Leptin and adiponectin in patients with systemic lupus erythematosus: clinical and laboratory correlations

Barbosa, Vitalina de Souza; Francescantônio, Paulo Luiz Carvalho; Silva, Nílzio Antônio da

doi:10.1016/j.rbre.2014.08.013

Cited by 8 publications

(12 citation statements)

References 26 publications

(51 reference statements)

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“…It has already been confirmed that serum levels of leptin increased significantly in patients with SLE, a finding that has been replicated in many studies from diverse countries, revealing that leptin can be considered as a novel biomarker in predicting the risk of SLE (80)(81)(82)(83). Recently, several possible mechanisms by which leptin modulates the development of SLE have been emphasized.…”

Section: Relationship Between Leptin and Systemic Lupus Erythematosusmentioning

confidence: 77%

“…Nevertheless, the interaction between leptin and other inflammatory cells under SLE condition is not fully understood (87). Additionally, no significant difference was observed between patients with active and those with inactive SLE (80,88,89). Nevertheless, a lower leptin concentration was found with joint inflammation and neurological symptoms during a course of SLE (90).…”

Section: Relationship Between Leptin and Systemic Lupus Erythematosusmentioning

confidence: 99%

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The Important Role of Leptin in Modulating the Risk of Dermatological Diseases

Cheng

Chang

2021

Front. Immunol.

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It is an indisputable fact that obesity is associated with a series of health problems. One important hallmark of obesity is excessive accumulation of lipids in the adipocyte, especially triglyceride (TG). Currently, the adipocyte has been considered not only as a huge repository of excess energy in the form of fat but also as an important source of multiple hormones and cytokines called adipokines. In obesity, the adipocyte is dysfunctional with excessive production and secretion of pro-inflammatory adipokines, such as tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), and leptin. On the other hand, accumulating evidence has shown that leptin plays a vital role in stimulating angiogenesis, controlling lipid metabolism, and modulating the production of pro-inflammatory cytokines. Furthermore, the various activities of leptin are related to the wide distribution of leptin receptors. Notably, it has been reported that enhanced leptin levels and dysfunction of the leptin signaling pathway can influence diverse skin diseases. Recently, several studies revealed the roles of leptin in wound healing, the hair cycle, and the pathogenic development of skin diseases, such as psoriasis, lupus erythematosus, and dermatological cancers. However, the exact mechanisms of leptin in modulating the dermatological diseases are still under investigation. Therefore, in the present review, we summarized the regulatory roles of leptin in the pathological progression of diverse diseases of skin and skin appendages. Furthermore, we also provided evidence to elucidate the complicated relationship between leptin and different dermatological diseases, such as systemic lupus erythematosus (SLE), psoriasis, hidradenitis suppurativa, and some skin tumors.

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Section: Relationship Between Leptin and Systemic Lupus Erythematosusmentioning

confidence: 77%

Section: Relationship Between Leptin and Systemic Lupus Erythematosusmentioning

confidence: 99%

The Important Role of Leptin in Modulating the Risk of Dermatological Diseases

Cheng

Chang

2021

Front. Immunol.

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“…Many studies showed that adiponectin was high in RA patients (17,18) and others (19,20) showed that adiponectin was high in SLE than control. On the other hand, Barbosa et al (21) , concluded that the level of adiponectin was not high in SLE patients. Another study reported that the mean adiponectin level was significantly lower in SLE patients compared to control (22) .…”

Section: Discussionmentioning

confidence: 96%

Serum Adiponectin and Insulin Resistance in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients

Elgendy¹,

Salman

2023

The Egyptian Journal of Hospital Medicine

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Background: Insulin sensitivity, blood sugar, lipids, and cardiovascular disease (CVD) are all affected by adiponectin. Adiponectin's involvement in the aetiology of autoimmune illness is still debatable. Objective: To assess the blood level of adiponectin in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), as well as the probable relationship with insulin resistance and disease activity ratings. Patients and methods: A total of 100 SLE, 100 RA, and 100 matched controls were examined. Both the disease activity score (DAS28) and the SLE disease activity index (SLEDAI) were evaluated. Serum adiponectin, C-peptide, and lipid profile were all measured. Both the homeostasis assessment model of insulin resistance (HOMA-IR) and HOMA-B homeostasis model evaluation indices for beta cell function were evaluated. Results: In SLE and RA patients, adiponectin (12.27±1.45, 12.05±0.94 vs 4.12±2.03), C peptide (3.97±2.85, 5.66±3.69 vs 1.8±0.9), fasting insulin levels (37.6±13.2, 35.85±13.68 vs 6.55±2.04), HOMR-IR (7.9±3.03, 7.1±3.09 vs 1.33±0.67) were significantly higher compared to control group (p<0.001). In patients with SLE and RA, adiponectin had significant positive correlation with ESR and disease activity (p<0.001, p=0.042 and p<0.001, p=0.015 respectively) but negative correlation with platelet count (p=0.003, p=0.004), while C-peptide had significant positive correlation with HOMA-B (p= 0.019, 0.041), ESR (p=0.004, p<0.001), and BMI (p=0.020, p<0.001) Conclusion: Adiponectin level, C-peptide and indices of IR are elevated in patients with SLE and RA. Adiponectin positively correlated with disease activity and ESR and C-peptide positively correlated with HOMA-B in SLE and RA patients.

