Leptin and Thyrotropin Relationship Is Modulated by Smoking Status in Euthyroid Subjects

Lucas, Anna; Granada, María Luisa; Olaizola, Izaskun; Castell, Conxa; Julián, María Teresa; Pellitero, Sílvia; Roca, Josep; Puig-Domingo, Manel

doi:10.1089/thy.2012.0506

Cited by 12 publications

(8 citation statements)

References 55 publications

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“…It is recognised that leptin is a component of a series of important thyroid cell processes, including the regulation of TSH expression [31] and the development of autoimmunity [32, 33], and that serum leptin levels may be related to the presence of insulin resistance in hypothyroidism [34] and to other diseases that may be associated with thyroid disorders, such as obesity and insulin resistance. However, the present study is the first to investigate the occurrence of genetic changes in LEP and LEPR genes in DTC, which might be a likely link between obesity and thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism inLEPandLEPRMay Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer

Marcello

Calixto

Almeida

et al. 2015

International Journal of Endocrinology

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Purpose. To understand the role of polymorphisms in the LEP (rs7799039 and rs2167270) and LEPR (rs1137101 and rs1137100) genes in DTC susceptibility and their effect on leptin levels. Methods. We studied 153 patients with DTC and 234 controls through TaqMan SNP Genotyping and ELISA, comparing these data to the clinicopathological data of patients with DTC. Results. Patients with AA genotype of rs7799039 had higher levels of serum leptin (9.22 ± 0.98 ng/mL) than those with AG genotype (10.07 ± 0.60 ng/mL; P = 0.005). Individuals with AG genotype of rs2167270 also produced higher serum leptin levels (10.05 ± 0.59 ng/mL) than the subjects with GG genotype (9.52 ± 0.79 ng/mL; P < 0.05). A multivariate logistic regression adjusted for gender, age, and BMI showed that the AG genotype of rs7799039 was an independent risk for DTC (OR, 11.689; P = 0.0183; 95% CI, 1.516–90.119). Similarly, AG and GG genotypes of rs1137101 increased the susceptibility to DTC (OR, 3.747; P = 0.027; 95% CI, 1.161–12.092 and OR, 5.437; P = 0.013; 95% CI, 1.426–20.729). Conclusions. We demonstrated that rs7799039 and rs2167270 polymorphisms modify the serum leptin concentrations in patients with DTC. Furthermore, polymorphisms rs7799039 and rs1137101 increase the risk of DTC development, although they do not correlate with tumor aggressiveness.

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Section: Discussionmentioning

confidence: 99%

Polymorphism inLEPandLEPRMay Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer

Marcello

Calixto

Almeida

et al. 2015

International Journal of Endocrinology

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“…An evidence that the reality might be even more complex provide the recent findings of Lucas and cols. of a possible effect of smoking on the relationship between leptin and TSH (26).…”

Section: Discussionmentioning

confidence: 99%

The prevalence of the metabolic syndrome increases through the quartiles of thyroid stimulating hormone in a population-based sample of euthyroid subjects

