Leptin, Galectin-3 and Angiotensin II Type 1 Receptor Polymorphism in Overweight and Obese Patients with Heart Failure – Role and Functional Interplay

Dădârlat-Pop, Alexandra; Pop, Dana; Procopciuc, Lucia Maria; Sitar-Tăut, Adela; Zdrenghea, Dumitru; Bodizs, Gyorgy; Tomoaia, Raluca; Gurzau, Diana; Frîngu, Florina; Susca-Hojda, Silvana

doi:10.2147/ijgm.s301285

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…Different mechanisms are responsible, including the fact that chronic high leptin level leads to leptin insensitivity [ 57 ]. Our results are in line with previous ones [ 11 , 17 , 18 , 22 , 28 , 55 , 58 , 59 , 60 , 61 , 62 ], showing higher levels in obese or diabetic patients and a positive correlation with body mass index (as reported in [ 15 , 28 ]).…”

Section: Discussionsupporting

confidence: 93%

New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes

et al. 2021

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Currently, adipose tissue is considered an endocrine organ, however, there are still many questions regarding the roles of adipokines—leptin and ghrelin being two adipokines. The purpose of the study was to assess the relationship between the adipokines and their ratio with obesity and diabetes. Methods: Sixty patients (mean age 61.88 ± 10.08) were evaluated. Cardiovascular risk factors, leptin, ghrelin, and insulin resistance score values were assessed. The patients were classified according to their body mass index (BMI) as normal weight, overweight, and obese. Results: 20% normal weight, 51.7% overweight, 28.3% obese, and 23.3% diabetic. Obese patients had higher leptin values (in obese 34,360 pg/mL vs. overweight 18,000 pg/mL vs. normal weight 14,350 pg/mL, p = 0.0049) and leptin/ghrelin ratio (1055 ± 641 vs. 771.36 ± 921 vs. 370.7 ± 257, p = 0.0228). Stratifying the analyses according to the presence of obesity and patients’ gender, differences were found for leptin (p = 0.0020 in women, p = 0.0055 in men) and leptin/ghrelin ratio (p = 0.048 in women, p = 0.004 in men). Mean leptin/BMI and leptin/ghrelin/BMI ratios were significantly higher, and the ghrelin/BMI ratio was significantly lower in obese and diabetic patients. In conclusion, obesity and diabetes are associated with changes not only in the total amount but also in the level of adipokines/kg/m2. Changes appear even in overweight subjects, offering a basis for early intervention in diabetic and obese patients.

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Section: Discussionsupporting

confidence: 93%

New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes

et al. 2021

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“…Such properties of leptin signaling deficiency or leptin resistance are a potential factor involved in the pathogenesis of cardiac and vascular dysfunction and/or failure, as well as being recognized as a cause of negative electrical and structural heart remodeling [6,7]. However, not all studies confirm this effect of leptin [6,[8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…www.journals.viamedica.pl/medical_research_journal Adiponectin (ADP) is the only adipocytokine that is recognized as cardioprotective [12]. It is shown to have anti-diabetic, anti-atherogenic, and anti-inflammatory properties in experimental studies [6][7][8][9], and to regulate cardiac and vascular remodeling [7,13]. Nevertheless, in patients with CHF, the ADP level gradually increases with the severity of the disease and a higher ADP level is a factor of poor prognosis (the "adiponectin paradox").…”

Section: Introductionmentioning

confidence: 99%

Selected adipocytokine concentrations in patients hospitalized for exacerbated chronic heart failure

Wawrzeńczyk

Anaszewicz

Szukay

et al. 2022

Medical Research Journal

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Introduction:The role of adipose tissue as energy storage and endocrine organ is an area of interest in the treatment of several diseases. This study aimed to to evaluate blood adiponectin (ADP), leptin, tumor necrosis factor type alpha (TNF-alpha) concentrations, and their prognostic value in patients with exacerbated chronic heart failure (CHF). Methods and results:The following were assessed in 64 consecutive patients hospitalized for exacerbated CHF and a control group of 32 age and sex-matched individuals admitted due to life-limiting symptoms of peripheral artery disease: serum leptin, ADP, TNF-alpha concentrations, and body composition determined by bioelectrical impedance analysis. Compared to the control group, CHF patients had significantly higher blood ADP concentrations, a higher ratio of ADP to fat mass expressed as a percentage of body mass, and lower blood TNF-alpha concentrations and ratios of TNF-alpha to the visceral fat level (VFL). Compared to patients who survived, patients with CHF who died during the one-year follow-up had significantly higher values of ADP and higher ratios of ADP to body surface area. In the Cox regression model, blood ADP concentration was the only independent risk factor in respect of all-cause mortality during the one-year follow-up (HR; 95% CI: 1.16; 1.03-1.31).Conclusions: Patients with CHF present dysregulation in the secretion of ADP and TNF-alpha. Increased blood ADP concentration was associated with an increase in one-year all-cause mortality by 16%.

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The emerging role of leptin in obesity-associated cardiac fibrosis: evidence and mechanism

2022

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Leptin, Galectin-3 and Angiotensin II Type 1 Receptor Polymorphism in Overweight and Obese Patients with Heart Failure – Role and Functional Interplay

Cited by 4 publications

References 29 publications

New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes

New Insights on the Relationship between Leptin, Ghrelin, and Leptin/Ghrelin Ratio Enforced by Body Mass Index in Obesity and Diabetes

Selected adipocytokine concentrations in patients hospitalized for exacerbated chronic heart failure

The emerging role of leptin in obesity-associated cardiac fibrosis: evidence and mechanism

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