Leptin and Adiponectin Levels of Asthmatic Iraqi Children in Hilla Province

Nazarmamoori, Afrah Al; Ewadh, Mufeedjalil; E.Alqaysi, Suhayr

doi:10.22159/ajpcr.2017.v10i12.20394

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Our included asthmatic patients were mostly males. Studies found a higher frequency of asthma in males than females [ 66 , 67 ]. Different patterns of lung function abnormalities in males and females existed due to different pattern of lung growth and fat deposition [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Role of adiponectin, resistin and monocyte chemo-attractant protein-1 in overweight/obese asthma phenotype in children

et al. 2023

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Background Asthma is a chronic inflammatory disorder of the airways with diverse overlapping pathologies and phenotypes contributing to a significant heterogeneity in clinical manifestations. Obesity may modify asthma risk, phenotype, and prognosis. A suggested mechanism linking obesity and asthma is through systemic inflammation. Adipokines secreted by adipose tissue were suggested to provide a link between obesity and asthma. Objective To have an understanding for the contribution of adiponectin, resistin and MCP-1 to development of distinct asthma phenotype in overweight/obese children through assessment of their serum level and correlation to pulmonary function tests. Subjects and methods The study included 29 normal weight asthmatics, 23 overweight/obese asthmatic children and 30 controls. All cases were subjected to detailed history taking, thorough examination and pulmonary function tests. Serum adiponectin, resistin, MCP-1 and IgE were assessed to all recruited subjects. Results Adiponectin level was significantly higher in overweight/obese asthmatics (24900 ± 1600 ng/ml) compared to normal weight asthmatics (21700 ± 1700 ng/ml) and control (23000 ± 3200 ng/ml), (p < 0.001 & 0.051 respectively). Normal weight asthmatics had significantly lower adiponectin level than control, (p = 0.039). A significant low level of MCP-1 in overweight/obese asthmatics (149.5 (20—545) ng/L) compared to control (175 (28 -1123.5) ng/L), p = 0.037. No significant difference was found regarding resistin. Normal weight asthmatics had significantly lower FEV1% and FVC% compared to overweight/obese asthmatics (p = 0.036, 0.016 respectively). A significant positive correlation was found between (FEV1%, FVC) and BMI in normal weight asthmatics (P = 0.01, < 0.01 respectively) and a significant negative correlation between PEF and BMI (-0.42, p = 0.05) in obese/overweight asthmatics. Resistin/adiponectin ratio was not affected by sex, degree of asthma severity or level of asthma control in either normal weight or overweight/obese asthmatic. Conclusion This work could suggest that adiponectin may play a role in overweight/obese asthma phenotype where it is possible to have a dual action (pro & anti- inflammatory). It seems that resistin had no role in asthma pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Role of adiponectin, resistin and monocyte chemo-attractant protein-1 in overweight/obese asthma phenotype in children

et al. 2023

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The relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in Babylon City

Behayaa,

Ali,

Mohammed

et al. 2024

MJBL

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Background: Cardiovascular disease (CVD) is one of the reasons of mortality in the world. In the developing world, deaths from CVD have been increasing. Growth differentiation factor 15 (GDF15) is about cachexia, CVD, and a lot of inflammatory diseases. GDF15 is very low in most tissues, except the placenta (in healthy conditions), which expresses GDF15 in high levels. Though in cardiovascular damage, the level of GDF15 may rise, the natural effects of GDF15 may vary according to the stage of the disease. Objective: The objective of the study was the valuation of GDF15 level in the serum of patients with CVD in Babylon City and to check whether there was a link between age, body mass index, lipid profile, insulin resistance, adiponectin and C-reactive protein with GDF15. Materials and Methods: GDF15 was assessed in 80 Iraqi subjects; 40 were diagnosed with CVD and 40 subjects who appear healthy were considered for this study. The age ranged between 41 and 73 years for patients and control was considered for this study. Enzyme-linked immunosorbent assay technique was used for GDF15 estimation. Results: The results suggested that the serum levels of GDF15 and homeostatic model assessment for insulin resistance displayed a non-significant difference among studied groups (P > 0.05), whereas total cholesterol, high-density lipoprotein, triglyceride, adiponectin, and C-reactive protein appeared to have a significant difference among studied groups (P < 0.05). In contrast, the current study observed a non-significant (P > 0.05) association for GDF15 with all the clinical and biochemical parameters measured in this study. Conclusion: The study concluded that among the patients with CVD, the level of GDF15 revealed a non-significant relationship with the disease.

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Leptin and Adiponectin Levels of Asthmatic Iraqi Children in Hilla Province

Cited by 2 publications

References 30 publications

Role of adiponectin, resistin and monocyte chemo-attractant protein-1 in overweight/obese asthma phenotype in children

Role of adiponectin, resistin and monocyte chemo-attractant protein-1 in overweight/obese asthma phenotype in children

The relationship of growth differentiation factor 15 with some biochemical parameters in cardiovascular disease patients in Babylon City

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