Leptin as a potential prognostic marker of the severity of COVID-19 infection in obese patients

Baltodano-Calle, María J.; Polo-Vasquez, Jhoanna S.; Romani-Pozo, Alina; Gutarra, D Lindo; Guija-Poma, Emilio

doi:10.1016/j.numecd.2021.12.003

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Higher circulating levels of both leptin and CRP have been demonstrated to be correlated with disease severity and poor prognosis in patients with COVID-19 [ 173 - 175 ]. In a recently published report from Italy, COVID-19 patients with pneumonia had increased circulating levels of leptin and IL-6 and lower adiponectin levels than age- and sex-matched healthy controls [ 176 ].…”

Section: Potential Indicators Of Obesity and Inflammationmentioning

confidence: 99%

“…van der Voort et al reasoned that SARS-CoV-2 infection, by inducing higher leptin production, might overactivate leptin receptors in pulmonary tissue, ultimately enhancing local inflammation in the lungs [ 177 ]. Higher leptin levels could also activate monocytes and thus upregulate the expression of pro-inflammatory cytokines in monocytes, resulting in dysregulation of immune responses, finally leading to ARDS and multiple organ failure [ 173 , 180 ]. As mentioned earlier, leptin receptors are present in all immune cells.…”

Section: Potential Indicators Of Obesity and Inflammationmentioning

confidence: 99%

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Infections and immunity: associations with obesity and related metabolic disorders

Ray

Bonorden

Pandit

et al. 2023

JPTM

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About one-fourth of the global population is either overweight or obese, both of which increase the risk of insulin resistance, cardiovascular diseases, and infections. In obesity, both immune cells and adipocytes produce an excess of pro-inflammatory cytokines that may play a significant role in disease progression. In the recent coronavirus disease 2019 (COVID-19) pandemic, important pathological characteristics such as involvement of the renin-angiotensin-aldosterone system, endothelial injury, and pro-inflammatory cytokine release have been shown to be connected with obesity and associated sequelae such as insulin resistance/type 2 diabetes and hypertension. This pathological connection may explain the severity of COVID-19 in patients with metabolic disorders. Many studies have also reported an association between type 2 diabetes and persistent viral infections. Similarly, diabetes favors the growth of various microorganisms including protozoal pathogens as well as opportunistic bacteria and fungi. Furthermore, diabetes is a risk factor for a number of prion-like diseases. There is also an interesting relationship between helminths and type 2 diabetes; helminthiasis may reduce the pro-inflammatory state, but is also associated with type 2 diabetes or even neoplastic processes. Several studies have also documented altered circulating levels of neutrophils, lymphocytes, and monocytes in obesity, which likely modifies vaccine effectiveness. Timely monitoring of inflammatory markers (e.g., C-reactive protein) and energy homeostasis markers (e.g., leptin) could be helpful in preventing many obesity-related diseases.

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Section: Potential Indicators Of Obesity and Inflammationmentioning

confidence: 99%

Section: Potential Indicators Of Obesity and Inflammationmentioning

confidence: 99%

Infections and immunity: associations with obesity and related metabolic disorders

Ray

Bonorden

Pandit

et al. 2023

JPTM

View full text Add to dashboard Cite

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Can adipokines predict clinical prognosis and post-COVID lung sequelae?

Esendağlı

Topçu

Gül

et al. 2023

Respiratory Investigation

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Exploring the Network between Adipocytokines and Inflammatory Response in SARS-CoV-2 Infection: A Scoping Review

Nigro,

D’Agnano,

Quarcio

et al. 2023

Nutrients

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Adipose tissue is actually regarded as an endocrine organ, rather than as an organ that merely stores energy. During the COVID-19 pandemic, obesity has undoubtedly emerged as one of the most important risk factors for disease severity and poor outcomes related to SARS-CoV-2 infection. The aberrant production of cytokine-like hormones, called adipokines, may contribute to alterations in metabolism, dysfunction in vascular endothelium and the creation of a state of general chronic inflammation. Moreover, chronic, low-grade inflammation linked to obesity predisposes the host to immunosuppression and excessive cytokine activation. In this respect, understanding the mechanisms that link obesity with the severity of SARS-CoV-2 infection could represent a real game changer in the development of new therapeutic strategies. Our review therefore examines the pathogenic mechanisms of SARS-CoV-2, the implications with visceral adipose tissue and the influences of the adipose tissue and its adipokines on the clinical behavior of COVID-19.

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Leptin as a potential prognostic marker of the severity of COVID-19 infection in obese patients

Cited by 3 publications

References 10 publications

Infections and immunity: associations with obesity and related metabolic disorders

Infections and immunity: associations with obesity and related metabolic disorders

Can adipokines predict clinical prognosis and post-COVID lung sequelae?

Exploring the Network between Adipocytokines and Inflammatory Response in SARS-CoV-2 Infection: A Scoping Review

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