Leptin enhances cytokine/chemokine production by normal lung fibroblasts by binding to leptin receptor

Watanabe, Kaoru; Suzukawa, Maho; Arakawa, Sayaka; Kobayashi, Koichi S.; Igarashi, Sayaka; Tashimo, Hiroyuki; Nagai, Hirokazu; Tohma, Shigeto; Nagase, Takahide; Ohta, Ken

doi:10.1016/j.alit.2019.04.002

Cited by 35 publications

(23 citation statements)

References 44 publications

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“…We also observed that treatment of lung stromal cells with a TGFβ1 inhibitor significantly reduced expression of Lox and Fn1 . Leptin, which is an adipokine that is increased in the serum of obese individuals [ 66 ], may also play a role [ 67 ]. In pulmonary fibrosis, lung fibroblasts are activated through increases in microRNAs [ 68 , 69 ], immune cells [ 25 ], and serum cytokines [ 26 ], and further studies are needed to determine the mediators of obesity-induced lung stromal activation.…”

Section: Discussionmentioning

confidence: 99%

Obesity-Activated Lung Stromal Cells Promote Myeloid Lineage Cell Accumulation and Breast Cancer Metastasis

Hillers‐Ziemer

Williams

Janquart

et al. 2021

Cancers

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Obesity is correlated with increased incidence of breast cancer metastasis; however, the mechanisms underlying how obesity promotes metastasis are unclear. In a diet-induced obese mouse model, obesity enhanced lung metastasis in both the presence and absence of primary mammary tumors and increased recruitment of myeloid lineage cells into the lungs. In the absence of tumors, obese mice demonstrated increased numbers of myeloid lineage cells and elevated collagen fibers within the lung stroma, reminiscent of premetastatic niches formed by primary tumors. Lung stromal cells isolated from obese tumor-naïve mice showed increased proliferation, contractility, and expression of extracellular matrix, inflammatory markers and transforming growth factor beta-1 (TGFβ1). Conditioned media from lung stromal cells from obese mice promoted myeloid lineage cell migration in vitro in response to colony-stimulating factor 2 (CSF2) expression and enhanced invasion of tumor cells. Together, these results suggest that prior to tumor formation, obesity alters the lung microenvironment, creating niches conducive to metastatic growth.

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Section: Discussionmentioning

confidence: 99%

Obesity-Activated Lung Stromal Cells Promote Myeloid Lineage Cell Accumulation and Breast Cancer Metastasis

Hillers‐Ziemer

Williams

Janquart

et al. 2021

Cancers

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“…Furthermore, concentrations of CXCL8, which can also induce keratinocyte proliferation, were found to be increased remarkably in the skin of psoriatic patients ( 66 ). It is worth noting that leptin may also stimulate the production of CXCL8 by monocytes ( 67 ). According to these findings, we can reasonably speculate that leptin links obesity and psoriasis potentially via modulating the expression level of diverse chemokines within the circulation.…”

Section: The Impact Of Leptin On Hair and Diverse Skin Diseasesmentioning

confidence: 99%

The Important Role of Leptin in Modulating the Risk of Dermatological Diseases

Cheng

Chang

2021

Front. Immunol.

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It is an indisputable fact that obesity is associated with a series of health problems. One important hallmark of obesity is excessive accumulation of lipids in the adipocyte, especially triglyceride (TG). Currently, the adipocyte has been considered not only as a huge repository of excess energy in the form of fat but also as an important source of multiple hormones and cytokines called adipokines. In obesity, the adipocyte is dysfunctional with excessive production and secretion of pro-inflammatory adipokines, such as tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), and leptin. On the other hand, accumulating evidence has shown that leptin plays a vital role in stimulating angiogenesis, controlling lipid metabolism, and modulating the production of pro-inflammatory cytokines. Furthermore, the various activities of leptin are related to the wide distribution of leptin receptors. Notably, it has been reported that enhanced leptin levels and dysfunction of the leptin signaling pathway can influence diverse skin diseases. Recently, several studies revealed the roles of leptin in wound healing, the hair cycle, and the pathogenic development of skin diseases, such as psoriasis, lupus erythematosus, and dermatological cancers. However, the exact mechanisms of leptin in modulating the dermatological diseases are still under investigation. Therefore, in the present review, we summarized the regulatory roles of leptin in the pathological progression of diverse diseases of skin and skin appendages. Furthermore, we also provided evidence to elucidate the complicated relationship between leptin and different dermatological diseases, such as systemic lupus erythematosus (SLE), psoriasis, hidradenitis suppurativa, and some skin tumors.

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“…Less is known about leptin-mediated molecular mechanisms in human airway inflammation and asthma. However, in recent years, different studies conducted on human bronchial cells [95,96] or mice models of obese asthma [97] have shed some light on this mechanism. Hao et al [95] and Watanabe et al [96] analyzed the effect of leptin on human bronchial epithelial cells' cultures (HBE16) and human lung fibroblasts, respectively (NHLFs).…”

Section: Pro-inflammatory Adipokines: Leptin and Resistinmentioning

confidence: 99%

“…However, in recent years, different studies conducted on human bronchial cells [95,96] or mice models of obese asthma [97] have shed some light on this mechanism. Hao et al [95] and Watanabe et al [96] analyzed the effect of leptin on human bronchial epithelial cells' cultures (HBE16) and human lung fibroblasts, respectively (NHLFs). According to those studies, when HBE16 cells line are exposed to IL-13, mucus secretion would be increased by the upregulation of MUC5AC encoding gene transcription, with this process being mediated by leptin.…”

Section: Pro-inflammatory Adipokines: Leptin and Resistinmentioning

confidence: 99%

Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic

Frontela‐Saseta

González-Bermúdez

García‐Marcos

2020

JCM

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The Western lifestyle is a complex concept that includes the diet as the main axis of different factors which contribute to a detrimental effect on health, lower life expectancy and low quality-of-life. This type of diet is characterized by being high in calories, mainly provided by saturated fats, and rich in sugars that can lead to changes in immune cells and their responsiveness, by different mechanisms that have yet to be totally clarified. Inflammatory processes are perpetuated through different pathways, in which adipose tissue is a major factor. High fat stores in overweight and obesity accumulate energy but the endocrine function is also producing and releasing different bioactive compounds, adipokines, known to be pro-inflammatory and which play an important role in the pathogenesis of asthma. This review therefore explores the latest evidence regarding the adverse effect of the Western diet on adipose tissue inflammation and its causative effect on the asthma epidemic.

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Leptin enhances cytokine/chemokine production by normal lung fibroblasts by binding to leptin receptor

Cited by 35 publications

References 44 publications

Obesity-Activated Lung Stromal Cells Promote Myeloid Lineage Cell Accumulation and Breast Cancer Metastasis

Obesity-Activated Lung Stromal Cells Promote Myeloid Lineage Cell Accumulation and Breast Cancer Metastasis

The Important Role of Leptin in Modulating the Risk of Dermatological Diseases

Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic

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