Lenticulostriate Artery Involvement is Predictive of Poor Outcomes in Superficial Middle Cerebral Artery Territory Infarction

Lee, Kijeong; Kim, Eun Hye; Song, Dongbeom; Nam, Hyo Suk; Lee, Hye Sun; Heo, Ji Hoe

doi:10.3349/ymj.2017.58.1.123

Cited by 7 publications

(8 citation statements)

References 32 publications

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“…the leptomeningeal branches, of the parent artery, occlusion of a latter branch may lead to occurrence of both a superficial and a deep ischemic lesion. The association of those two types of infarcts was described by some other authors as well, although most often as a consequence of the global cerebral or systemic atherosclerosis [37].…”

Section: Discussionmentioning

confidence: 66%

“…The pathologic changes were noticed in patients with a visible atherosclerosis of the large arteries at the base of the brain, but in none within the control group. Similarly, some authors found a correlation between general atherosclerosis and the appearance of cerebral infarcts [37,39]. This may have three explanations.…”

Section: Discussionmentioning

confidence: 84%

“…It is obvious that this lesion is a result of thromboembolism, or a partial occlusion of the M1 segment of the middle cerebral artery [5,9,11]. In such patients, the morbidity and the mortality rate is higher than in those with an isolated ischemic lesion, either a deep or a superficial one [37].…”

Section: Discussionmentioning

confidence: 99%

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Clinical Significance of the Cerebral Perforating Arteries

Antunović

Mirčić

Marinković

et al. 2017

Prilozi

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There is scarce data in the contemporary literature regarding the correlation of the microanatomy of the perforating arteries, their atherosclerosis, and the ischemia in their territory. In order to examine, at least partially, those parameters, the perforating arteries of 12 brains were microdissected or their vascular casts were obtained. In addition, 30 specimens of the perforators were used for a histological and immunohistochemical study. Finally, radiological images of 14 patients with deep cerebral infarcts were examined following a selection among 62 subjects. It was found out that certain groups of the perforators ranged in number between 0 to 11 (1.1-8.4 on average). In addition to the origin from the parent vessels, some of the perforators also arose from the leptomeningeal branches. Occlusion of such a branch may result in both a superficial and a deep ischemic lesion. Besides, the common stems of certain perforators supplied both right and left portions of the corresponding brain regions. Occlusion of such a common trunk leads to bilateral infarction. The atherosclerosis of the perforating vessels, which was found in one third of the specimens, is the basis for the ischemic lesions development on their territory. Among the 62 patients with ischemic lesions, 14 had a deep cerebral infarcts, most often within the thalamus, as well as on the territory of the middle cerebral and the anterior choroidal artery perforators of the hemispheres. Our study showed that a strong correlation exists between certain microanatomical features, atherosclerosis, and region of supply of the perforating arteries, on the one hand, and location of the ischemic lesions on the other hand.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 84%

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Clinical Significance of the Cerebral Perforating Arteries

Antunović

Mirčić

Marinković

et al. 2017

Prilozi

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“…In a MRA, the internal carotid artery and vertebral artery system are often normal. MR fiber tracking was helpful, which demonstrated that the severity of motor deficit depends on the extent of the infarct in the upper part of the internal capsule (45,46).…”

Section: Radiological Featuresmentioning

confidence: 99%

Current status of infarction in the basal ganglia‑internal capsule due to mild head injury in children using PRISMA guidelines (Review)

Wang

Luan

et al. 2019

Exp Ther Med

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Post-traumatic basal ganglia-internal capsule (BGIC) infarction in pediatric patients is a relatively rare consequence of mild head injury (MHI). To the best of the authors' knowledge, at present, no comprehensive review has been published. To review research on BGIC infarction after MHI, a literature search was performed using the PubMed database and relevant search terms. According to recent data, MHI may cause BGIC infarction due to mechanical vasospasm of the perforating vessels in pediatric patients. The anatomical characteristics of the growing brain in infancy, mineralization of the lenticulostriate arteries and viral infection may all play a part in BGIC infarction after MHI, which often occurs within 24 months. Symptoms are not as severe and tend to disappear in the early period. Computed tomography or magnetic resonance imaging often shows BGIC infarction. There are also children with scattered calcification of the basal ganglia. Neural rehabilitation is a commonly accepted treatment. The prognosis of patients with BGIC infarction after MHI consistently improves.

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“…Stroke is a major contributing factor for brain ischemia and the third leading cause of mortality in Western countries. Brain ischemia leads to movement, visual, sensory, and behavioral disorders, especially aphasia and impaired spatial learning [2–4].…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Doses and Times of FK506 on Different Areas of the Hippocampus in the Rat Model of Transient Global Cerebral Ischemia-Reperfusion

Sharifi

Arani

Olya

et al. 2019

Neurology Research International

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Background. Stroke is a major worldwide problem that is leading to a high mortality rate in humans. Ischemia, as the most common type of stroke, is characterized by tissue damage that can occur due to insufficient blood flow to the brain even for a brief duration, leading to the release of inflammatory factors, cytokines, and free radicals. In this study, we investigated the effective dose and injection time of FK506 as an immunophilin ligand for providing a suitable effect on cells of CA2, CA3, and dentate gyrus of the hippocampus. Methods. In this in vivo study, a total of 48 male Wistar rats were divided into nine groups. The ischemia model was induced by the ligation of bilateral common carotid arteries. The doses of FK506 (3, 6, and 10 mg/kg) were administered intravenously (IV) at the beginning of reperfusion, followed by repeated injections (10 mg/kg) at 6, 24, 48, and 72 hours after ischemia, respectively. Brains were removed and prepared for Nissl staining and the TdT-mediated dUTP Nick End Labeling method. Results. Data showed that global ischemia did not decrease the number of viable pyramidal cells in CA2 and CA3 regions, but significant differences were observed in the number of viable granular cells and apoptotic bodies in the dentate gyrus between the control and ischemia groups. Repeated doses of 6 mg/kg of FK506 at an interval of 48 hours were deemed to be the suitable dose and best time of injection. Conclusions. It seems that FK506 can ameliorate the extent of apoptosis and may be a good candidate for the treatment of ischemia-induced brain damage.

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Lenticulostriate Artery Involvement is Predictive of Poor Outcomes in Superficial Middle Cerebral Artery Territory Infarction

Cited by 7 publications

References 32 publications

Clinical Significance of the Cerebral Perforating Arteries

Clinical Significance of the Cerebral Perforating Arteries

Current status of infarction in the basal ganglia‑internal capsule due to mild head injury in children using PRISMA guidelines (Review)

Effect of Different Doses and Times of FK506 on Different Areas of the Hippocampus in the Rat Model of Transient Global Cerebral Ischemia-Reperfusion

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