Leptin and Beyond: Actors in Cancer

Barone, Ines; Giordano, Cinzia

doi:10.3390/biom11121836

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…Several interventions to block the development of cachexia would invigorate antitumor immune functions [ 50 , 51 ]. On the other hand, leptin, an adipocyte-derived hormone increased in proportion to total adipose tissue mass, has been shown to involve in both innate and adaptive immune responses [ 52 ]. Recent studies found that it might contribute to the enhancement of the host immune response activated by PD-1/PD-L1 inhibitors in cancer patients [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Nomogram Based on Monocyte-to-Lymphocyte Ratio to Predict Survival of Unresectable Esophageal Squamous Cell Carcinoma Who Receive First-Line PD-1/PD-L1 Inhibitors Combined with Chemotherapy

Ding

Qian

et al. 2022

Current Oncology

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Background. Chemoimmunotherapy has become the first-line treatment for unresectable esophageal squamous cell carcinoma (ESCC). Still, reliable biomarkers to identify patients who could benefit from this combined therapy remain uncertain. This study focused on elucidating the predictive significance of the monocyte-to-lymphocyte ratio (MLR) and establishing the prognostic nomogram for unresectable ESCC treated with chemoimmunotherapy. Methods. Data of clinical features, peripheral blood parameters, and treatment records were collected in unresectable ESCC patients who received PD-1/PD-L1 inhibitors plus chemotherapy as the first-line treatment from September 2017 to August 2021. The nomogram based on MLR and clinical parameters for predicting the overall survival (OS) was developed and validated. Results. Out of 81 patients enrolled, patients with a lower MLR had significantly longer progression-free survival (PFS) and OS than patients with a higher pretreatment MLR (p = 0.0067; p = 0.00069). The OS nomogram integrating MLR, performance status (PS) score, and body mass index (BMI) achieved a C-index of 0.770 (95%CI 0.645–0.896). The area under the ROC curve (AUC) value of the nomogram predicting 12-, 18-, and 24-month OS rates were 0.855, 0.792, and 0.744, respectively, which were higher than the clinical TNM staging system or the MLR. Stratified by the nomogram-generated scores, three risk groups (low, moderate, and high) in survival curves manifested a distinct difference (p < 0.0001). Conclusion. MLR emerged as an independent predictive factor for PFS and OS in treatment-naive unresectable ESCC patients treated with chemoimmunotherapy. The constructed nomogram of MLR and clinical parameters was a reliable model for prognostic estimation.

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Section: Discussionmentioning

confidence: 99%

Nomogram Based on Monocyte-to-Lymphocyte Ratio to Predict Survival of Unresectable Esophageal Squamous Cell Carcinoma Who Receive First-Line PD-1/PD-L1 Inhibitors Combined with Chemotherapy

Ding

Qian

et al. 2022

Current Oncology

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“…In addition to its physiological role in the body, leptin affects cancer development. Recent studies report that elevated leptin levels correlate with an increased risk of certain malignancies, which mainly include renal cell carcinoma [ 101 ], intestinal cancer [ 102 ], pancreatic cancer [ 103 ], breast cancer [ 104 ] and gynecological cancers, including endometrial cancer [ 105 ] and ovarian cancer [ 106 ]. The potential role of leptin in carcinogenesis is shown in Figure 2 .…”

Section: Leptinmentioning

confidence: 99%

The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer

Stępień

Olczyk

Gola

et al. 2023

Cells

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Due to their multidirectional influence, adipocytokines are currently the subject of numerous intensive studies. Significant impact applies to many processes, both physiological and pathological. Moreover, the role of adipocytokines in carcinogenesis seems particularly interesting and not fully understood. For this reason, ongoing research focuses on the role of these compounds in the network of interactions in the tumor microenvironment. Particular attention should be drawn to cancers that remain challenging for modern gynecological oncology—ovarian and endometrial cancer. This paper presents the role of selected adipocytokines, including leptin, adiponectin, visfatin, resistin, apelin, chemerin, omentin and vaspin in cancer, with a particular focus on ovarian and endometrial cancer, and their potential clinical relevance.

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“…Leptin can bind to its receptor (ObR), leading to a leptin/ObR axis involved in hallmark cancer features such as cellular survival, metabolism, angiogenesis, and metastasis. Leptin can also interact with other pathways such as sex hormones, such as oestrogen, and induce inflammation via cytokine production, for example, IL-6, which can lead to further stimulation of cellular signal transduction pathways (Barone and Giordano. 2021).…”

Section: Diet As a Risk Factor For Cancermentioning

confidence: 99%