–57].…”

Section: Discussionmentioning

confidence: 99%

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Clinical associations of serum leptin and leptin/adiponectin ratio in systemic sclerosis

Michalska-Jakubus

Sawicka

Potembska

et al. 2019

pdia

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A b s t r a c tIntroduction: Leptin and adiponectin have recently received the attention of researchers as attractive biomarkers in systemic sclerosis (SSc) because of their role in the inflammatory process, vascular function and fibrosis. We hypothesized that leptin and adiponectin may be associated with disease activity and severity in patients with SSc. Aim: To compare serum leptin, adiponectin and leptin/adiponectin levels in patients with SSc and healthy controls and to evaluate their possible relationship with frequently used laboratory markers and clinical findings. Material and methods: The study included 48 Caucasian female patients with SSc and 38 healthy controls. Serum concentrations of leptin and adiponectin were measured in patients and controls using commercially available ELISA Kits (Quantikine ELISA Kit R&D Systems, Minneapolis, MN, USA). The results were assessed by the Mann-Whitney U-test and Spearman's correlation test. Results: Leptin and adiponectin levels correlated with body mas index SSc patients (r = 0.495, p = 0.000398 and r = -0.306; p = 0.0342) in contrast to healthy controls (p = 0.070 and p = 0.256, respectively), and, in SSc patients only, a strong negative correlation was observed between leptin and adiponectin serum levels (r = -0.314; p = 0.0312). Diffuse form of the disease (dcSSc) was associated with significantly lower serum adiponectin levels (8638.62 ±10382.62). Active disease was associated with significantly lower leptin concentration (13700.49 ±18293.32) and there was a significant negative correlation between leptin serum level and activity index score (r = -0.342; p = 0.0185). Conclusions:The results of our study indicate that leptin levels might correlate with disease activity and subtype in SSc patients.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Clinical associations of serum leptin and leptin/adiponectin ratio in systemic sclerosis

Michalska-Jakubus

Sawicka

Potembska

et al. 2019

pdia

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“…Leptin exerts its biological actions through the activation of leptin receptor, which belongs to the class 1 cytokine receptor superfamily and are encoded by the diabetes (db) gene . Numerous studies have shown abnormal increase in serum/plasma leptin levels in patients with SLE , but the data regarding association between leptin‐related gene polymorphisms and SLE is still very limited. Afroze et al .…”

Section: Introductionmentioning

confidence: 99%

Association of leptin and leptin receptor gene polymorphisms with systemic lupus erythematosus in a Chinese population

Zhang

Leng

et al. 2017

J Cellular Molecular Medi

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To explore the association of LEP and leptin receptor (LEPR) gene single‐nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese population. Four LEP SNPs (rs11761556, rs12706832, rs2071045 and rs2167270) and nine LEPR SNPs (rs10749754, rs1137100, rs1137101, rs13306519, rs8179183, rs1805096, rs3790434, rs3806318 and rs7518632) were genotyped in a cohort of 633 patients with SLE and 559 healthy controls. Genotyping of SNPs was performed with improved multiple ligase detection reaction (iMLDR). No significant differences were detected for the distribution of allele and genotype frequencies of all 13 SNPs between patients with SLE and controls. The genotype effects of recessive, dominant and additive models were also analysed, but no significant evidence for association was detected. However, further analysis in patients with SLE showed that the TT genotype and T allele frequencies of the LEP rs2071045 polymorphism were nominally significantly higher in patients with pericarditis (P = 0.012, P = 0.011, respectively). In LEPR, the GA/AA genotype and A allele frequencies of the rs1137100 polymorphism were both nominally associated with photosensitivity in patients with SLE (P = 0.043, P = 0.018, respectively). Moreover, the genotype and allele distribution of rs3806318 were also nominally associated with photosensitivity in patients with SLE (P = 0.013, P = 0.008, respectively). No significant differences in serum leptin levels were observed in patients with SLE with different genotypes. In summary, LEP and LEPR SNPs are not associated with genetic susceptibility to SLE, but may contribute to some specific clinical phenotype of this disease; further studies are necessary to elucidate the exact role of LEP and LEPR genes in the pathogenesis of SLE.

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“…5,6 Adiponectin may improve metabolic disorders, including those associated with SLE, due to these anti-inflammatory properties. Higher levels of circulating adiponectin in SLE patients correlate positively with inflammatory markers, 7 and SLE patients are reported to have higher serum adiponectin than healthy controls, while SLE patients with renal dysfunction are reported to exhibit higher serum levels than SLE patients without renal dysfunction. 8 Several studies reports elevated values of leptin and adiponectin in SLE patients.…”

Section: Introductionmentioning

confidence: 99%

High serum leptin and adiponectin levels as biomarkers of disease progression in Egyptian patients with active systemic lupus erythematosus

Kamel

Elazeem

Mohamed

et al. 2023

Int J Immunopathol Pharmacol

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Objectives: Leptin and adiponectin are adipose-derived immune modulators (adipokines) that may contribute to SLE pathology and symptoms. This study aimed to evaluate the associations of serum adiponectin and leptin with clinical manifestations and disease activity in SLE patients. Methods: This is a case control study, where 70 SLE patients and 50 age- and sex-matched healthy controls were enrolled from the Rheumatology and Rehabilitation Department of Beni-Suef University Hospital from June 2020 till April 2022. The SLE disease activity index (SLEDAI) and Systemic Lupus International Collaborative clinics/America Collage of Rheumatology damage index were used to assess disease severity. Laboratory parameters including erythrocyte sedimentation rate (ESR) and serum concentrations of antinuclear antibody (ANA), anti-double stranded DNA, complement 3 and 4, lipids, and C-reactive protein (CRP) were measured and compared between SLE and control groups. Serum adiponectin and leptin were also measured by enzyme-linked immunosorbent assays (ELISA). Results: Compared to healthy controls, SLE patients exhibited significantly greater serum leptin (21.1 vs 3.9 ng/mL, p < 0.001) and adiponectin (18.1 vs 4.8 ng/mL, p < 0.001), and both values were positively correlated with SLEDAI scores ( p = 0.048 and 0.042). Higher serum leptin was significantly associated with lupus nephritis (LN) ( p = 0.048) as well as greater body mass index ( p = 0.010), ESR ( p = 0.002), serum CRP ( p = 0.003), total cholesterol ( p = 0.013), and uric acid ( p = 0.002), while higher adiponectin was significantly associated with LN ( p = 0.046). Conclusion: Serum leptin and adiponectin levels are associated with the clinical and pathological manifestations of SLE, suggesting direct involvement in disease progression and utility as diagnostic biomarkers and therapeutic targets.

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Leptina e adiponectina no lúpus eritematoso sistêmico: correlações clínicas e laboratoriais

Abstract: Patients with SLE had elevated leptin levels, with association with renal involvement. Leptin and adiponectin were not correlated with disease activity. Low levels of leptin have been associated with the presence of LA and aCL.

Cited by 20 publications

References 25 publications

Clinical associations of serum leptin and leptin/adiponectin ratio in systemic sclerosis

Clinical associations of serum leptin and leptin/adiponectin ratio in systemic sclerosis

Association of leptin and leptin receptor gene polymorphisms with systemic lupus erythematosus in a Chinese population

High serum leptin and adiponectin levels as biomarkers of disease progression in Egyptian patients with active systemic lupus erythematosus

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