Leprosy in the 21st Century

White, Cameron; Franco‐Paredes, Carlos

doi:10.1128/cmr.00079-13

Cited by 188 publications

(215 citation statements)

References 83 publications

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“…White and Franco-Paredes [21] observed that 35.74% of leprosy patients consume alcoholic beverages and 36.99% smoke. Similar results were obtained in the present study.…”

Section: Discussionmentioning

confidence: 99%

Correlation between therapy and lipid profile of leprosy patients: is there a higher risk for developing cardiovascular diseases after treatment?

et al. 2017

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BackgroundThe impact of leprosy reduces health-related quality of life of affected patients, interfering with different factors such as nutrition. This study investigated the lipid profile, nutritional status, and risk for cardiovascular disease (CVD) in patients who underwent leprosy treatment in Brazil.MethodsEighty-four adult patients of both genders ranging in age from 20 to 60 years and diagnosed with paucibacillary (PB) or multibacillary (MB) leprosy were selected after undergoing multidrug treatment. The following data were collected: sociodemographic and clinical data; food intake; anthropometric measures (weight, height, and waist circumference); and lipid profile components (total cholesterol, high-density lipoprotein cholesterol [HDL-c], low-density lipoprotein cholesterol [LDL-c], and triglycerides).ResultsAmong the study population, there was a predominance of males (65.48%) aged 50 to 60 years, patients with an income of 248–496 American dollars (63.10%), patients who completed elementary school (65.48%), inactive patients (76.19%), non-smokers (46.43%), and non-drinking patients (69.05%). The levels (mean ± standard deviation) of total cholesterol were 193.8 ± 29.4 mg/dL in the PB form and 203.5 ± 41.7 mg/dL in the MB form. The mean LDL-c was 116.9 ± 22.7 mg/dL in PB patients and 121 ± 31.3 mg/dL in MB patients. Mean triglyceride levels were 123.4 ± 45.2 mg/dL in the PB form and 147.4 ± 88.9 mg/dL in the MB form. The evaluation of nutritional status showed that 41.67% of the patients were eutrophic, while 55.96% had excess weight. Food intake was significantly associated with HDL-c in male patients (P = 0.0264) and with triglycerides in patients above the ideal weight (P = 0.0049).ConclusionsThe risk of acquiring CVDs was observed to be high due to patients’ excess weight and increased waist circumference. This study will guide clinicians in the adequate treatment of patients with leprosy in order to avoid adverse cardiovascular events.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-017-0295-1) contains supplementary material, which is available to authorized users.

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“…White and Franco-Paredes [21] observed that 35.74% of leprosy patients consume alcoholic beverages and 36.99% smoke. Similar results were obtained in the present study.…”

Section: Discussionmentioning

confidence: 99%

Correlation between therapy and lipid profile of leprosy patients: is there a higher risk for developing cardiovascular diseases after treatment?

et al. 2017

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“…Hansen's disease is an infectious disease caused by the intracellular bacillus Mycobacterium leprae, which main clinical manifestations are dermato-neurological lesions that lead to the appearance of physical and psychosocial limitations (1).…”

Section: Introductionmentioning

confidence: 99%

Fatores influenciadores do conhecimento dos estudantes de enfermagem sobre hanseníase: estudo transversal

Garcês

Neto²,

Silva

et al. 2017

Online braz j nurs

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Aim: to identify the factors that influence Nursing students' knowledge about Hansen's disease. Method: this is a cross-section study with a quantitative approach, performed from May to June 2016. The sample was composed by 167 Nursing students of a public university located in the Northeastern region of Brazil. Result: the majority of students knows the main aspects of the disease. Factors such as being single, not having another occupation or income, to live with few other people, and search for information with professor were associated to a higher level of understanding about leprosy. Female students demonstrated less chances to know about Hansen's disease. Conclusion: Nursing students know about leprosy, however there are still questions regarding the transmission of the illness.

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“…Leprosy is caused by the bacteria, Mycobacterium leprae, and infects skin, nerves, and mucous membranes with the potential to cause significant nerve damage and disability. 3 In terms of presentation, leprosy involves a pathologic disease spectrum, with indeterminate and tuberculoid cases on one end of the spectrum and lepromatous disease on the opposite end (Table 1). Transmission is believed to occur through nasal droplets of untreated patients, 4 but there is also evidence it could spread through direct contact.…”

Section: Introductionmentioning

confidence: 99%

Complex Type 2 Reactions in Three Patients with Hansen's Disease from a Southern United States Clinic

Leon

Salinas

McDonald

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Abstract. In non-endemic countries, leprosy, or Hansen's disease (HD), remains rare and is often underrecognized. Consequently, the literature is currently lacking in clinical descriptions of leprosy complications in the United States. Immune-mediated inflammatory states known as reactions are common complications of HD. Type 1 reactions are typical of borderline cases and occur in 30% of patients and present as swelling and inflammation of existing skin lesions, neuritis, and nerve dysfunction. Type 2 reactions are systemic events that occur at the lepromatous end of the disease spectrum, and typical symptoms include fever, arthralgias, neuritis, and classic painful erythematous skin nodules known as erythema nodosum leprosum. We report three patients with lepromatous leprosy seen at a U.S. HD clinic with complicated type 2 reactions. The differences in presentations and clinical courses highlight the complexity of the disease and the need for increased awareness of unique manifestations of lepromatous leprosy in non-endemic areas.

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Leprosy in the 21st Century

Cited by 188 publications

References 83 publications

Correlation between therapy and lipid profile of leprosy patients: is there a higher risk for developing cardiovascular diseases after treatment?

Correlation between therapy and lipid profile of leprosy patients: is there a higher risk for developing cardiovascular diseases after treatment?

Fatores influenciadores do conhecimento dos estudantes de enfermagem sobre hanseníase: estudo transversal

Complex Type 2 Reactions in Three Patients with Hansen's Disease from a Southern United States Clinic

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