Leontiasis ossea

Medical management of sensorineural hearing loss PART II: Musculo-skeletal system

“…The term Leontiasis was originally applied to describe the facial changes and distortion in leprosy. Later Virchow suggested the term Leontiasis Ossea to describe certain cases of hyperostosis of the skull (Knaggs, 1924). More recently it has been realized that under this descriptive term referring to enlargement of facial bones, most cases that have been reported are due to some recognized diseased entity, most commonly fibrous displasia and Paget's disease of bone (Byers and Jones, 1969).…”

Dramatic Alteration of the Skull in a Uremic Patient with Leontiasis Ossea

“…The effects of these altered metabolic levels on a range of musculoskeletal manifestations are referred to as renal osteodystrophy. At the extreme of this range is a complication of chronic renal failure (CRF) known as uremic leontiasis ossea (ULO) that clinically presents with macrognathia and severe facial deformities (5,6).…”

“…The term leontiasis was initially used to describe changes in the facial skin observed in patients with leprosy. Such chronic indurative cutaneous changes, as opposed to bony overgrowth, induce a lion-like facial expression (7)(8)(9). Al- ration of the skull achieved using radiological measurements exacerbates the lack of knowledge regarding ULO.…”