2018
DOI: 10.1038/nrn.2018.7
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Leptin and brain–adipose crosstalks

Abstract: Interactions between the brain and distinct adipose depots have a key role in maintaining energy balance, thereby promoting survival in response to metabolic challenges such as cold exposure and starvation. Recently, there has been renewed interest in the specific central neuronal circuits that regulate adipose depots. Here, we review anatomical, genetic and pharmacological studies on the neural regulation of adipose function, including lipolysis, non-shivering thermogenesis, browning and leptin secretion. In … Show more

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Cited by 194 publications
(167 citation statements)
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References 217 publications
(274 reference statements)
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“…Evidence from rodent models has shown that leptin influences the programming of hypothalamic circuits during gestation, which may influence ex utero energy metabolism through satiety and hunger signaling . Additionally, leptin may increase brown adipose tissue deposition and enhance the activity of thermoregulatory circuits, which may in turn influence adipose tissue metabolism and deposition during infancy and childhood .…”
Section: Discussionmentioning
confidence: 99%
“…Evidence from rodent models has shown that leptin influences the programming of hypothalamic circuits during gestation, which may influence ex utero energy metabolism through satiety and hunger signaling . Additionally, leptin may increase brown adipose tissue deposition and enhance the activity of thermoregulatory circuits, which may in turn influence adipose tissue metabolism and deposition during infancy and childhood .…”
Section: Discussionmentioning
confidence: 99%
“…In mice, fasting-induced glycogen shortage activates a liver-brain-adipose neurocircuitry to facilitate fat utilization [61], and the regulation of food intake and glucose homeostasis by liver glycogen is dependent on the hepatic branch of the vagus nerve [62]. In addition, leptin mediated interactions between the brain and adipose depots related to the maintenance of systemic energy balance were recently reviewed [63]. These previous studies provide additional lines of evidence for the existence of our proposed brain-liverfats organ network in the context of STF.…”
Section: A Brain-liver-fats Organ Network Modulated By Stfmentioning
confidence: 99%
“…These neurons respond to an inflow of peripheral signals, arriving from adipose tissue (including leptin and adiponectin), pancreas (insulin), gut hormones (peptide YY, cholecystokinin, glucagon‐like peptide I, and ghrelin), circulating nutrients (glucose and fatty acids), communicating information regarding the energy status of an organism, which is subsequently translated to a specific response. Both orexigenic and anorexigenic neuron types harbor receptors or sensors for circulating hormones and nutrients …”
Section: Introductionmentioning
confidence: 99%