Leoligin, the Major Lignan from Edelweiss (<i>Leontopodium nivale</i> subsp. <i>alpinum</i>), Promotes Cholesterol Efflux from THP-1 Macrophages

Wang, Limei; Ladurner, Angela; Latkolik, Simone; Schwaiger, Stefan; Linder, Thomas; Hošek, Jan; Palme, Veronika; Schilcher, Nicole; Polanský, Ondřej; Heiss, Elke H.; Stangl, Herbert; Mihovilovic, Marko D.; Stuppner, Hermann; Dirsch, Verena M.; Atanasov, Atanas G.

doi:10.1021/acs.jnatprod.6b00227

Cited by 27 publications

(27 citation statements)

References 31 publications

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“…In addition, the bubble map can also relate to some of the potential biological activities of lignans, e.g., estrogenic and antiestrogenic, antioxidant, anti-inflammatory, and anticancerogenic properties (Baumgartner et al, 2011;Teponno et al, 2016;Wang et al, 2016;Linder et al, 2019;Zálešák et al, 2019), especially with antioxidant and anti-inflammatory activity being identified as frequently mentioned terms, whereas they were strong interests in phytoestrogen and cancer. By limiting to "articles" (excluding other publication types such as reviews), a quick query of "clinical trial*" within the analyzed body of literature returned with 50 hits only.…”

Section: Discussionmentioning

confidence: 99%

“…Within the bioactive compounds realm Santini and Novellino, 2018;Daliu et al, 2019;Durazzo et al, 2019), the class of lignans is of interest for their potential biological activities, i.e., estrogenic and antiestrogenic, antioxidant, antiinflammatory, metabolism-modulating, anti-proliferative, and anticancerogenic properties (Baumgartner et al, 2011;Teponno et al, 2016;Wang et al, 2016;Linder et al, 2019;Zálešák et al, 2019). Moreover, it is worth mentioning that the spectrum of biological activities attributed to lignans is being enlarged, i.e., related to newly discovered compounds belonged to this group (Zhang et al, 2014;Gnabre et al, 2015;Su and Wink, 2015;Hongthong et al, 2016;Azam et al, 2019;Zhuang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Lignans: Quantitative Analysis of the Research Literature

et al. 2020

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The current study provides a comprehensive overview and analysis of the lignan literature. Data for the current study were extracted from the electronic Web of Science Core Collection database via the search string TOPIC = ("lignan*") and processed by the VOSviewer software. The search yielded 10,742 publications. The ratio of original articles to reviews was 14.6:1. Over 80% of the analyzed papers have been published since the year 2000 and nearly 50% since the year 2010. Many of the publications were focused on pharmacology, chemistry, and plant sciences. The United States and Asian countries, such as China, Japan, South Korea, and India, were the most productive producers of lignan publications. Among the 5 most productive institutions was the University of Helsinki in Finland, the country that ranked 9 th . Nineteen journals collectively published 3,607 lignan publications and were considered as core journals. Their impact factor did not correlate with the proportion of uncited papers. Highly cited publications usually mentioned phytoestrogen, isoflavone, daidzein, enterodiol, enterolactone, equol, genistein, and isoflavonoid. Cancer (e.g., breast cancer), cardiovascular disease, and antioxidation were the major themes. Clinical trials were estimated to contribute to 0.2-1.1% of the analyzed body of literature, so more of them should be conducted in the future to substantiate the beneficial effects and optimal dose of lignan intake in humans. Moreover, researchers can refer to these findings for future research directions and collaborations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lignans: Quantitative Analysis of the Research Literature

et al. 2020

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“…Quantification of cholesterol efflux was performed, as described previously . THP‐1 cells (ATCC) were maintained in RPMI‐1640 medium (Lonza) supplemented with 10% fetal bovine serum (Gibco), 100 U/mL penicillin and 100 μg/mL streptomycin, and 2 mmol/L l ‐glutamine (Invitrogen) at 37°C and 5% CO 2 .…”

Section: Methodsmentioning

confidence: 99%

“…Cell viability was assessed by the resazurin conversion assay . For this assay, THP‐1 cells were seeded at 0.4×10 5 cells per well in 96‐well plates and differentiated, then loaded with unlabeled cholesterol and treated with UCB, as described in the previous section.…”

Section: Methodsmentioning

confidence: 99%

Bilirubin Decreases Macrophage Cholesterol Efflux and ATP‐Binding Cassette Transporter A1 Protein Expression

