Lentigo maligno

Samaniego, E.; Redondo, Pedro

doi:10.1016/j.ad.2012.05.006

Cited by 22 publications

(15 citation statements)

References 126 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accordance with the literature we confirm that LM and LMM are located predominantly on the head and neck, indicating the ultraviolet‐related background of this skin tumour . In LM and LMM, the transition at the peripheral margin of the lesion from neoplastic to non‐neoplastic melanocytes can be very poorly defined, in particular in severely sun‐damaged skin .…”

Section: Clinicopathological Findings In 270 Patients With Lentigo Masupporting

confidence: 89%

“…The recurrence rates observed in the present study were not associated with higher Clark levels or increased tumour thickness. Micrographically controlled surgery, including a full examination of all excised peripheral margins, results in excellent recurrence‐free rates . Our 5‐ and 10‐year local recurrence‐free survival data confirm the great value of micrographically controlled surgery using relatively small excisions margins in LM and LMM diagnosis .…”

Section: Clinicopathological Findings In 270 Patients With Lentigo Masupporting

confidence: 71%

See 1 more Smart Citation

Clinicopathological characteristics of 270 patients with lentigo maligna and lentigo maligna melanoma: data from a German skin cancer centre

et al. 2014

View full text Add to dashboard Cite

DEAR EDITOR, Recurrence rates following conventional surgery for lentigo maligna (LM)a form of in situ melanomaand lentigo maligna melanoma (LMM)the invasive form of LM have previously been reported as between 7% and 15%. 1,2 We aim to present our single-centre experience with LM and LMM, focusing on clinical and pathological characteristics including recurrence and survival analysis.This monocentric study was performed at the Skin Cancer Center Ruhr-University (Bochum, North Rhine-Westphalia, Germany). The study was approved by the ethics review board of the Ruhr-University Bochum. We assessed the records of patients with LM and LMM from 2000 to 2012. Clinicopathological parameters such as age, sex, anatomical site of primary, melanoma subtype, Clark level, tumour regression, ulceration and thickness (Breslow) were analysed. Follow-up data were collected using chart review and by contacting resident practitioners and dermatologists. LM and LMM were entirely removed with a small excision margin and then assessed by micrographically controlled histology. All tumours were stained with haematoxylin and eosin. Immunohistochemistry included staining with S100 and Melan-A/MART-1 (melanoma-associated antigen recognized by T cells). All melanomas had been assessed by two senior dermatohistopathologists.Patients with LMM of tumour thickness ≥ 1 mm and/or ulcerated LMM (> 0Á75 mm) underwent sentinel lymph node biopsy. Patients with positive sentinel lymph nodes were treated with complete lymph node dissection and high-dose interferon-a2b. Data analysis was performed using the statistical package MedCalc Software (MedCalc, Mariakerke, Belgium). Non-normally distributed data were expressed as median and range. Data were analysed using the v 2 -test. Local recurrencefree survival and overall survival were examined using the Kaplan-Meier method and Cox regression analysis. Survival curves were calculated from the time of diagnosis of the primary melanoma, and were considered censored for patients alive at the last follow-up, or in the event of nonmelanomarelated deaths or unavailable data. P-values < 0Á05 were considered significant.Data were available for 270 patients [122 (45Á2%) female; 148 (54Á8%) male]; median age 80 years (range 47-102); with LM (124/270, 45Á9%) or LMM (146/270, 54Á1%). The median LMM tumour thickness was 0Á35 mm (range 0Á1-6Á9), and Clark level was II in 88 patients, III in 30, IV in 27 and V in one patient. Overall 133 of 146 patients (91%) had LMM with tumour thickness < 1 mm. Ulceration was observed in five patients (1Á9%), and regression was not observed (Table 1). In total 241 of 270 tumours (89Á3%) AJCC, American Joint Committee on Cancer. a Mean follow-up 64Á4 months (range 5-151).

show abstract

Section: Clinicopathological Findings In 270 Patients With Lentigo Masupporting

confidence: 89%

Section: Clinicopathological Findings In 270 Patients With Lentigo Masupporting

confidence: 71%

Clinicopathological characteristics of 270 patients with lentigo maligna and lentigo maligna melanoma: data from a German skin cancer centre

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Ill-defined margins and subclinical extension are common with lentigo maligna and, as in this case, lead to involved excision margins. 3,4 It can be difficult to differentiate the histopathological appearance of atypical melanocytic hyperplasia seen in sun-damaged skin from lentigo maligna. 5 Sun-damaged skin can show features in common with lentigo maligna.…”

Section: Answermentioning

confidence: 99%

“…5 A crucial principle is to avoid wound closures that distort the margin until no further excisions are needed. 3,6 Complex flaps will distort margins and make re-excision problematic. Reconstruction can be delayed until histopathology confirms adequate clearance.…”

Section: Answermentioning

confidence: 99%

Dealing with lentigo maligna: A challenging case

Mazzoni

2021

Aust J Gen Pract

View full text Add to dashboard Cite

“…In the realm of early pigmented flat lesions commonly observed on chronically sun‐damaged facial skin, PAK and LPLK represent the greatest challenge in their dermoscopic differentiation from LM as they show similar dermoscopic features, making their differential diagnosis difficult . In the attempt to improve the diagnostic accuracy, algorithms (as well as multivariate diagnostic models based on the most specific clues of each flat pigmented facial lesion) have recently been elaborated .…”

Section: Introductionmentioning

confidence: 99%