Leptin, adiponectin, and asthma: findings from a population-based cohort study

Sutherland, Tim; Sears, Malcolm R.; McLachlan, Christene R.; Poulton, Richie; Hancox, Robert J.

doi:10.1016/s1081-1206(10)60161-5

Cited by 66 publications

(70 citation statements)

References 36 publications

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“…This may explain why our results may differ from previous negative studies in the field (32)(33)(34). Further, we demonstrate a greater asthma risk due to lower serum adiponectin concentrations among women who currently smoke than women who do not currently smoke, but the mechanistic basis for this interaction is not currently known.…”

Section: Discussioncontrasting

confidence: 80%

“…The literature pertaining to the adiponectin-asthma association is conflicting and confusing. Five human studies have analyzed the association between serum adiponectin and odds of prevalent asthma, independent of obesity (6,(31)(32)(33)(34), of which three studies show no significant associations (32)(33)(34) (Table E3). These studies are limited by their smaller numbers of girls/women, modest effect sizes, and lower prevalence of asthma and obesity in populations outside the United States (32-34).…”

Section: Discussionmentioning

confidence: 99%

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Low Serum Adiponectin Predicts Future Risk for Asthma in Women

Sood¹,

Qualls

Schuyler³

et al. 2012

Am J Respir Crit Care Med

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Rationale: Our previous cross-sectional study showed that serum adiponectin is inversely associated with asthma among women. However, it is not known if serum adiponectin predicts future development of asthma or if asthma affects subsequent serum adiponectin concentrations among women. Objectives: To determine longitudinal association between serum adiponectin and incident asthma among women. Methods: We used data from examinations at Years 10, 15, and 20 of the Coronary Artery Risk Development in Young Adults (CARDIA) cohort. In our primary analysis, the association of CARDIA Year 15 serum adiponectin concentration with Year 20 incident asthma was evaluated. In our secondary analysis, the converse direction, that is, the association of CARDIA Year 10 prevalent asthma with Year 15 serum adiponectin, was evaluated, using logistic regression techniques. Measurements and Main Results: Our primary analysis included 1,450 women, mostly premenopausal. Multivariable analyses demonstrated that the lowest tertile of Year 15 serum adiponectin concentration (,7 mg/L) predicted significantly higher risk for incident asthma at Year 20 among women (odds ratio, 2.07; 95% confidence interval, 1.05, 4.10), and particularly among current smokers (interaction P ¼ 0.051). Further, low serum adiponectin was more important than body mass index in predicting the risk for incident asthma among women. We also showed that the converse relationship was not true; that is, Year 10 prevalent asthma did not predict Year 15 serum adiponectin concentrations in women. Conclusions: Serum adiponectin affects future risk for asthma in women and not vice versa. Measures that raise systemic adiponectin concentrations may lead to newer ways to prevent asthma among women, particularly among those who smoke.Keywords: incident asthma; obesity; adiponectin; adipokine; women In 2005, more than 21 million people in the United States were estimated to be affected by asthma, amounting to 7.6% of the total population (1). Between 1980 and 1996, the prevalence of, and morbidity trends related to, asthma increased in the United States (2, 3). It is now well established that asthma is related to adiposity, particularly among women. Adipokines, proteins produced by adipose tissue, may regulate systemic inflammation and play a role in asthma (4-7). Adiponectin is one such adipokine with predominantly antiinflammatory effects. Adiponectin inhibits proinflammatory cytokines and endothelial adhesion molecules and induces antiinflammatory cytokines (8-11). Further, adiponectin regulates the proliferation and function of inflammatory cells including NK cells and T lymphocytes (12, 13).Although visceral adipocytes are the most important source of adiponectin, serum adiponectin concentrations are reduced in obese subjects (14,15). One possible explanation is that hypoxia-related necrosis of adipocytes activates macrophages in obese subjects (16). These activated macrophages produce tumor necrosis factor-a and IL-6, which in turn may directly inhibit the local production o...

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Section: Discussioncontrasting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Low Serum Adiponectin Predicts Future Risk for Asthma in Women

Sood¹,

Qualls

Schuyler³

et al. 2012

Am J Respir Crit Care Med

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“…BRUNO et al [20] observed a differential expression of leptin in both the submucosa and epithelial cells in the airways of people with chronic obstructive pulmonary disease (COPD) compared with both healthy controls and smokers, while COPD severity was associated with the presence of these leptin-positive cells. The importance of leptin is still being investigated in asthma; a relationship between circulating leptin levels and risk of asthma development was observed in females in one study [21], while another cited no relationship [22]. We observed only a very small difference in sputum IL-8 between obese and nonobese asthmatic females, which is unlikely to be relevant, suggesting another mediator is responsible for the association between sputum neutrophils and BMI.…”

mentioning

confidence: 49%

Airway inflammation is augmented by obesity and fatty acids in asthma

Scott¹,

Gibson²,

Garg³

et al. 2011

European Respiratory Journal

273

242

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Obesity and asthma are associated, but the mechanism(s) of the association have yet to be elucidated. The aim of this study was to assess airway inflammation in relation to obesity and plasma fatty acids in males and females with and without asthma.Obese (n568) and nonobese (n547) adults with asthma, and obese (n516) and nonobese (n563) healthy controls had induced sputum and venous blood samples analysed for inflammatory markers.There was a positive interaction between obesity and asthma on sputum neutrophil percentage (p50.012) and C-reactive protein level (p50.003). Although sputum eosinophil percentage was elevated in asthma (p50.001), there was no effect of obesity (p50.16). Sputum neutrophil percentage was positively associated with body mass index in females with asthma (b51.015, 95% CI 0.258-1.772; p50.009) and neutrophilic asthma was present in a greater proportion of obese compared with non-obese females (42.9% versus 16.2%; p50.017). In males with asthma, sputum neutrophil percentage was positively associated with total plasma saturated fatty acids (b50.108, 95% CI 0.036-0.180; p50.004) and negatively with monounsaturated fatty acids (b5 -0.068, 95% CI -0.131--0.005; p50.035).This was the first study to demonstrate an increase in neutrophilic airway inflammation in obese asthma. This relationship was significant only in females with asthma. In males, saturated and monounsaturated fatty acids were important predictors of neutrophilic airway inflammation in asthma.

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“…Various results from different studies, sometimes in great conflict with each other, were reported. One of these studies, performed by Sutherland et al, demonstrated that leptin was unlikely to mediate the association between asthma and obesity (22).…”

Section: Discussionmentioning

confidence: 99%

The Serum Level of Leptin in Patients with Obesity: Asthmatic and Non-Asthmatic Children

et al. 2017

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Background: Leptin is a pro-inflammatory cytokine produced by adipose tissue. Considering the association between obesity and asthma, the current study aimed at investigating if leptin was in the pathway of obesity-asthma relationship in children and if it played a distinctive role in children with asthma and obesity versus the ones with obesity but without asthma. Methods: The current case-control study was conducted on 23 children with asthma and obesity and 13 children with obesity but

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Leptin, adiponectin, and asthma: findings from a population-based cohort study

Cited by 66 publications

References 36 publications

Low Serum Adiponectin Predicts Future Risk for Asthma in Women

Low Serum Adiponectin Predicts Future Risk for Asthma in Women

Airway inflammation is augmented by obesity and fatty acids in asthma

The Serum Level of Leptin in Patients with Obesity: Asthmatic and Non-Asthmatic Children

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