LEPTIN A19G POLYMORPHISM AND LEPTIN RECEPTOR Gln223Arg AND Lys109Arg POLYMORPHISMSIN POSTMENOPAUSAL OSTEOPOROSIS

Abstract

Objective: to study an association of leptin (LEP) A19G polymorphism and leptin receptor (LEPR) Gln223Arg AND Lys109Arg polymorphisms with the predilection for postmenopausal osteoporosis (OP). Subjects and methods. PCR analysis was used to examine the polymorphisms among 428 women (254 patients with OP and 174 healthy women).The anthropometric, densitometric, and biochemical markers of bone remodeling and standard clinical and biochemical parameters were studied. Results. Statistically significant differences were found in the distribution of the genotypes of LEP A19G polymorphism between the women with OP and the controls (χ 2 = 9.41; p = 0.009). In the patients with OP, the 19GG genotype frequency was significantly higher than that in the controls [OR = 2.0;

Mendelian Randomization Analysis Identifies Inverse Causal Relationship between External Eating and Metabolic Phenotypes

“…Whole venous blood samples were obtained from each participant, stored at −4 °C, and used for total DNA extraction. DNA extraction and genotyping were performed using standard procedures as previously described [ 29 , 30 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. Genetic variants were selected for the analysis based on the results of the Phenome-Wide Association Studies (PheWASs).…”

Integrating Common Risk Factors with Polygenic Scores Improves the Prediction of Type 2 Diabetes

“…Whole venous blood samples were obtained from each participant, stored at −4 °C, and used for total DNA extraction. DNA extraction and genotyping procedures were performed as previously described [ 68 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ]. Genetic variants for the analysis were selected based on the previously detected associations with diabetes and related traits ( Supplementary Table S3 ), the results of the Phenome-Wide Association Studies (PheWAS), and the variants selected for the study included those associated with metabolic traits (cholesterol levels, fat mass, T2D) and related disorders including inflammatory diseases and complications caused by T2D ( Supplementary Table S4 ).…”

Genetic Aspects of Panniculitis in a Russian Population: A Pilot Study

“…Наблюдались достоверные различия таких показателей, как возраст и длительность з а б о л е в а н и я . О р и г и н а л ь н ы е и с с л е д о в а н и я Повышенная частота генотипа 19GG гена LEP была обнаружена нами у женщин с постменопаузальным остеопорозом [9]. Пациентки с GG-генотипом имели средний показатель минеральной плотности кости шейки бедра на 4% ниже, чем у носителей генотипа АА.…”