Leonor Ruiz Gurillo and M. Belén Alvarado Ortega: Irony and Humor:From Pragmatics to Discourse

Ruiz-Moneva, María Ángeles

doi:10.1515/humor-2015-0138

Cited by 4 publications

(7 citation statements)

References 2 publications

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“…These observations provide strong evidence for a potential beneficial effect of AT2 receptor signalling in the heart and lungs (Adachi et al, 2003;Imai et al, 2005). In fact, the AT2 receptor is known to oppose many of the detrimental actions of the AT1 receptor, resulting in vasodilation, cell differentiation, reduced proliferation, apoptosis, decreased inflammation and diminished fibrosis (Yamada et al, 1996;Ruiz-Ortega et al, 2001;Zhao et al, 2003;Yayama et al, 2006;Jiang et al, 2007;Rompe et al, 2010). These AT2 receptor-mediated effects are important considerations in These Tables list key protein targets and ligands in this article which are hyperlinked to corresponding entries in http:// www.guidetopharmacology.org, the common portal for data from the IUPHAR/BPS Guide to PHARMACOLOGY (Pawson et al, 2014) and are permanently archived in the Concise Guideto PHARMACOLOGY 2013/14 ( a,b Alexander et al, 2013a.…”

Section: Introductionmentioning

confidence: 94%

Selective activation of angiotensin AT₂ receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis

Bruce

Shenoy

Rathinasabapathy

et al. 2015

British J Pharmacology

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Background and Purpose Pulmonary hypertension (PH) is a devastating disease characterized by increased pulmonary arterial pressure, which progressively leads to right‐heart failure and death. A dys‐regulated renin angiotensin system (RAS) has been implicated in the development and progression of PH. However, the role of the angiotensin AT2 receptor in PH has not been fully elucidated. We have taken advantage of a recently identified non‐peptide AT2 receptor agonist, Compound 21 (C21), to investigate its effects on the well‐established monocrotaline (MCT) rat model of PH. Experimental Approach A single s.c. injection of MCT (50 mg·kg−1) was used to induce PH in 8‐week‐old male Sprague Dawley rats. After 2 weeks of MCT administration, a subset of animals began receiving either 0.03 mg·kg−1 C21, 3 mg·kg−1 PD‐123319 or 0.5 mg·kg−1 A779 for an additional 2 weeks, after which right ventricular haemodynamic parameters were measured and tissues were collected for gene expression and histological analyses. Key Results Initiation of C21 treatment significantly attenuated much of the pathophysiology associated with MCT‐induced PH. Most notably, C21 reversed pulmonary fibrosis and prevented right ventricular fibrosis. These beneficial effects were associated with improvement in right heart function, decreased pulmonary vessel wall thickness, reduced pro‐inflammatory cytokines and favourable modulation of the lung RAS. Conversely, co‐administration of the AT2 receptor antagonist, PD‐123319, or the Mas antagonist, A779, abolished the protective actions of C21. Conclusions and Implications Taken together, our results suggest that the AT2 receptor agonist, C21, may hold promise for patients with PH.

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Section: Introductionmentioning

confidence: 94%

Selective activation of angiotensin AT₂ receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis

Bruce

Shenoy

Rathinasabapathy

et al. 2015

British J Pharmacology

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“…It has been well established that activation of local reninangiotensin system (RAS) within the kidney plays an important role in the pathogenesis of many renal diseases. Ang II has been considered as a true cytokine with an active role in renal pathology [1][2][3]. It modulates cell growth and extracellular matrix (ECM) synthesis and degradation [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…Ang II has been considered as a true cytokine with an active role in renal pathology [1][2][3]. It modulates cell growth and extracellular matrix (ECM) synthesis and degradation [1][2][3][4]. One common feature of progressive renal disease is the proliferation of resident renal cells, accumulation of ECM, and tissue retraction [5].…”