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“…Однако у больных СКВ убедительных доказательств наличия связи между уровнем лептина и активностью или клиническими проявлениями заболевания до настоящего времени не получено [3, 4], а имеющиеся данные противоречивы. Так, в одной из работ выявлена ассоциация между большей концентрацией лептина и поражением почек [15], тогда как в другой зависимости протеинурии от АЦК не обнаружено [16]. D. Chougule и соавт.…”

Section: Introductionunclassified

“…[18], наоборот, выявили более низкий уровень лептина при поражении суставов и центральной нервной системы. Отсутствие связи между концентрацией лептина и активностью СКВ продемонстрировано в нескольких исследовани-ях [5,15,[19][20][21], наряду с этим М. Vadacca и соавт. [22] сообщили о прямой, а D. Chougule и соавт.…”

Section: Introductionunclassified

Clinical significance of leptin in systemic lupus erythematosus

Kondratyeva¹,

Panafidina²,

Попкова³

et al. 2021

Sovremennaâ revmatologiâ

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Objective: to study the frequency of hyperleptinemia in patients with systemic lupus erythematosus (SLE), its relationship with clinical and laboratory manifestations of the disease, drug therapy, and other metabolic disorders.Patients and methods. The cross-sectional study included 46 women with a definite diagnosis of SLE (median age 40 [31; 48] years) and disease duration 3.0 [0.9; 9.0] years. Glucocorticoids (GC) were received by 38 (83%) patients, hydroxychloroquine – by 35 (76%), immunosuppressants – by 10 (22%), biologic disease-modifying antirheumatic drugs – by 5 (11%). In all patients, fasting levels of glucose, leptin, apoliproprotein B (ApoB) and immunoreactive insulin were determined, and homeostatic model assessment for insulin resistance (HOMA-IR) was calculated. Concentration of leptin ≥11.1 ng/ml, ApoB – >1.6 mg/ml were considered an elevated level. HOMA-IR index ≥2.77 corresponded to the presence of insulin resistance (IR).Results and discussion. Hyperleptinemia was found in 34 (74%) patients with SLE, an increased level of ApoB – in 19 (41%), IR – in 10 (22%). In patients with hyperleptinemia, serositis, positivity for anti-double-stranded DNA (aDNA) and hypocomplementemia were less common, overweight and obesity were more frequent, the SLEDAI-2K index was lower, the aDNA level was lower, and the concentration of the C3 component of complement, insulin, HOMA-IR index, body mass index (BMI) and disease duration were higher (p<0.05 for all cases). BMI <25 kg / m2 had 26 (57%) women, 14 (54%) of whom had hyperleptinemia. In patients with BMI <25 kg / m2, we found a relationship between leptin concentration and disease duration (r=0.4, p=0.04), SLE activity according to SLEDAI-2K (r=-0.6, p=0.003), levels of aDNA (r=-0.6, p<0.001), C3 component of complement (r=0.5, p=0.01), maximum (r=0.7, p<0.001) and supporting (r=0,5, p=0.023) GC doses.In patients with BMI ≥25 kg/m2 (n=20), no such relationship was observed.Conclusion. Hyperleptinemia was found in the majority of women with SLE; elevated levels of ApoB and IR were much less common. Patients with hyperleptinemia are characterized by a longer duration and less activity of the disease, as well as the presence of overweight and obesity and an increase in the HOMA-IR index. In SLE patients with normal body weight, the concentration of leptin increased along with GC dose elevation.

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Leptin and adiponectin in patients with systemic lupus erythematosus: clinical and laboratory correlations

Cited by 8 publications

References 26 publications

The Important Role of Leptin in Modulating the Risk of Dermatological Diseases

The Important Role of Leptin in Modulating the Risk of Dermatological Diseases

Serum Adiponectin and Insulin Resistance in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients

Clinical significance of leptin in systemic lupus erythematosus

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