Leptin: Does it have any role in childhood asthma?

Güler, Nermin; Kirerleri, E; Öneş, Ülker; Tamay, Zeynep; Salmayenli, Nihal; Darendelıler, Feyza

doi:10.1016/j.jaci.2004.03.053

Cited by 234 publications

(263 citation statements)

References 37 publications

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“…A cumulative concentration response curve was then obtained for each subject. The cumulative concentration response curve data of each subject were then plotted on a semi-log 10 scale curve to determine two quantitative response parameters characterizing the BPR of each subject: (1) the efficacy of the MCH agonist promoting the maximal response (E max ); and (2) its potency or effective dose producing 50% of the maximal response (ED 50 ). E max was determined from the plateau of the dose-response curve, and ED 50 was estimated from the position on the approximate sigmoid curve corresponding to 50% of the plateau.…”

Section: Biochemical Assaysmentioning

confidence: 99%

“…30 Our data clearly indicate that both the efficacy (E max ) of MCH and its potency (ED 50 ) are correlated with the BMI of our female subjects. As these two E max and Effect of obesity on airway hyperreactivity A Chouchane et al ED 50 parameters are good indicators of bronchopulmonary hyperreactivity, which is in turn a good indicator of the potential development of asthma, it is reasonable to speculate that our obese and overweight groups may potentially develop asthma if their weight is not effectively managed preventively with time.…”

Section: Mch Challenge Test and Bmimentioning

confidence: 99%

“…Interestingly, serum leptin is known to increase markedly in obesity, 48,49 and is found at higher levels in asthmatics than in nonasthmatics, 50 regardless of the extent of obesity. In contrast, serum adiponectin levels have the tendency to be reduced in obese subjects.…”

Section: Potential Mechanisms Of Obesity-asthma Relationshipmentioning

confidence: 99%

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Obesity induced bronchopulmonary hyperresponsiveness in Tunisian women

et al. 2010

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Objective: The specific objective of this investigation was to determine whether bronchopulmonary responsiveness (BPR) to methacholine (MCH) was associated with the body mass index (BMI) of Tunisian women. Subjects: In all, 160 healthy nonsmoker women (52 lean, 45 overweight and 63 obese) were recruited and examined in the Clinical Laboratory of Physiology located in the Medical School of Sousse. The average ages ( ± s.e.) of the three categories of lean, overweight and obese subjects were 27.7±1.1, 33.2±1.7 and 37.5±1.3 years, respectively. Their corresponding mean BMIs ( ± s.e.) were 21.9 ± 0.3, 27.7 ± 0.2 and 36.5 ± 0.8 kg m À2 , respectively. Measurements: Before their inclusion into the study, subjects were screened for their lung status by measuring their pulmonary function testing parameters using a whole body plethysmograph. BPR was assessed, using a cumulative concentration response curve technique, by measuring with a spirometer the decrease in forced expiratory volume in 1 s (FEV 1 ) in response to a cumulative dose of MCH. Results: After adjusting for age, significant differences in both FEV 1 and forced vital capacity (VC) were found between the obese and lean groups (Po0.01), as well as between the obese and overweight groups (Po0.01). In addition, forced expiratory flow between 25 and 75% of VC was significantly different between the obese and lean groups (Po0.001), as well as between the lean and overweight groups (P ¼ 0.015). The mean maximum fall of FEV 1 in response to MCH challenge was significantly higher for the obese group (12.0%) than for the overweight (9.8%) or the lean (6.6%) group (Po0.01). Furthermore, the efficacy of the MCH agonist promoting the maximal response (E max ) and its potency or effective dose producing 50% of the maximal response (ED 50 ) were both associated with BMI (the higher the BMI, the higher the E max and the lower the ED 50 ). Conclusion: Our data clearly show that obesity affects pulmonary function performance in Tunisian women by potentially promoting their bronchial hyperreactivity as suggested by the significant correlation between their BMI and the efficacy of the MCH, as well as its potency.

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Section: Biochemical Assaysmentioning

confidence: 99%

Section: Mch Challenge Test and Bmimentioning

confidence: 99%

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Obesity induced bronchopulmonary hyperresponsiveness in Tunisian women

et al. 2010

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“…50,57 Ayrıca bu hormon, inflamatuar immün yanıtın artmasını sağlayan önemli bir özel-liğe de sahiptir. Bu özelliği sayesinde leptin obezitenin patogenezi üzerinde etkili olabilmektedir.…”

Section: Enerji̇ Regülatör Hormonlarunclassified

Interaction of Asthma and Nutrition: Review

Elibol¹,

Şanlıer²

2017

Turkiye Klinikleri Arch Lung

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“…23,95,96 Serum leptin levels are positively correlated to BMI and the prevalence of atopic asthma among children. 97 Obese asthma patients require a longer stay at the ICU because they recover more slowly than non-obese patients with a similar severity status upon admission.…”

Section: Bronchial Asthmamentioning

confidence: 99%

The obese child in the Intensive Care Unit. Update

Fuentes¹,

L²,

et al. 2016

Arch Argent Pediat

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Given that childhood obesity is an epidemic, the frequency of critically-ill patients who are overweight or obese seen at intensive care units has increased rapidly. Adipose tissue is an endocrine organ that secretes a number of protein hormones, including leptin, which stands out because it regulates adipose tissue mass. The presence of arterial hypertension, metabolic syndrome, diabetes mellitus, respiratory disease and chronic kidney disease may become apparent and complicate the course of obese pediatric patients in the Intensive Care Unit. Obesity management is complex and should involve patients, their families and the medical community. It should be coordinated with comprehensive government health policies and implemented in conjunction with a change in cultural context

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Leptin: Does it have any role in childhood asthma?

Cited by 234 publications

References 37 publications

Obesity induced bronchopulmonary hyperresponsiveness in Tunisian women

Obesity induced bronchopulmonary hyperresponsiveness in Tunisian women

Interaction of Asthma and Nutrition: Review

The obese child in the Intensive Care Unit. Update

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