Lentinan, a distinct T cell oriented immunopotentiator; its immunopharmacological action

Hamuro, J.; Chihara, Goro

doi:10.1016/0192-0561(82)90127-8

Cited by 3 publications

(2 citation statements)

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“…7,26 Lentinan is a high-molecular-weight polysaccharide and a biological response modifier that can activate the immune system. 27,28 Lentinan has been extensively studied because of its few side effects and bioavailability. Since 1985, lentinan has been clinically used in the treatment of cancer and combined with chemotherapy.…”

Section: ■ Introductionmentioning

confidence: 99%

“…As an immunological adjuvant, herbal polysaccharides can stimulate lymphocyte proliferation activity and enhance antibody titers . In recent years, the polysaccharide research field has focused on structural improvement and molecular modification, and polysaccharide complexes have shown stronger biological activities. , Lentinan is a high-molecular-weight polysaccharide and a biological response modifier that can activate the immune system. , Lentinan has been extensively studied because of its few side effects and bioavailability. Since 1985, lentinan has been clinically used in the treatment of cancer and combined with chemotherapy …”

Section: Introductionmentioning

confidence: 99%

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Lentinan-Modified Carbon Nanotubes as an Antigen Delivery System Modulate Immune Response in Vitro and in Vivo

Xing

Liu

Huang

et al. 2016

ACS Appl. Mater. Interfaces

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Adjuvants enhance immunogenicity and sustain long-term immune responses. As vital components of vaccines, efficient adjuvants are highly desirable. Recent evidence regarding the potential of carbon nanotubes (CNTs) to act as a support material has suggested that certain properties, such as their unique hollow structure, high specific surface area, and chemical stability, make CNTs desirable for a variety of antigen-delivery applications. Lentinan, a β-1,3-glucohexaose with β-1,6-branches that is extracted from the mushroom Lentinus edodes, is an effective immunostimulatory drug that has been clinically used in Japan and China, and recent studies have proved that specific beta-glucans can bind to various immune receptors. In this research, we covalently attached lentinan to multiwalled carbon nanotubes (MWCNTs) and tested their ability to enhance immune responses as a vaccine delivery system. In vitro study results showed that the nanotube constructs could rapidly enter dendritic cells and carry large amounts of antigen. Moreover, maturation markers were significantly upregulated versus the control. Thus, lentinan-modified multiwalled carbon nanotubes (L-MWCNTs) were regarded as an effective intracellular antigen depot and a catalyzer that could induce phenotypic and functional maturation of dendritic cells. Furthermore, compared with L-MWCNTs (35 μg/mL), a corresponding concentration of carboxylic carbon nanotubes (C-MWCNTs, 31.8 μg/mL) and an equivalent concentration of lentinan (3.2 μg/mL) did not remarkably influence the immune reaction in vitro or in vivo. Hence, we can hypothesize that the capability of L-MWCNTs was a consequence of the increased intracellular quantity of lentinan grafted onto the nanotubes. Overall, our studies demonstrated that L-MWCNTs significantly increased antigen accumulation in the cells and potentiated cellular and humoral immunity. In conclusion, L-MWCNTs constitute a potential vaccine delivery system to enhance immunogenicity for therapeutic purposes.

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Section: ■ Introductionmentioning

confidence: 99%