Leptin: Ein Parameter für metabolische Veränderungen der Herzinsuffizienz

Richartz, Barbara M.; Lotze, Ulrich; Krack, Andreas; Gastmann, Anja; Küthe, Friedhelm; Figulla, Hans‐Reiner

doi:10.1007/s003920170174

Cited by 7 publications

(1 citation statement)

References 26 publications

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“…Chronic heart failure (CHF) is associated with high levels of leptin in humans [133]. Additionally, leptin levels correlate with New York Heart Association (NYHA) functional class, suggesting that leptin levels may be of prognostic value in CHF [134]. It is interesting to note that leptin is an independent predictor of the ventilatory response to exercise in CHF patients with chronic heart failure [135], implicating leptin as a link between the metabolic, respiratory and cardiovascular abnormalities of this disease state; leptin is believed to be a neurohormonal regulator of the respiratory centres in the brain [136], which could partly explain this association.…”

Section: Heart Failurementioning

confidence: 99%

The Emerging Roles of Leptin and Ghrelin in Cardiovascular Physiology and Pathophysiology

Sharma¹,

McNeill²

2005

CVP

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Leptin and ghrelin are novel peptide hormones which are counter-regulatory in the central control of appetite. More recently, it has become clear that these hormones have a range of effects on the cardiovascular system. Leptin increases sympathetic activity, producing a pressor effect when acting on the central nervous system. However, leptin produces vasodilation by an endothelium-dependent mechanism peripherally. Ghrelin decreases sympathetic activity and has a depressor effect when acting on the central nervous system. Peripherally, ghrelin produces vasodilation by an endothelium-independent mechanism. Ghrelin improves left ventricular function and cardiac cachexia in heart failure. Leptin may contribute to cardiac cachexia, and to obesity-related cardiomyopathy by a variety of mechanisms. Leptin has pro-inflammatory, proliferative and calcification promoting effects in the vasculature. Ghrelin has recently been shown to be anti-inflammatory in the vasculature. Leptin may also produce a pro-thrombotic state through stimulation of platelet aggregation and inhibition of coagulation and fibrinolysis. The evidence for and against these effects as well as their pathophysiological significance in obesity hypertension, heart failure, atherosclerosis and thrombosis are discussed.

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Section: Heart Failurementioning

confidence: 99%

The Emerging Roles of Leptin and Ghrelin in Cardiovascular Physiology and Pathophysiology

Sharma¹,

McNeill²

2005

CVP

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Leptin: Sympathetic and cardiovascular effects

Richards

Blalock²,

Liao³

et al. 2003

Curr Cardiol Rep

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Shortly after leptin was first discovered, it was hailed as the key to understanding obesity. However, it didn't take long for investigators to realize that the hormone was more than a feedback signal to inhibit further food intake. Since those early days, leptin has been well characterized in rodents. It exerts an influence in many physiologic processes, including food intake, thermoregulation, fertility, thyroid function, adrenal function, sympathetic nerve activation, renal function, blood vessel tone, and blood pressure. No longer a satiety hormone, it is being looked at from many different perspectives. One such perspective is its influence on the cardiovascular system. This review highlights some of the work in this area.

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Relation between free triiodothyronine/free thyroxine ratio, echocardiographic parameters and mortality in dilated cardiomyopathy

Kozdağ

Ural

Vural

et al. 2005

European J of Heart Fail

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Background: Abnormalities in thyroid function are frequent in patients with heart failure and are associated with increased mortality. However, the relation between thyroid hormone levels and echocardiographic parameters has not been investigated sufficiently. Aim: The aims of this study were to investigate the correlations of thyroid hormone levels with echocardiographic parameters and to evaluate their associations with subsequent mortality in a group of patients with dilated cardiomyopathy (DCMP). Methods: Serum levels of thyroid hormones were measured in 111 consecutive patients with DCMP (35 female, 76 male, mean age: 62 F 12 years). All patients underwent echocardiographic examination and were followed-up for a period of 12 F 8 months. Results: Twenty-three patients (21%) had abnormalities in thyroid function tests. Free triiodothyronine (fT3)/free thyroxine (fT4) ratio was significantly correlated with most of echocardiographic parameters, such as chamber diameters and ejection fraction. Sixteen patients (14%) died during the follow-up period; their fT3/fT4 ratio was significantly lower than the patients who survived (1.31 F 0.37 vs. 2.01 F 0.72, p < 0.001). A fT3/fT4 ratio of V 1.7 was associated with an increased risk of mortality ( p < 0.001), independent of other prognostic markers. Sensitivity, specificity, positive and negative predictivity of fT3/fT4 ratio V 1.7 for cardiac mortality were 100%, 71%, 36% and 100%, respectively. Conclusion: Determination of FT3/FT4 ratio may be a valuable and simple predictor for identification of patients with DCMP who are at high risk of subsequent mortality.

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Leptin: Ein Parameter für metabolische Veränderungen der Herzinsuffizienz

Abstract: Plasma leptin concentrations correlate with the NYHA functional class suggesting anabolic metabolism in NYHA class II and catabolic metabolism in advanced heart failure which might be of prognostic relevance.

Cited by 7 publications

References 26 publications

The Emerging Roles of Leptin and Ghrelin in Cardiovascular Physiology and Pathophysiology

The Emerging Roles of Leptin and Ghrelin in Cardiovascular Physiology and Pathophysiology

Leptin: Sympathetic and cardiovascular effects

Relation between free triiodothyronine/free thyroxine ratio, echocardiographic parameters and mortality in dilated cardiomyopathy

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