Leonurine, a potential drug for the treatment of cardiovascular system and central nervous system diseases

Huang, Lu; Xu, Ding‐Qiao; Chen, Yanyan; Yue, Shi‐Jun; Tang, Yuping

doi:10.1002/brb3.1995

Cited by 28 publications

(19 citation statements)

References 57 publications

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“…Numerous in vivo and in vitro experimental studies have confirmed the antiplatelet activity of PBCRBSCMs and their interaction with antiplatelet drugs. PBCRBSCMs and their active ingredients and antiplatelet drugs are widely used in the clinical treatment of coronary heart diseases [ 73 , 74 ]. A study comprising 16,856 patients in 37 first-class tertiary hospitals in China showed that the frequency of combined use of Suxiao Jiuxin Pill and aspirin was as high as 50.77%.…”

Section: The Mechanisms Of Pbcrbscm Combined With Antiplatelet Drugs In Ischemic Heart Diseasementioning

confidence: 99%

Combined Therapy with Traditional Chinese Medicine and Antiplatelet Drugs for Ischemic Heart Disease: Mechanism, Efficacy, and Safety

Zhang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Ischemic heart disease is a significant risk factor that threatens human health, and antiplatelet drugs are routinely used to treat cases in clinical settings. Chinese medicine for promoting blood circulation and removing blood stasis (PBCRBSCM) can often be combined with antiplatelet drugs to treat ischemic heart disease. PBCRBSCM can inhibit platelet adhesion, activation, and aggregation; moreover, PBCRBSCM in combination with antiplatelet drugs exerts antiplatelet effects. The mechanism is related to several factors, including the inhibition of platelet activation and aggregation, improvement of the hemodynamic status and coagulation function, and correction of metabolism and inflammation. PBCRBSCM can also regulate the absorption and metabolism of conventional antiplatelet drugs and protect the gastric mucosal epithelial cells against damage induced by conventional antiplatelet drugs. Randomized controlled trials have confirmed that PBCRBSCM preparations and the active ingredients in these preparations can reduce resistance to aspirin and clopidogrel so that the combination of these drugs can exert their antiplatelet effects. In the perioperative treatment of patients with stable angina pectoris, unstable angina pectoris, and acute coronary syndrome undergoing percutaneous coronary intervention therapy, preparations of the active ingredients of PBCRBSCM combined with antiplatelet drugs and other conventional Western medicine treatments have been proven effective. The efficacy and safety of such combinations have also been extensively verified. Considerable progress has been made to understand the antiplatelet mechanism of PBCRBSCM. However, most clinical studies had problems, such as limited sample size and inappropriate research design, which has limited the translational use of PBCRBSCM in antiplatelet therapy. A large-scale, multicenter, randomized controlled study with cardiovascular events as the endpoint is still to be conducted to provide evidence for the combined application of PBCRBSCM and antiplatelet drugs in the prevention and treatment of ischemic heart disease.

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Section: The Mechanisms Of Pbcrbscm Combined With Antiplatelet Drugs In Ischemic Heart Diseasementioning

confidence: 99%

Combined Therapy with Traditional Chinese Medicine and Antiplatelet Drugs for Ischemic Heart Disease: Mechanism, Efficacy, and Safety

Zhang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Leonurine (LEO) is a special alkaloid, which is found in Chinese motherwort (Leonurus japonicus Houtt). Numerous studies have shown that LEO exerts multiple biologic effects, including protective effects on ischemic myocardium and brain, 10,11) antioxidative, 12) and anti-inflammatory. 13) Song et al reported that LEO has an anti-inflammatory effect by inhibiting the expression of the TLR4 pathway in mammary glands of mice mastitis model.…”

Section: Introductionmentioning

confidence: 99%

Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway

Han¹,

Chen²,

Liu³

et al. 2022

CHEMICAL & PHARMACEUTICAL BULLETIN

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Despite the precise mechanisms for renal ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) are poorly understood, nuclear factor erythroid 2 related factor 2 (Nrf2) and Toll-like receptor 4 (TLR4) pathways were considered as the important targets. Leonurine (LEO) is a special alkaloid extracted from Chinese motherwort (Leonurus japonicus Houtt), which has an anti-inflammatory effect and reduces oxidative stress. We conducted the study to explore the efficacy of LEO against I/R-induced AKI in rats and further investigated the underlying mechanisms. Ischemic renal injury was induced by temporary vascular clamping for 45 min. We have measured the levels of inflammation-related biomarkers and antioxidative stress markers. Next, Western blot analysis and Real-time PCR were performed to analyze whether the Nrf2 and TLR4/nuclear factor-kappaB (NF-κB) pathways were involved in this process. We found that LEO pretreatment remarkably decreased serum creatinine and blood urea nitrogen (BUN) in I/R rats and attenuated acute tubular damage. In addition, LEO markedly increased the expression of antioxidant proteins and decreased the levels of inflammatory factors. Further study revealed that LEO promoted Nrf2 into the nucleus, promoted the expression of heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO-1), and suppressed the TLR4/NF-κB signal pathway in kidney tissues of ischemic AKI rats. The study reveals that LEO has a protective effect to prevent ischemic AKI through activation of Nrf2 nuclear translocation resisting oxidative stress injury and inhibition of the TLR4/NF-κB pathway mediated inflammatory gene expression.

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“…By modifying the structure of LEO, the shortcomings regarding the low bioavailability, weak transmembrane ability, and poor fat solubility of LEO have been solved [ 13 ]. Previous studies have shown that LEO has a protective effect on the cardiovascular system, such as providing protection against hypoxia-induced myocyte cell death and myocardial infarction, attenuating myocardial fibrosis and preventing atherosclerosis [ 14 ]. Importantly, LEO has been proven to have anti-inflammatory and antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Leonurine Attenuates Obesity-Related Vascular Dysfunction and Inflammation

Shi

Zhang

et al. 2022

Antioxidants

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Oxidative stress in adipose tissue is a crucial pathogenic mechanism of obesity-associated cardiovascular diseases. Chronic low-grade inflammation caused by obesity increases ROS production and dysregulation of adipocytokines. Leonurine (LEO) is an active alkaloid extracted from Herba Leonuri and plays a protective role in the cardiovascular system. The present study tested whether LEO alleviates inflammation and oxidative stress, and improves vascular function in an obese mouse model. Here, we found that obesity leads to inflammation and oxidative stress in epididymal white adipose tissue (EWAT), as well as vascular dysfunction. LEO significantly improved inflammation and oxidative stress both in vivo and in vitro. Obesity-induced vascular dysfunction was also improved by LEO as evidenced by the ameliorated vascular tone and decreased mesenteric artery fibrosis. Using mass spectrometry, we identified YTHDF1 as the direct target of LEO. Taken together, we demonstrated that LEO improves oxidative stress and vascular remodeling induced by obesity and targets YTHDF1, raising the possibility of LEO treating other obesity-related metabolic syndromes.

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Leonurine, a potential drug for the treatment of cardiovascular system and central nervous system diseases

Cited by 28 publications

References 57 publications

Combined Therapy with Traditional Chinese Medicine and Antiplatelet Drugs for Ischemic Heart Disease: Mechanism, Efficacy, and Safety

Combined Therapy with Traditional Chinese Medicine and Antiplatelet Drugs for Ischemic Heart Disease: Mechanism, Efficacy, and Safety

Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway

Leonurine Attenuates Obesity-Related Vascular Dysfunction and Inflammation

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