Leptin resistance does not induce hyperphagia in the rat

Higuchi, Takashi; Mizuno, Akiko; Narita, Kosuke; Ichimaru, Toru; Murata, Takuya

doi:10.1007/s12576-011-0184-5

Cited by 9 publications

(5 citation statements)

References 32 publications

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“…First, it was observed that HFD was able to influence the pattern of food and drink intake of animals. Although highly palatable [41], we observed a reduction in HFD consumption in relation to the standard diet, which is in agreement with the findings of Higuchi et al [42]. The lower intake (g) of HFD may be related to its energy density, in which it has approximately 50% more calories than the standard diet.…”

Section: Discussionsupporting

confidence: 92%

Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety)

et al. 2018

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High-fat-diet (HFD) has been related to metabolic and cardiovascular diseases. Consumption of grapes and their byproducts containing phenolic compounds has been reported due to the benefits they produce for human health. The purpose of this study was to investigate the antioxidant and protective effect of chronic intake of purple grape juice on certain biochemical and physiological changes promoted by the consumption of HFD. Forty male rats were randomly divided into four groups to receive standard or HFD diet and/or conventional (CGJ) or organic grape juice (OGJ) for three months. Dietary intake, body weight gain, cardiometabolic parameters, and serum lipoperoxidation were investigated. Results showed that consumption of CGJ and OGJ changed the pattern of food and drink intake of the animals. There was a reduction in the body weight of animals that consumed grape juices and an increase in the weight gain in HFD and OGJ rats. HFD increased abdominal fat and the abdominal fat/weight ratio, and both grape juices prevented these modifications. HFD increased hepatic enzymes levels (aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT)) and reduced urea. Purple grape juices prevented some of these changes. HFD enhanced lipid peroxidation (thiobarbituric acid reactive substances (TBARS)) in serum and CGJ and OGJ prevented this increase. The consumption of purple grape juice has the potential to prevent and ameliorate most of the alterations provoked by HFD, therefore regular intake of grape products could promote beneficial effects.

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Section: Discussionsupporting

confidence: 92%

Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety)

et al. 2018

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“…3A). Both groups of mice showed no significant difference in the total amount of calories consumed (16,17) (Fig. 3B).…”

Section: High Fat Diet-accelerated Src Kinase-induced Prostate Tumorsmentioning

confidence: 92%

Myristoylation of Src kinase mediates Src-induced and high-fat diet–accelerated prostate tumor progression in mice

Kim

Yang

et al. 2017

Journal of Biological Chemistry

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Exogenous fatty acids provide substrates for energy production and biogenesis of the cytoplasmic membrane, but they also enhance cellular signaling during cancer cell proliferation. However, it remains controversial whether dietary fatty acids are correlated with tumor progression. In this study, we demonstrate that increased Src kinase activity is associated with high-fat diet-accelerated progression of prostate tumors and that Src kinases mediate this pathological process. Moreover, in the prostate regeneration assay, host SCID mice carrying Src(Y529F)-transduced regeneration tissues were fed a low-fat diet or a high-fat diet and treated with vehicle or dasatinib. The high-fat diet not only accelerated Src-induced prostate tumorigenesis in mice but also compromised the inhibitory effect of the anticancer drug dasatinib on Src kinase oncogenic potential We further show that myristoylation of Src kinase is essential to facilitate Src-induced and high-fat diet-accelerated tumor progression. Mechanistically, metabolism of exogenous myristic acid increased the biosynthesis of myristoyl CoA and myristoylated Src and promoted Src kinase-mediated oncogenic signaling in human cells. Of the fatty acids tested, only exogenous myristic acid contributed to increased intracellular myristoyl CoA levels. Our results suggest that targeting Src kinase myristoylation, which is required for Src kinase association at the cellular membrane, blocks dietary fat-accelerated tumorigenesis Our findings uncover the molecular basis of how the metabolism of myristic acid stimulates high-fat diet-mediated prostate tumor progression.

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“…D12450Bi; Research Diets, New Brunswick, NJ), and 36 mice were placed on HFD with 60% of calories coming from fat (catalog D12492i, Research Diets) for the duration of the study. Both diets have been formulated specifically for scientific research and have been used widely in research with rodents [ 14 – 16 ]. Dietary components of the diets used in this study can be found in Supplemental Table S1 (Supplemental Data are available online at www.biolreprod.org ).…”

Section: Methodsmentioning

confidence: 99%

High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice1

Skaznik-Wikiel

Swindle

Allshouse

et al. 2016

Biology of Reproduction

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Excess calorie consumption, particularly of a diet high in fat, is a risk factor for both obesity and reproductive disorders. Animal model studies indicate that elevated dietary fat can influence some reproductive functions independent of obesity. In the current study we sought to determine whether a high-fat diet (HFD) impacts ovarian function, long-term fertility, and local and systemic markers of inflammation independent of obesity. Five-week-old mice were fed either low-fat diet (control group-LF-Ln) or HFD for 10 wk and were divided based on body weight into high-fat obese (HF-Ob: >25 g) and high-fat lean (HF-Ln: <22 g). Ovaries were collected to assess ovarian follicles and to determine the degree of local inflammation. Serum proinflammatory cytokines were also measured. A group of animals was followed for breeding trials for 5 mo while being exposed to LFD or HFD. We found that both 10-wk and 32-wk exposure to HFD resulted in depleted primordial follicles regardless of obesity phenotype. Macrophage counts revealed increased tissue inflammation in the ovary independent of obesity. In addition, serum proinflammatory cytokines were increased in HF-Ln and HF-Ob in comparison to LF-Ln mice. Moreover, HFD had a sustained effect on litter production rate and number of pups per litter regardless of obese phenotype. This study describes for the first time that exposure to HFD causes significant reduction in primordial follicles, compromised fertility, produced higher proinflammatory cytokine levels, and increased ovarian macrophage infiltration, independent of obesity. The negative effects of HFD on primordial follicles may be mediated by increased tissue inflammation.

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Leptin resistance does not induce hyperphagia in the rat

Cited by 9 publications

References 32 publications

Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety)

Biochemical and Physiological Parameters in Rats Fed with High-Fat Diet: The Protective Effect of Chronic Treatment with Purple Grape Juice (Bordo Variety)

Myristoylation of Src kinase mediates Src-induced and high-fat diet–accelerated prostate tumor progression in mice

High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice1

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