Abstract:To the Editor:Antiangiogenic receptor tyrosine kinase inhibitors (TKIs) target proangiogenic molecules in tumor microenvironment and induce apoptosis by inhibiting angiogenesis and further tumor proliferation. These are used in the treatment of multiple cancers due to remarkable clinical efficacy. 1 Lenvatinib is a multikinase inhibitor targeting vascular endothelial growth factor receptors 1, 2, and 3; fibroblast growth factor receptors 1-4; plateletderived growth factor a; receptor tyrosine kinase; and rearr… Show more
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