Leptin-induced decrease in food intake in chickens

Denbow, D. Michael; Meade, Sharonda; Robertson, AS; McMurtry, John P.; Richards, Mark; Ashwell, C. M.

doi:10.1016/s0031-9384(99)00258-9

Cited by 133 publications

(61 citation statements)

References 22 publications

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“…Murine leptin injected directly into the chicken central nervous system caused no alteration in food intake (Bungo et al 1999). On the other hand, another study clearly showed that intracerebroventricular administration of human leptin decreased food intake in two chicken genotypes (broiler and layer) at a dose of 10 µg, which is in good agreement with results obtained in mammals (Denbow et al 2000). The contradictory results from all these studies may be attributed also to the source of leptin or to the age of animals used, or to the technique of administration.…”

Section: Resultssupporting

confidence: 74%

Physiologic Effects of Leptin, Insulin and Triamcinolon on Adult Male Japanese Quail

Máčajová¹,

Lamošová²,

Zeman³

2003

Acta Vet. Brno

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The effects of leptin, insulin and triamcinolone on body weight, food intake and some physiological parameters of adult Japanese quail males were investigated in this study. Hormones were administered intramuscularly for 4 days. The birds were weighed and decapitated 24 hours after the last dose. Drug administration did not change the body weight of quail. The weight of testes decreased and the weight of liver increased (P < 0.001) after administration of triamcinolone. Food intake in animals treated with leptin and insulin did not change, but after triamcinolone administration higher food consumption (P < 0.01) was recorded. The activity of alkaline phosphatase in plasma was significantly higher in triamcinolone (P < 0.001) treated group compared to control. After triamcinolone administration the amount of proteins in muscle decreased (P < 0.05). Concentration of leptin in plasma among groups did not differ. The most considerable changes were observed after triamcinolone injection, especially in glucose and lipid metabolism.

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Section: Resultssupporting

confidence: 74%

Physiologic Effects of Leptin, Insulin and Triamcinolon on Adult Male Japanese Quail

Máčajová¹,

Lamošová²,

Zeman³

2003

Acta Vet. Brno

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“…Similar anorectic actions induced by leptin have also been described in other mammalian species, such as mice, pigs and monkeys (Sahu 2004). As in mammals, leptin also depresses food intake in chickens (Denbow et al 2000) and wild birds (Lõhmus et al 2003). Much less information is available on the biological role of leptin in ectotherm vertebrates.…”

Section: Introductionmentioning

confidence: 71%

Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus)

Pedro¹,

Martínez‐Álvarez²,

Delgado³

2006

Journal of Endocrinology

132

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The purpose of the present study was to elucidate the possible role of leptin in food intake and body weight regulation in goldfish. We examined the effects of i.c.v. or i.p. acute leptin administration on food intake in fooddeprived goldfish at different time intervals post-injection (0-2, 2-8 and 0-8 h). Food intake was reduced by i.p. administered leptin (1 µg) at 8 h post-injection, without statistically significant differences after i.c.v. treatment. The present study shows for the first time in a teleost that chronic (10 days) leptin treatment (i.p.) reduces food intake, body weight gain, specific growth rate and food efficiency ratio. Moreover, lipid and carbohydrate metabolism seems to be regulated by leptin in fish.Chronic leptin treatment increased lipid mobilization and carbohydrate storage as hepatic and muscle glycogen. Finally, leptin could mediate its actions on energy homeostasis in fish, at least in part, through interactions with hypothalamic catecholamines, since chronic leptin treatment reduced both hypothalamic noradrenergic and dopaminergic turnover without significant modifications in hypothalamic serotoninergic and neuropeptide Y (NPY) systems. In summary, our results suggest that leptin can regulate feeding behaviour and body weight homeostasis in fish.

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“…that used a recombinant fragment of CLEPR containing the leptin-binding domain (Niv-Spector et al 2005), and studies involving the administration of human leptin to chickens (Denbow et al 2000, Kuo et al 2005. However, some discrepancies exist within the later reports with respect to the possibility that chicken strains selected for rapid growth are leptin resistant, and with an additional publication (Bungo et al 1999) demonstrating nonresponsiveness of young chicks to administration of mouse leptin.…”

Section: Discussionmentioning

confidence: 99%

Monitoring leptin activity using the chicken leptin receptor

Hen¹,

Yosefi²,

Ronin³

et al. 2008

Journal of Endocrinology

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We report on the construction of a leptin bioassay based on the activation of chicken leptin receptor in cultured cells. A human embryonic kidney (HEK)-293 cell line, stably transfected with the full-length cDNA of chicken leptin receptor together with a STAT3-responsive reporter gene specifically responded to recombinant human and Xenopus leptins. The observed higher sensitivity of chicken leptin receptor to the former is in agreement with the degree of sequence similarity among these species (about 60 and 38% identical amino acids between humans and chickens, and between humans and Xenopus respectively). The specific activation of signal transduction through the chicken leptin receptor, shown here for the first time, suggests that the transition of Gln269 (implicated in the Gln-to-Pro Zucker fatty mutation in rats) to Glu in chickens does not impair its activity. Analysis of leptin-like activity in human serum samples of obese and lean subjects coincided well with leptin levels determined by RIA. Serum samples of pre-and post partum cows showed a tight correlation with the degree of adiposity. However, specific activation of the chicken leptin receptor in this assay was not observed with serum samples from broiler or layer chickens (representing fat and lean phenotypes respectively) or with those from turkey. Similar leptin receptor activation profiles were observed with cells transfected with human leptin receptor. Further work is needed to determine whether the lack of leptin-like activity in the chicken serum samples is due to a lack of leptin in this species or simply to a serum level of leptin that is below the detection threshold.

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Leptin-induced decrease in food intake in chickens

Cited by 133 publications

References 22 publications

Physiologic Effects of Leptin, Insulin and Triamcinolon on Adult Male Japanese Quail

Physiologic Effects of Leptin, Insulin and Triamcinolon on Adult Male Japanese Quail

Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus)

Monitoring leptin activity using the chicken leptin receptor

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