Shinkov¹,

Borissovа²,

Кovatcheva³

et al. 2014

Arq Bras Endocrinol Metab

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Objective: The aim of the study was to assess the prevalence and characteristics of metabolic syndrome (MetS) and its elements in relation to TSH in euthyroid subjects. Materials and metho ds: In the cross-sectional study, 2,153 euthyroid adults, 47.2 ± 14.5 years (20-94) with no current antithyroid or thyroid replacement therapy were enrolled. All participants filled a questionnaire on past and current morbidities, medication and smoking. Body weight, height, waist circumference, serum TSH, glucose and lipids were measured. The subjects were stratified by quartiles of TSH (QTSH) and the prevalence of the MetS elements was calculated. MetS RESUMOObjetivo: O objetivo deste estudo foi avaliar a prevalência e características da síndrome metabólica (MetS) e seus elementos em relação ao TSH em sujeitos eutireoides. Materiais e mé-todos: Foram analisados, em um estudo transversal, 2.153 adultos eutiroides, de 47,2 ± 14,5 anos (20-94) sem terapia antitiroidiana ou de reposição. Todos os participantes preencheram um questionário sobre doenças atuais e passadas, medicações e tabagismo. O peso corporal, altura, circunferência da cintura, TSH, glicose e lipídios séricos foram medidos. Os sujeitos foram estratificados em quartis de TSH (QTSH) e a prevalência dos elementos da MetS foram calculados. Os critérios da MetS foram determinados pela IDF 2005. Resultados: A prevalência de sobrepeso foi de 37,2% (35,2-39,2), de obesidade -25,1% (23,9), obesidade abdominal -61,4% (59,3-63,5), hipertensão -42,1% (38,9-43,1), diabetes/aumento da glicose de jejum -13,6% (12,1-15), baixo colesterol HDL -27,6% (25,7-29,5), hipertrigliceridemia -24,1% (22,3-25,9), 2% (30,2). A MetS foi mais prevalente no QTSH mais alto (34,9%; 30,9-38,9) do que no mais baixo (27%; 23,3-30,9), p < 0,001, assim como o baixo [28][29][30][31][32][33][34][35]9 contra 25%,21,7; p < 0,001) e hipertrigliceridemia (26,8%; 23-30,5 contra 20,4%, 17-23,8; p = 0,015). Cada QTSH aumentou o risco MetS em 14%, p < 0,001, de hipertrigliceridemia em 20%, p = 0,001 e de baixo LDL-C em 9%, p = 0,042. Outros fatores significativos para a MetS foram idade, sexo masculino e obesidade. Conclusão: A prevalência de MetS aumentou com um maior QTSH dentro da variação eutiroide, principalmente por aumento da dislipidemia. Arq Bras Endocrinol Metab. 2014;58(9):926-32 Descritores Síndrome metabólica; função tiroidiana; eutiroidismo; MetS; elementos da síndrome metabólica

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“…There is solid evidence that current smokers have significantly lower serum TSH levels than non-smokers, probably in relation with leptin levels [23]. This effect is dose-dependent, disappears slowly after smoking cessation and is not associated with iodine intake [24].…”

mentioning

confidence: 99%

Thyroid Function Variability in a Cohort of Healthy Pregnant Women: Effect of BMI, Smoking and Iodized Salt Consumption

Velasco¹,

Soldevila

MartínezMondejar

et al. 2020

LOJPCR

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Introduction: It remains unclear to what extent intrinsic maternal characteristics, lifestyle or diet and dietary supplements contribute to explain the variability of maternal thyroid function. The aim of this study was to analyse the effect of age, parity, pregestational body mass index (BMI), beta human chorionic gonadotropin (β-hCG), thyroid autoantibodies, smoking habit and use of vitamins/supplements on maternal thyroid function variability throughout pregnancy. Methods:A prospective, observational study was carried out including 339 healthy pregnant women from their first to their third trimester. Clinical and biological variables were registered at each stage. Univariate correlation and multiple linear regression analysis for thyroid parameters were performed in the three trimesters.Results: Thyrotropin (TSH) in the first trimester (1T) was dependent on free thyroxine (FT4), maternal age, β-hCG and smoking habit. FT4 levels in the 1T were significantly lower in obese women (0.937±0.078ng/dl), compared with overweighed (0.981±0.14ng/dl) and normal weight women (0.989± 0.98ng/dl) (p=0.012). Multiple linear regression showed that FT4 in all trimesters is significantly dependent on pregestational BMI. Additionally, TSH and FT4 in the 1T were significantly related to TSH and FT4 levels in second and third trimesters, respectively. All studied factors influenced TSH with different degree all-over the pregnancy. Dietary supplements did not modify maternal thyroid function. Conclusion:FT4 availability during the first half of the gestation can be hindered by maternal overweight/obesity. Beside age, obesity and smoking, TSH and FT4 in the 1T are very important regarding thyroid function variability in further stages of the pregnancy.

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Leptin and Thyrotropin Relationship Is Modulated by Smoking Status in Euthyroid Subjects

Abstract: Leptin is an independent predictor of TSH concentration variations only in euthyroid smoker subjects of both sexes at all ranges of BMI, but not in nonsmokers. Age, smoking status, and positive thyroid autoimmunity also influenced TSH variability.

Cited by 12 publications

References 55 publications

Polymorphism inLEPandLEPRMay Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer

Polymorphism inLEPandLEPRMay Modify Leptin Levels and Represent Risk Factors for Thyroid Cancer

The prevalence of the metabolic syndrome increases through the quartiles of thyroid stimulating hormone in a population-based sample of euthyroid subjects

Thyroid Function Variability in a Cohort of Healthy Pregnant Women: Effect of BMI, Smoking and Iodized Salt Consumption

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