Lentinan PLGA-stabilized pickering emulsion for the enhanced vaccination

Jiao, Lina; Liu, Zhenguang; Zhang, Yue; Feng, Zian; Gu, Peng; Huang, Yee; Liu, Jiaguo; Wu, Yi; Wang, Deyun

doi:10.1016/j.ijpharm.2021.121348

Cited by 16 publications

(7 citation statements)

References 45 publications

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“…Although medical technology advances and diversifies in treatment methods, cancer prevention is still very important, and the development and application of cancer vaccines are of great significance in reducing the global cancer burden. Studies have shown that LNT has great potential for vaccine delivery, acting as a vaccine adjuvant, enhancing vaccine immunity and mitigating vaccine response [91][92][93].…”

Section: Discussionmentioning

confidence: 99%

Lentinan progress in inflammatory diseases and tumor diseases

Zhou,

Liu,

Yuan

et al. 2024

Eur J Med Res

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Shiitake mushrooms are a fungal food that has been recorded in Chinese medicine to nourish the blood and qi. Lentinan (lLNT) is an active substance extracted from shiitake mushrooms with powerful antioxidant, anti-inflammatory, anti-tumor functions. Inflammatory diseases and cancers are the leading causes of death worldwide, posing a serious threat to human life and health and posing enormous challenges to global health systems. There is still a lack of effective treatments for inflammatory diseases and cancer. LNT has been approved as an adjunct to chemotherapy in China and Japan. Studies have shown that LNT plays an important role in the treatment of inflammatory diseases as well as oncological diseases. Moreover, clinical experiments have confirmed that LNT combined with chemotherapy drugs has a significant effect in improving the prognosis of patients, enhancing their immune function and reducing the side effects of chemotherapy in lung cancer, colorectal cancer and gastric cancer. However, the relevant mechanism of action of the LNT signaling pathway in inflammatory diseases and cancer. Therefore, this article reviews the mechanism and clinical research of LNT in inflammatory diseases and tumor diseases in recent years.

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Section: Discussionmentioning

confidence: 99%

Lentinan progress in inflammatory diseases and tumor diseases

Zhou,

Liu,

Yuan

et al. 2024

Eur J Med Res

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“…Up to now, there have only been a few studies on the injection administration of Pickering emulsions. These injectable Pickering emulsions have been primarily investigated for subcutaneous delivery of vaccines and immune adjuvants [ 48 , 49 , 50 ] utilizing PLGA-based nanoparticles, such as Chinese yam polysaccharide PLGA nanoparticles and Lentinan PLGA nanoparticles as solid particle stabilizers. An intra-articular DNSPE was reported recently.…”

Section: Current Application Of Dnspes In Drug Deliverymentioning

confidence: 99%

Progress of Drug Nanocrystal Self-Stabilized Pickering Emulsions: Construction, Characteristics In Vitro, and Fate In Vivo

Zhang,

Dong,

Liu

et al. 2024

Pharmaceutics

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A drug nanocrystal self-stabilized Pickering emulsion (DNSPE) is a novel Pickering emulsion with drug nanocrystals as the stabilizer. As a promising drug delivery system, DNSPEs have attracted increasing attention in recent years due to their high drug loading capacity and ability to reduce potential safety hazards posed by surfactants or specific solid particles. This paper comprehensively reviews the progress of research on DNSPEs, with an emphasis on the main factors influencing their construction, characteristics and measurement methods in vitro, and fate in vivo, and puts forward issues that need to be studied further. The review contributes to the advancement of DNSPE research and the promotion of their application in the field of drug delivery.

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“…Lentinan (LNT), the ⊎-1, 3-D glucan with ⊎-1, 6-D-glucopyranoside branches was obtained and purified from a popular edible mushroom (Lentinus edodes) with antibacterial and immunomodulatory effects. 11 Studies have shown that shiitake polysaccharides can inhibit LPS-induced activation of the Wnt/⊎-catenin pathway (mammary epithelium cells of mice) to exert anti-mastitis effects. 12 It has also been reported to protect cardiomyocytes from hypoxia-induced injury by regulating microRNA-22/Sirt1.…”

Section: Introductionmentioning

confidence: 99%

Effect of lentinan on gelling properties and structural changes of goose myofibrillar protein under oxidative stress

Fan

Liu

et al. 2023

J Sci Food Agric

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BACKGROUND The reduction of protein oxidation is important for maintaining the product quality of reconstituted meat. In this study, the dose‐dependent effects of lentinan (LNT) on gelling properties and chemical changes in oxidatively stressed goose myofibrillar protein were investigated. RESULTS Myofibrillar protein (MP) with 200 μmol g−1 protein LNT increased gel strength by 87.90 ± 9.26% in comparison with LNT‐free myofibrillar protein after oxidation. Scanning electron microscopy analysis revealed that the gel network containing LNT was compact, with small pores and uniform distribution. The absolute value of the zeta potential reduced significantly following oxidation of LNT with 200 μmol g−1 protein at 4 °C for 12 h compared with the zeta potential without LNT, according to the laser particle size analyzer. The incorporation of LNT increased protein solubility and –SH content, inhibited carbonyl formation, enhanced α‐helix content and tryptophan intrinsic fluorescence intensity, and reduced exposure of hydrophobic groups and protein aggregation. CONCLUSION The results indicated that adding LNT to myofibrillar protein could improve gel. This is related to its protective effect on conformational changes in the oxidation system. Lentinan is therefore recommended for oxidatively stressed goose meat processing to enhance the MP gelling potential. © 2023 Society of Chemical Industry.

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Lentinan PLGA-stabilized pickering emulsion for the enhanced vaccination

Cited by 16 publications

References 45 publications

Lentinan progress in inflammatory diseases and tumor diseases

Lentinan progress in inflammatory diseases and tumor diseases

Progress of Drug Nanocrystal Self-Stabilized Pickering Emulsions: Construction, Characteristics In Vitro, and Fate In Vivo

Effect of lentinan on gelling properties and structural changes of goose myofibrillar protein under oxidative stress

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