Section: Introductionmentioning

confidence: 99%

Adiponectin attenuates Ang Ⅱ‐induced TGFβ1 production in human mesangial cells via an AMPK‐dependent pathway

Tan

Tang

Rui

2015

Biotech and App Biochem

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Glomerulosclerosis is a key element in end-stage renal failure. Angiotensin II (Ang II) plays an important role in modulating cell growth and extracellular matrix (ECM) synthesis and degradation. Adiponectin, a protein derived from adipocytes, is primarily involved in regulating glucose levels and fatty acid break down. It has recently been shown to have antiatherosclerotic and anti-inflammatory properties. However, the role of adiponectin as a renoprotective agent has not been fully explored. We herein examine the effect of adiponectin on Ang II-induced TGFβ1 and ECM production in human renal mesangial cells (HRMCs) and explore the signaling pathway involved. In this study, we found that both adiponectin receptor 1 and adiponectin receptor 2 are expressed in HRMCs. Adiponectin (10 μg/mL) attenuated the stimulatory effect of Ang II on TGF-β1 and fibronectin. Furthermore, adiponectin activated the AMP-activated protein kinase (AMPK), and the AMPK-specific inhibitor (compound C) blocked AMPK activation. We also determined that compound C blocked the inhibitory effect of adiponectin on Ang II-stimulated TGFβ1 and fibronectin production. In summary, these results demonstrate that adiponectin suppresses Ang II-induced synthesis of ECM in mesangial cells via activation of the AMPK pathway. Based on our data, we suggest that this mechanism could delay the progression of kidney disease.

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“…Além desses efeitos, tem sido descrita em anos recentes a participação do sistema renina-angiotensina (SRA) na resposta imunológica e inflamatória. A AII está envolvida, provavelmente através do receptor AT1, em vários aspectos do processo inflamatório [5,6], regulando a expressão de várias substâncias bioativas, tais como fatores de crescimento [7] e citocinas [2,8]. O tratamento com antagonistas do receptor AT1 (bRAT), e com inibidores da enzima conversora de angiotensina (iECA), apresentou um efeito anti-hipertensivo, anti-proteinúrico e renoprotetor em pacientes com nefropatia diabética, protegendo contra a progressão da nefropatia, adiando a necessidade de diálise ou transplante [3,[9][10][11].…”

Section: Introductionunclassified

“…Com a perpetuação do insulto, a inflamação, a esclerose glomerular e a fibrose do tecido renal progridem até que haja perda total da função renal. Há ainda outras alterações observadas nesse modelo como expansão da matriz extracelular [6], esclerose glomerular intensa e grande infiltração de macrófagos (MØ) (13,14). De maneira semelhante a outras nefropatias, a participação da AII é também descrita nas alterações hemodinâmicas e inflamatórias características do modelo Nx [12,13].…”

Section: Introductionunclassified

Mecanismos de lesão renal progressiva decorrente do tratamento com losartan durante a lactação

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Leonor Ruiz Gurillo and M. Belén Alvarado Ortega: Irony and Humor:From Pragmatics to Discourse

Cited by 4 publications

References 2 publications

Selective activation of angiotensin AT₂ receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis

Selective activation of angiotensin AT₂ receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis

Adiponectin attenuates Ang Ⅱ‐induced TGFβ1 production in human mesangial cells via an AMPK‐dependent pathway

Mecanismos de lesão renal progressiva decorrente do tratamento com losartan durante a lactação

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Leonor Ruiz Gurillo and M. Belén Alvarado Ortega: Irony and Humor:From Pragmatics to Discourse

Cited by 4 publications

References 2 publications

Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis

Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis

Adiponectin attenuates Ang Ⅱ‐induced TGFβ1 production in human mesangial cells via an AMPK‐dependent pathway

Mecanismos de lesão renal progressiva decorrente do tratamento com losartan durante a lactação

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Selective activation of angiotensin AT₂ receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis

Selective activation of angiotensin AT₂ receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis