Lenvatinib Can Overcome Immune Resistance in Head and Neck Cancer and Achieve Durable Remission

Abstract

Squamous cell carcinoma head and neck is the sixth most common cancer worldwide and. 1 Multimodality therapies have been advocated for locoregional relapse or metastatic disease. 2 Combination therapy with lenvatinib has been considered to overcome resistance and improve the efficacy. 3 In a recent study of lenvatinib and pembrolizumab conducted in heavily pretreated recurrent and metastatic head and neck cancer, the median overall survival OS was 6.2 months, and the median progression-free survival (PFS) was 4.6 months. 4