Leptin and Insulin Resistance in Young Adult Obese Females: Effect of Eight Weeks Resistance Training

Khalili, Soraya; Nuri, Reza; Moghadassi, Mehrzad; Mogharnasi, Mehdi

doi:10.5171/2014.665365

Cited by 3 publications

(1 citation statement)

References 24 publications

(25 reference statements)

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“…Leptin exerts an inhibitory effect on food intake and increases energy expenditure through thermogenesis and physical activity [12] . The idea of leptin as an insulin sensitizing hormone and leptin deficiency or resistance as a potential link between obesity and diabetes has been reviewed recently [13] .…”

Section: Introductionmentioning

confidence: 99%

The Association between Resistin, Leptin and Adiponectin with Obesity and Type 2 Diabetes Mellitus

ABD-ELREHEEM¹,

RASHEED²,

ABD-ELREHEEM³

2019

The Medical Journal of Cairo University

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Background: Obesity is an important public health concern among all age groups in the world and is a risk to develop insulin resistance and associated metabolic diseases. Fat tissue exerts important endocrine functions, which are mediated by a complex network of various soluble factors, derived from adipocytes, called adipocytokines including tumor necrosis factor a (TNF-α), Interleukin (IL) 6, leptin, adiponectin and resistin. Some adipokines play a major role in insulin resistance and cardiovascular complications associated with obesity, especially central or visceral obesity. Aim of Study:The aim of this study was to discover the role of leptin, adiponectin and resistin as a link between obesity and insulin resistance type 2 diabetes through assessment of their levels in normal weight, obese before and after weight reduction as well as obese diabetic subjects.Patients and Methods: Forty-five female subjects divided into four groups, 15 subjects with normal weight-as control group (group I), 15 obese subjects (group II), 10 subjects from group II followed a weight reduction regimen for 2 months (group III) and 15 obese diabetic subjects (group VI). Serum insulin, leptin, adiponectin and resistin were measured by ELISA. Lipid profile was measured by a spectrophotometric method. Anthropometric measurements were also performed. Results:The study showed that the obese and obese diabetic subjects have got higher serum leptin and resistin levels when compared with controls. In contrast, serum adiponectin concentration was significantly lower in obese before diet and obese diabetic subjects when compared to the control group. After weight loss, significant improvement has been observed in all parameters. The findings from bivariate correlation analysis were further explored using multiple linear regression analysis which confirmed that resistin rather than adiponectin and leptin was an important determinant of insulin resistance.Conclusion: This study concluded that even modest weight loss can improve metabolic risk factors through modulation of some adipokines.

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Section: Introductionmentioning

confidence: 99%

The Association between Resistin, Leptin and Adiponectin with Obesity and Type 2 Diabetes Mellitus

ABD-ELREHEEM¹,

RASHEED²,

ABD-ELREHEEM³

2019

The Medical Journal of Cairo University

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A Comparison of the Effects of Resistance and Endurance Training Protocols on Serum Irisin Level and Alkaline Phosphatase Activity in Sedentary Obese Women

Poutafkand

Marefati

TaheriChadorneshin

2020

Polish Journal of Sport and Tourism

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Introduction. Studies have revealed that the anabolic effect of irisin on bone is mediated by an increase in alkaline phosphatase. However, few studies have investigated the interactive effect of irisin on alkaline phosphatase after exercise training. Therefore, the present study aimed to compare the impact of endurance and resistance training protocols on serum irisin concentration and total alkaline phosphatase activity in sedentary obese women. Material and methods. Forty-five sedentary obese women (age: 48.96 ± 5.2 years, body mass index 32.24 ± 3.76 kg/m2) were randomly assigned to control, endurance, and resistance groups. Endurance (45 to 75 minutes at an intensity corresponding to 50 to 80% of heart rate reserve) and resistance exercise training (3 sets, 10-15 repetitions at an intensity corresponding to 50 to 65% of one-repetition maximum) were conducted for 8 weeks, 3 days per week. Maximal oxygen consumption (VO2max) was estimated using the modified Bruce protocol treadmill test. Fasting blood samples were taken before the first and 48-hr after the last exercise training sessions. The serum concentrations of irisin and total alkaline phosphatase activity were measured using the sandwich ELISA method and photo-metric method, respectively. Results. Both endurance and resistance exercise training protocols caused a significant reduction in BMI and BFP of obese women. In contrast, VO2max significantly increased after both exercise training protocols. However, neither endurance nor resistance training protocols had a significant impact on the serum concentrations of irisin and total alkaline phosphatase activity. No significant inter-group differences were observed between the subjects’ BMI, BFP, VO2max, total alkaline phosphatase, and irisin at the end of protocols. Conclusions. The finding of the current study revealed that neither of the training protocols had a significant impact on bone anabolic parameters. However, performing these types of exercise is suggested for weight management in obese women.

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Comparison of Concurrent Aerobic, Resistance and Combination (Aerobic + Resistance) Training on Serum Levels of Leptin, Atherogenic Index of Plasma and Cardiovascular Risk Factors in Obese Inactive Student Girls

Rezaei,

Siahkouhian,

Seifi-Skishahr

et al. 2022

Pajouhan Sci J

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Leptin and Insulin Resistance in Young Adult Obese Females: Effect of Eight Weeks Resistance Training

Cited by 3 publications

References 24 publications

The Association between Resistin, Leptin and Adiponectin with Obesity and Type 2 Diabetes Mellitus

The Association between Resistin, Leptin and Adiponectin with Obesity and Type 2 Diabetes Mellitus

A Comparison of the Effects of Resistance and Endurance Training Protocols on Serum Irisin Level and Alkaline Phosphatase Activity in Sedentary Obese Women

Comparison of Concurrent Aerobic, Resistance and Combination (Aerobic + Resistance) Training on Serum Levels of Leptin, Atherogenic Index of Plasma and Cardiovascular Risk Factors in Obese Inactive Student Girls

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