Lentigo maligna in a patient with xeroderma pigmentosum, variant type: A case report with dermoscopic findings and review of the literature

Bang, Eunsik; Kim, Ye Eun; Ko, Jung Min; Kim, Man Jin; Park, Sung Sup; Seong, Moon Woo; Mun, Je Ho

doi:10.1111/phpp.12568

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…80 Dermoscopy is a useful non-invasive diagnostic tool to discriminate between benign and malignant lesions in XP. 81,82 The presence of an asymmetrical blotch or irregular globules and dots are common dermoscopic features of malignant lesions. 82 Malignant melanoma can be differentiated from benign melanocytic nevi by the presence of variegated colours, asymmetry, prominent pigment network, blue-grey areas, blotches, atypical dots/globules, perifollicular pigmentation and follicular obliteration.…”

Section: Diagnosismentioning

confidence: 99%

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Xeroderma pigmentosum: an updated review

Leung¹,

Barankin²,

Lam³

et al. 2022

DIC

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Background: Early recognition of xeroderma pigmentosum is important to minimize the complications arising from the harmful effects of exposure to ultraviolet radiation. This narrative review aims to familiarize physicians with the clinical features, diagnosis and management of xeroderma pigmentosum. Methods:A search was conducted in December 2021 in PubMed Clinical Queries using the key term "xeroderma pigmentosum". The search strategy included all clinical trials, observational studies and reviews published within the past 10 years. The information retrieved from the search was used in the compilation of this article.Results: Xeroderma pigmentosum is a condition of abnormal DNA repair of ultraviolet radiation-induced and oxidative DNA damage, which leads to increased skin cancer susceptibility. Approximately 50% of patients with xeroderma pigmentosum have increased photosensitivity and certain types of xeroderma pigmentosum are more prone to ocular disease and progressive neurodegeneration depending on the causative mutation. The diagnosis should be suspected in patients with increased photosensitivity and characteristic cutaneous, ophthalmological and neurological findings. A definite diagnosis can be made by the identification of biallelic mutation in one of the causative genes. Strict and consistent sun avoidance and protection and early detection and treatment of premalignant and malignant skin lesions are the mainstays of management. Treatment options for actinic keratosis include cryotherapy, topical imiquimod, topical 5-fluorouracil, chemical peeling, excision, CO 2 laser resurfacing, fractional/pulsed laser therapy, and photodynamic therapy. Cutaneous malignancy can be treated by photodynamic therapy, curettage and electrodesiccation, or surgical excision. Oral isotretinoin, oral niacinamide, topical imiquimod and topical fluorouracil can be used for the prevention of skin malignancy. Treatment options for poikiloderma include chemical peeling, dermabrasion and laser resurfacing. Methylcellulose eyedrops and soft ultraviolet-protective contact lenses may be used to keep the cornea moist and protect against the harmful effects of keratitis sicca. Investigational therapies include the use of T4 endonuclease-V liposome lotion and oral nicotinamide to reduce the rate of actinic keratoses and non-melanoma skin cancers and gene therapy for radical cure of this condition. Conclusion:Although currently there is no cure for xeroderma pigmentosum, increased awareness and early diagnosis of the condition, followed by rigorous sun avoidance and protection and optimal management, can dramatically improve the quality of life and life expectancy.

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Section: Diagnosismentioning

confidence: 99%

“…82 Malignant melanoma can be differentiated from benign melanocytic nevi by the presence of variegated colours, asymmetry, prominent pigment network, blue-grey areas, blotches, atypical dots/globules, perifollicular pigmentation and follicular obliteration. 81,82…”

Section: Diagnosismentioning

confidence: 99%

Xeroderma pigmentosum: an updated review

Leung¹,

Barankin²,

Lam³

et al. 2022

DIC

View full text Add to dashboard Cite

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A facial lentiginous nevus with atypical clinical features in a child: The importance of in vivo reflectance confocal microscopic findings

Duman,

Yaman,

Oraloğlu

et al. 2024

Pediatric Dermatology

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A 14‐year‐old girl presented with a facial‐pigmented lesion suspicious of melanoma clinically and dermoscopically. In vivo, reflectance confocal microscopy (RCM) findings excluded melanoma by revealing typical epidermal honeycomb and cobblestone patterns. Well‐defined follicular contours were seen at the dermal–epidermal junction; there were no elongated, “medusa head‐like” follicular protrusions or folliculotropism, which are classical findings seen in lentigo maligna. With this report, we aim to demonstrate the significance of utilizing RCM technology in difficult to diagnose lentiginous pigmented lesions.

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Lentigo maligna in a patient with xeroderma pigmentosum, variant type: A case report with dermoscopic findings and review of the literature

Cited by 2 publications

References 11 publications

Xeroderma pigmentosum: an updated review

Xeroderma pigmentosum: an updated review

A facial lentiginous nevus with atypical clinical features in a child: The importance of in vivo reflectance confocal microscopic findings

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