Wang

Tosevska

Heiß

et al. 2017

JAHA

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BackgroundMild but chronically elevated circulating unconjugated bilirubin is associated with reduced total and low‐density lipoprotein cholesterol concentration, which is associated with reduced cardiovascular disease risk. We aimed to investigate whether unconjugated bilirubin influences macrophage cholesterol efflux, as a potential mechanism for the altered circulating lipoprotein concentrations observed in hyperbilirubinemic individuals.Methods and ResultsCholesterol efflux from THP‐1 macrophages was assessed using plasma obtained from normo‐ and hyperbilirubinemic (Gilbert syndrome) humans (n=60 per group) or (heterozygote/homozygote Gunn) rats (n=20 per group) as an acceptor. Hyperbilirubinemic plasma from patients with Gilbert syndrome and Gunn rats induced significantly reduced cholesterol efflux compared with normobilirubinemic plasma. Unconjugated bilirubin (3–17.1 μmol/L) exogenously added to plasma‐ or apolipoprotein A1–supplemented media also decreased macrophage cholesterol efflux in a concentration‐ and time‐dependent manner. We also showed reduced protein expression of the ATP‐binding cassette transporter A1 (ABCA1), a transmembrane cholesterol transporter involved in apolipoprotein A1–mediated cholesterol efflux, in THP‐1 macrophages treated with unconjugated bilirubin and in peripheral blood mononuclear cells obtained from hyperbilirubinemic individuals. Furthermore, we demonstrated that bilirubin accelerates the degradation rate of the ABCA1 protein in THP‐1 macrophages.ConclusionsCholesterol efflux from THP‐1 macrophages is decreased in the presence of plasma obtained from humans and rats with mild hyperbilirubinemia. A direct effect of unconjugated bilirubin on cholesterol efflux was demonstrated and is associated with decreased ABCA1 protein expression. These data improve our knowledge concerning bilirubin's impact on cholesterol transport and represent an important advancement in our understanding of bilirubin's role in cardiovascular disease.

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“…While Leoligin (Fig. 6) proved highly effective against thickening of the inner wall of blood vessels (Reisinger et al, 2009), an unknown terpene shows a significant cancer hostile activity against human leukemia cells (Wang et al 2007). Moreover (Hornick et al, 2008) can showed after taking an extract from the whole root an improvement in the capacity of memory and kick off a discussion for taking this extract in the prevention and treatment of dementia.…”

Section: Fig 4 Aloe Veramentioning

confidence: 99%

VITA Intense – Product with Negative Oxidation-reduction Potential (ORP) as Important Quality for Antioxidant and Inhibition Growth of Tumor Cells Effects. Anti Aging Effects

Ignatov¹,

Pesheva²

2018

European Journal of Medicine

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We studied the mathematical model of interaction with water VITA intense of LavaVitae company (Austria). In this report are submitted data about the interaction of VITA intense with water, obtained by non-equilibrium (NES) and differential-equilibrium energy spectrum (DNES) of water. The average energy (∆EH... O) of hydrogen Н…O-bonds among individual molecules H2O after treatment of VITA intense with water measured by NES-and DNES-methods is ∆E=-0.0136±0.0011 eV for VITA intense. This result suggests the restructuring of ∆EH... O values among H2O molecules with a statistically reliable increase of local extremums in DNES-spectra. The research is performed for VITA intense, with study of pH and oxidative reduction potential (ORP). There is review of the effects of the chemical composition of VITA intense -antiinflammatory, antioxidant etc. With methods NES we show the following effects -relaxing effect of nervous system, anti-inflammatory and inhibition of tumor cells. As results of these effects VITA intense has anti aging influence. The base of this influence is anti-inflammatory effect. This article deals with the review of the basic biophysical-biochemical and biological processes underlying the VITA intense. The author is studying their physical-chemical properties and biophysical and biological effects on human organism. Additionally, by using IR, NES, and DNES methods are investigated various samples of water from Bulgarian water springs: the melt water from Glacier Rosenlaui, Swiss Alps, as well as the human blood serum of people with excellent health and cancer patients between 50 and 70 years old. Other experiments were performed on a 1 % (v/v) solution of VITA intense in deionized water. As an estimation factor in NES and DNES was measured the values of the average energy of hydrogen bonds (∆EH...O) among H2O molecules in water samples, as well as a local extremums in the NES and DNES-spectra of various samples of water and the human blood serum at E = -0.1387 eV and λ = 8.95 μm. For a group of people in critical condition of life and patients with malignant tumors the greatest values of local extremums in IR-, DNESspectra were shifted to lower energies relative to the control healthy group. Further we applied this method for calculation of percent distribution of H2O molecules in all studied water samples according to energies of hydrogen bonds ranged from (-0.08 to -0.1387 eV). It was shown that mountain water is among the most important factors for human longevity and human health. The variety of ions (K + , Na + , Ca 2+ , Mg 2+ , Mn 2+ , Fe 2+ , Fe 3+ , Zn 2+ , SO4 2-, Cl -, HCO3 -, CO3 2-), the chemical-physical parameters (pH, electroconductivity) and the decreased content of deuterium in studied water samples renders beneficial effects of these types of water on human health. We are applying the conclusions for the effects of mountain water on human health and longevity as base * Corresponding author E-mail addresses: mbioph@abv.bg (I. Ignatov) European Journal of Medicine, 2018, 6(1) ...

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Leoligin, the Major Lignan from Edelweiss (Leontopodium nivale subsp. alpinum), Promotes Cholesterol Efflux from THP-1 Macrophages

Cited by 27 publications

References 31 publications

Lignans: Quantitative Analysis of the Research Literature

Lignans: Quantitative Analysis of the Research Literature

Bilirubin Decreases Macrophage Cholesterol Efflux and ATP‐Binding Cassette Transporter A1 Protein Expression

VITA Intense – Product with Negative Oxidation-reduction Potential (ORP) as Important Quality for Antioxidant and Inhibition Growth of Tumor Cells Effects. Anti Aging Effects

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