Leptin Receptor Antagonists' Action on HDAC Expression Eliminating the Negative Effects of Leptin in Ovarian Cancer

Fiedor, Elżbieta; Zajda, Karolina; Gregoraszczuk, Ewa Ł.

doi:10.21873/cgp.20091

Cited by 8 publications

(5 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study showed that ob/ob and db/db mice exhibited a reduction in sirtuin 1 (SIRT1) expression, a histone deacetylase, in comparison to C57BL/6J mice [58]. Furthermore, a great body of research is now focused on obesity-related carcinogenesis, which occurs due to, among others, hyperleptinemia [59]. For instance, the expression of SIRT1 was upregulated via leptin-induced, nuclear factor, erythroid 2 Like 2 (Nrf2)-dependent signaling in colon cancer [58].…”

Section: Leptin-induced Epigenetic Modifications In Metabolic Disomentioning

confidence: 99%

Molecular Insight into the Interaction between Epigenetics and Leptin in Metabolic Disorders

et al. 2019

View full text Add to dashboard Cite

Nowadays, it is well-known that the deregulation of epigenetic machinery is a common biological event leading to the development and progression of metabolic disorders. Moreover, the expression level and actions of leptin, a vast adipocytokine regulating energy metabolism, appear to be strongly associated with epigenetics. Therefore, the aim of this review was to summarize the current knowledge of the epigenetic regulation of leptin as well as the leptin-induced epigenetic modifications in metabolic disorders and associated phenomena. The collected data indicated that the deregulation of leptin expression and secretion that occurs during the course of metabolic diseases is underlain by a variation in the level of promoter methylation, the occurrence of histone modifications, along with miRNA interference. Furthermore, leptin was proven to epigenetically regulate several miRNAs and affect the activity of the histone deacetylases. These epigenetic modifications were observed in obesity, gestational diabetes, metabolic syndrome and concerned various molecular processes like glucose metabolism, insulin sensitivity, liver fibrosis, obesity-related carcinogenesis, adipogenesis or fetal/early postnatal programming. Moreover, the circulating miRNA profiles were associated with the plasma leptin level in metabolic syndrome, and miRNAs were found to be involved in hypothalamic leptin sensitivity. In summary, the evidence suggests that leptin is both a target and a mediator of epigenetic changes that develop in numerous tissues during metabolic disorders.

show abstract

Section: Leptin-induced Epigenetic Modifications In Metabolic Disomentioning

confidence: 99%

Molecular Insight into the Interaction between Epigenetics and Leptin in Metabolic Disorders

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Therefore, the American authors recently demonstrated that although patients developing postoperative complications had a lower rate of survival at one year follow up (the one year overall survival being of 77.2% for patients which reported postoperative complications, and 89% for patients with uneventful postoperative evolution) and despite the association between extended resections and postoperative complications; the overall survival of patients submitted to extended visceral resections was significantly improved at one year (18). In this respect, other factors influencing the poorer outcomes of patients developing postoperative complications should be investigated (28)(29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

The Influence of the Preoperative Status on the Risk of Postoperative Complications After Cytoreductive Surgery for Advanced-stage Ovarian Cancer

Bacalbaşa

Bălescu

Dimitriu

et al. 2020

In Vivo

View full text Add to dashboard Cite

Background/Aim: The aim of this study was to analyze the influence of preoperative status on the risk of developing further postoperative complications after debulking surgery for advanced-stage ovarian cancer. Patients and Methods: A total of 80 consecutive patients submitted to surgery between 2014 and 2019 for advancedstage ovarian cancer were retrospectively reviewed. Results: Among the 80 cases there were seven patients who developed serious postoperative complications requiring reintervention. Among these cases it seems that association of obesity, poor nutritional status (defined as a lower than 3.5 g/dl serum albumin level) and elderly age were significantly associated with the risk of developing further complications. Conclusion: When selecting the candidates for debulking surgery for advanced-stage ovarian cancer attention should be focused on excluding cases presenting such preoperative risk factors in order to decrease the postoperative morbidity.

show abstract

“…For instance, in a study on human colon cancer cells, leptin was found to up-regulate the expression of histone deacetylase enzyme sirtuin 1 (SIRT1) ( Song et al, 2018 ) . In another study in ovarian cancer, it was reported that leptin modulated HDACs gene expression, in which class I and II HDACs were increased in OVCAR-3 cells, while class II HDAC expression was increased in folliculoma cells ( Fiedor et al, 2018 ). Importantly, animals with dysregulated leptin signalling, the diabetic mouse (db) and obese mouse (ob), showed lower expression of SIRT1 in colon cells, suggesting its involvement in leptin-induced pathogenesis of colon carcinogenesis ( Song et al, 2018 ).…”

Section: Leptin and Methylation Changesmentioning

confidence: 99%

Maternal obesity and ovarian failure: is leptin the culprit?

Sharma

Galvão

2022

Anim. Reprod.

View full text Add to dashboard Cite

At the time of its discovery and characterization in 1994, leptin was mostly considered a metabolic hormone able to regulate body weight and energy homeostasis. However, in recent years, a great deal of literature has revealed leptin’s pleiotropic nature, through its involvement in numerous physiological contexts including the regulation of the female reproductive tract and ovarian function. Obesity has been largely associated with infertility, and leptin signalling is known to be dysregulated in the ovaries of obese females. Hence, the disruption of ovarian leptin signalling was shown to contribute to the pathophysiology of ovarian failure in obese females, affecting transcriptional programmes in the gamete and somatic cells. This review attempts to uncover the underlying mechanisms contributing to female infertility associated with obesity, as well as to shed light on the role of leptin in the metabolic dysregulation within the follicle, the effects on the oocyte epigenome, and the potential long-term consequence to embryo programming.

show abstract

Leptin Receptor Antagonists' Action on HDAC Expression Eliminating the Negative Effects of Leptin in Ovarian Cancer

Abstract: SHLA and Lan2 eliminate the negative effects of leptin on HDAC expression in a cell-type-dependent manner. This is the first report testing leptin receptor blockers as HDAC inhibitors in ovarian cancer cells.

Cited by 8 publications

References 40 publications

Molecular Insight into the Interaction between Epigenetics and Leptin in Metabolic Disorders

Molecular Insight into the Interaction between Epigenetics and Leptin in Metabolic Disorders

The Influence of the Preoperative Status on the Risk of Postoperative Complications After Cytoreductive Surgery for Advanced-stage Ovarian Cancer

Maternal obesity and ovarian failure: is leptin the culprit?

Contact Info

Product

Resources

About