Leptin and IGF-I levels in unconditioned male volunteers after short-term exercise

Elias, Alan N.; Pandian, M. R.; Wang, L; Suárez, Erick; James, N.; Wilson, Archie F.

doi:10.1016/s0306-4530(99)00070-0

Cited by 52 publications

(29 citation statements)

References 33 publications

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“…This finding has been confirmed in several other studies, demonstrating increases of tIGF-I ranging from ∼10 to 30% and peaking after 5–10 min of moderate- to high-intensity exercise [2, 3, 4, 5, 6]. After graded intensity exercise tIGF-I increases first at higher intensity [7, 8, 9, 10]. Thus, a bout of exercise is unique in inducing such a fast and marked increase in tIGF-I.…”

Section: Acute Changes In Total Igf-i In Relation To a Bout Of Exercisesupporting

confidence: 80%

Exercise and Circulating Insulin-Like Growth Factor I

Berg

Bang²

2004

Horm Res Paediatr

102

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Determinations of serum concentrations of total insulin-like growth factor I (tIGF-I) are important in the diagnosis, monitoring of treatment and safety evaluation of patients with growth disorders and/or metabolic disease. It is well established that tIGF-I status varies over time. Changes in tIGF-I levels in relation to an acute bout of exercise or repeated bouts, known as training, are likely to contribute to this variation. Serum tIGF-I has also been found to be of predictive value in growth prediction models employed before the start of growth hormone (GH) treatment. Furthermore, IGF-I generation tests have been suggested to be of value in the assessment of the growth response to GH administration in patients suspected of GH deficiency with or without some degree of GH insensitivity. This is discussed elsewhere in this issue. Recent progress in our understanding of growth hormone-dependent and -independent expression of the IGF1 gene in skeletal muscle and the role of sufficient energy intake during training for muscle and liver generation of IGF-I raises important questions regarding their relative contribution to the circulating pool of IGF-I. The present review is focused on circulating levels of tIGF-I in relation to a single bout of exercise or to a period of training. In addition, the expression of IGF-I locally in muscle in response to these stimuli will be discussed.

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Section: Acute Changes In Total Igf-i In Relation To a Bout Of Exercisesupporting

confidence: 80%

Exercise and Circulating Insulin-Like Growth Factor I

Berg

Bang²

2004

Horm Res Paediatr

102

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“…Previous studies, although not entirely consistent, tend to indicate that circulating IGF-I has a biphasic response to acute exercise (3,6,13). First, serum levels increase to a small but significant degree in the first 10 -20 min, but, as exercise progresses, IGF-I levels fall.…”

Section: Discussionmentioning

confidence: 96%

Effect of rhIL-6 infusion on GH→IGF-I axis mediators in humans

Nemet

Eliakim²,

Zaldivar³

2006

American Journal of Physiology-Regulatory, Integrative and Comp

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Exercise leads to simultaneous increases in mediators signaling apparently antagonistic functional responses such as growth factors and inflammatory mediators. The aim of the present study was to demonstrate the physiological effect of IL-6 on circulating components of the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis. Twelve men (ages 26 ± 2 yr) were divided into two groups ( n = 6 in each group), receiving either albumin or recombinant human (rh) IL-6 infusion. IL-6 was infused via an antecubital vein, and a contralateral antecubital vein was used for blood sampling. The IL-6 dose was chosen to reach plasma levels of IL-6 characteristic of intense exercise (5 μg/h, for 3 h, resulting in plasma levels of 100 pg/ml). Blood samples for GH, GH binding protein, IGF-I, and IGF binding protein (IGFBP)-1 and -3 were collected at baseline, 30 min, and 1, 2, 3, 4, 5, and 8 h after the beginning of the rhIL-6 infusion. IL-6 levels increased only in the rhIL-6-infused group ( P < 0.0005) and returned to baseline after the infusion was stopped. IL-6 infusion led to a significant increase in GH, peaking 1 h after the beginning of infusion ( P < 0.001). A decrease in total IGF-I levels was noted only in the rhIL-6-infused group ( P < 0.027). An initial decrease in IGFBP-1 levels was noted in both groups during infusion ( P < 0.03). Following the initial decrease, there was a significant increase in IGFBP-1 levels only in the IL-6-infused participants, peaking at 2 after the infusion cessation ( P < 0.001). IL-6 infusion had no effect on GH binding protein, IGFBP-3, and acid-labile subunit levels. rhIL-6 levels similar to the levels found after strenuous exercise induced a typical exercise-associated GH→IGF-I axis response (increase GH, decreased IGF-I, and elevated IGFBP-1). The results suggest that IL-6 plays a role in the GH→IGF-I response to intense exercise.

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“…Such fact is probably due to the increase in the production of non-ester fatty acids during exercise, reflecting a catabolic state of the adipose tissue, and hence, lower secretion of leptin (32)(33) . The authors suggested a decrease in the circulating concentration of this hormone in acute response to exercise (~3ng/ ml), even in the lack of weight loss.…”

Section: Non-alcoholic Fat Liver Diseasementioning

confidence: 99%

Tratamento multidisciplinar reduz o tecido adiposo visceral, leptina, grelina e a prevalência de esteatose hepática não alcoólica (NAFLD) em adolescentes obesos

Dâmaso

Tock

Tufik

et al. 2006

Rev Bras Med Esporte

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The aim of this study was to assess the changes promoted by a multidisciplinary therapy in ghrelin and leptin concentrations, visceral adiposity and non-alcoholic fat liver disease-NAFLD, in obese adolescents. A total of 28 obese adolescents, 16 girls (BMI 34.58 ± 3,86 wt /ht 2 ) and 12 boys (BMI 37.08 ± 3.17 wt /ht 2 ), aged between 15 and 19 years old, was evaluated to leptin, ghrelin and insulin concentrations, visceral adiposity and NAFLD through ultrasonography. The results showed a significant decrease in ghrelin, leptin concentrations and visceral adiposity (p < 0.01). Moreover, a decrease in the NAFLD prevalence was observed. It is an important result, since this disease can progress to cirrhosis, not only in children but also in obese adolescents. This kind of treatment can be efficient to improve metabolic and hormonal profile, as well as, to control obesity and related co-morbidities in obese adolescents.

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Leptin and IGF-I levels in unconditioned male volunteers after short-term exercise

Cited by 52 publications

References 33 publications

Exercise and Circulating Insulin-Like Growth Factor I

Exercise and Circulating Insulin-Like Growth Factor I

Effect of rhIL-6 infusion on GH→IGF-I axis mediators in humans

Tratamento multidisciplinar reduz o tecido adiposo visceral, leptina, grelina e a prevalência de esteatose hepática não alcoólica (NAFLD) em adolescentes obesos

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